Abstract

         Background and Objective: According to Iranian, Asian, Indian, and Chinese traditional medicine, basil is used in the treatment of different diseases. In this study, the effect of basil on lowering the blood glucose was examined in healthy and diabetic rats.

        Methods: Sixty Wistar rats were divided into a control group(n=10), a basil receiving group (n=20) and a diabetic group (n=30)(60 mg/kg Streptozotocin- Intraperitoneal injection) and the rats in each group received basil orally in pairs. Forty-eight hours after injection of streptozotocin, 2 and 4 mg/kg doses of basil were prescribed orally for the diabetic group daily for 45 days. in end of study for record serum testosterone ,5 cc blood was sampled from each rat.

       Results: There was a significant correlation between the oral administration of 2 and 4 mg/kg doses of basil and reduced blood glucose level and testosterone changes in the diabetic groups (P<0.05). Twenty-four hours after the first administration, basil caused a significant decrease in the blood glucose level and this  effects continued for 24, 48, and 72 hours, respectively. In contrast, basil had no hypoglycemic effect in the healthy rats.

         Conclusion: The results indicated that 2 and 4 mg/kg doses of basil had significant hypoglycemic effects on the diabetic groups and compensated for the testosterone level in diabetic rats, but had no effect on the healthy rats.

        Keywords: Streptozotocin, Testosterone, Ocimum basiilicum, Diabetes Mellitus.

Abstract

      Background and Objectives: Diabetes induced oxidative stress plays an important role in pathological damage to the heart and liver by increased production of extracellular matrix. It is thought that the use of medicinal plants, particularly Portulaca oleracea. L and regular exercise are effective. The aim of this study was to evaluate the effects of Portulaca oleracea. L consumption along with resistance training on cathepsin S, cystatin C and C-reactive protein (CRP) levels on type 2 diabetes patients.

     Methods: In this semi-experimental study, 28 female type 2 diabetes patients with a mean age of 52 were randomly devided into 4 groups of control, exercise, supplement and supplement-exercise. Portulaca oleracea. L supplement was cosumed 7.5 g per day. Resistance training program was performed with a rubber band for 8 weeks, 3 days a week for 60 minutes with40-50% intensity, up to a maximum repetition. Blood samples were taken before and 48 hours after the last intervention.

     Results: After eight weeks, cathepsin S, cystatin C and CRP levels in the supplementation and supplementaion-exercise group were significantly reduced (P<0.05). There were also significant differences between the groups.

    Conclusion: Portulaca oleracea. L consumption and resistance training have each separate positive impacts on the cathepsin S, cystatin C and CRP levels, but the simultanous effect of Portulaca oleracea. L seed consumption and physical activity can lead to a better efficiency.

     Keywords: Portulaca oleracea, resistance training, cathepsin S,  cystatin C, C-reactive protein, type 2 diabetes mellitus.