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Background and Objective: Osteoarthritis (OA) and cardiovascular disease (CVD) are highly prevalent. The purpose of the present study was to investigate the effect of regular aerobic training and hyaluronic acid on cardiac tissue Wnt signaling pathway in experimental model of knee OA.
Methods: 42 male rats were divided into 6 groups (7 in each group): 1) control, 2) patient, 3) salin, 4) HA, 5) exercise, and 6) exercise + HA. In the training groups, the OA model was first induced, followed by 5 days of running on the treadmill for 5 weeks. Hyaluronic acid was injected intra-articularly. After 12 to 14 hours of fasting and 72 hours after the last training session, cardiac tissue sampling was performed for β-catenin and glycogen synthase kinase-3 (GSK-3β) analysis. The expression of the β-catenin and GSK-3β genes in the cardiac tissue was analyzed by RT-PCR. Data analysis was performed using one-way ANOVA if  a significant difference was observed by Tukey's post hoc test (P <0.05).
Results: Induction of OA in rats led to a significant increase in β-catenin gene  and a significant decrease in cardiac tissue GSK3 gene compared to healthy control group. The results also showed that regular aerobic training, hyaluronic acid injection, and a combination of both treatments reduced the cateninβ gene and  increased the cardiac tissue GSK3 gene compared to the rats of OA group.
Conclusion: Regular aerobic training in combination with hyaluronic acid may exert its protective effect by reducing the expression of β-catenin and increasing the expression of cardiac tissue GSK-3β gene ; this may be  caused by the heart disease in the model, empirically preventing osteoarthritis.

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Background: Significant economic consequences can lead to various problems and complications, including medical complications. Coronary artery disease (CAD), a serious health threat with increasing prevalence, is a major cause of death and mortality worldwide. This study aimed to investigate the effects of a special training program on cytochrome P450 (CYP) gene expression and reactive oxygen species (ROS) levels in patients with coronary artery bypass surgery.
Methods: This semi-experimental study was conducted on 16 patients who underwent coronary artery surgery in Babol City, Iran. The patients were selected using a random sampling method and divided into 2 groups: experimental and control groups. The experimental group engaged in an exercise program consisting of 3 sessions per week for a duration of 8 weeks. The expression levels of CYP and ROS genes were measured by the real-time polymerase chain reaction (PCR) method. The analysis was performed by comparing covariances and means.
Results: ROS gene expression levels significantly decreased in the experimental group than in the control group (P=0.003). However, there was no significant difference in P450 levels between the experimental and control groups (P=0.99).
Conclusion: Special exercises reduced ROS expression and increased P450 expression in patients who had coronary bypass surgery. There is a probability that special exercises, can effectively prevent heart damage by increasing antioxidant capacity and reducing ROS.