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The Role of Increased Uric Acid in Predicting Pre-eclampsia at The Gestational Age of 24-28 Weeks
Sh Aram, A Khalilian,
Volume 1, Issue 1 (Spring - Summer 2007 [PERSIAN] 2007)
Abstract

Abstract Background and objectives: Despite prenatal care, pre-eclampsia is still one of the most important causes of maternal and fetal mortality. There is no screening test for pre-eclampsia to be reliable and economical. One of the most accessible and easiest screening tests is blood uric acid measurement. The goal of this study is to assess the level of uric acid in high risk pregnant women a few weeks before emerging the manifestations of pre- eclampsia. Materials& Methods: In this study carried out in Isfahan medical centers, 124 pregnant women with gestational age of 24-28 weeks were selected by simple non-probability sampling. Then the subjects' uric acid were measured and considered high if it would be more than 4.5mg/dl. Results: of all the subjects, only 20 (16.1%) suffered from preeclampsia. 10 of 39(31.4%) who had high uric acid(more than 4.5mg/dl) showed pre-eclampsia.It is true for low uric acid women(68.6%), that is , the number of pre-eclampsia was ten. Conclusion: Relative risk of increased level of uric acid in preeclampsia at 24-28 weeks of gestational age was 2.2. Chi-square test showed that there is significant difference between the level of uric acid at 24-28 weeks of gestational age and the Incidence of preeclampsia. Keywords: pre-eclampsia, uric acid- high risk pregnancy


Antibiotic Resistance Patterns and Prevalence of PER and VEB Resistance Genes among Clinical Isolates of ESBL-Producing Acinetobacter Baumannii
Hasan Vahidi Emami , Mohaddeseh Khalilian, Narges Yadollahi Movahhed ,
Volume 12, Issue 1 (Jan-Feb 2018)
Abstract
ABSTRACT
         Background and Objectives: Acinetobacter species are responsible for a wide range of clinical complications in hospitalized patients. Antimicrobial treatment of clinical strains of Acinetobacter baumannii may be compromised due to multiple-drug resistance to b-lactams. Aim of this study was to determine antibiotic resistance patterns and frequency of PER and VEB genes in A. baumannii isolates from hospitalized patients.
          Methods: In this cross-sectional study, 100 clinical strains of A. baumannii were isolated from patients hospitalized in Qom (Iran) using specific culture media and biochemical tests. The disk diffusion method was performed to determine resistance to some antibiotics. Minimum inhibitory concentration (MIC) for cefepime and ceftazidime was evaluated. Identification of ESBL-producing strains and presence of the PER and VEB genes were determined by combined disk test and polymerase chain reaction, respectively.
         Results: The isolates were highly resistant against cefixime, ceftriaxone and cefepime. Lowest level of resistance was against polymyxin B. In addition, 70% of the isolates were multi-drug resistant. MIC<128 µg/ml to ceftazidime and cefepime was observed in 84% and 91% of the strains, respectively. Moreover, 21% of the strains were ESBL-positive and frequency of the PER and VEB genes was 47% and 32%, respectively.
        Conclusion: Majority of A. baumannii isolates are highly resistant to the tested antibiotics. Due to presence of the PER and VEB genes in the isolated strains, there is the possibility of resistance spread to other bacteria. Therefore, it is recommended to modify the consumption pattern for antibiotics and pay more attention to standards of nosocomial infection control.
         Keywords: Acinetobacter baumannii, Drug resistance, PER, VEB.

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