M Shadman, S Abedian Kenari, A Alizadeh, M Kaveh, V Hosseini,
Volume 7, Issue 3 (Autumn 2013)
Abstract
Abstract
Background and Objective: Celiac is an autoimmune disease that is characterized by an immune-system-related damage in the intestinal tissue after consumption of gluten. There is not any general agreement for gold standard. The Purpose of this study was the evaluation of specificity and sensitivity of anti-endomysial (EMA) and anti-tissue transglutaminase (TTG) serological test compared to small-bowel biopsy.
Material and Methods: In the cross sectional study, we took blood specimen from 1825 patients with gastrointestinal disease. All the samples were tested by TTG and EMA kits using ELISA. The patients were studied in two groups. First, the individuals whom their serologic test was positive but their tissue condition was normal and second, those with positive serologic test with pathologic tissue results that show they have celiac disorder.
Results: The mean of EMA and TTG shows that the level of antibodies in group 2 is significantly higher than that of the first group (P ≤0.001). There is positive correlation between modified marsh criteria of small-bowel biopsy and the two tests. The Sensitivity of EMA and TTG tests for celiac diagnosis is 92%. The specificity of EMA, TTG tests are 100% and 98.5%, respectively.
Conclusion: EMA-IgA serology with cut-off point of more than 66 together with TTG-IgA serology with cut-off point of above 30 can be helpful to distinguish a wide range of patients who need small-bowel biopsy.
Keywords: Celiac Anti-tissue Transglutaminase (TTG) Anti-endomysial (EMA)
Faranak Balaghi Inaloo, Roya Askari, Amir Hossein Haghighi, Kaveh Kashani, Paul Friedemann,
Volume 17, Issue 3 (May-Jun 2023)
Abstract
Background and objectives: Studies have reported contradictory results regarding the relationship between serum neurofilament light chain (NFL) and fatigue severity. The aim of our study was to investigate serum NFL and fatigue severity in patients with multiple sclerosis (MS) after home-based and outdoor Pilates training.
Methods: The study population consisted of 44 women with MS (aged 25 to 40 years) with an expanded disability status scale score of 2-5. The patients were randomly divided into three groups: home-based training (HPT, n=15), outdoor training (OPT, n=15), and a control group (n=14). The training groups performed Pilates exercises for 8 weeks individually at home and under the sun. Blood samples and completed Fatigue Severity Scale forms were taken 48 hours before the first session and after the 8-week intervention.
Results: The results showed that OPT caused a more notable increase in serum vitamin D (32.76±5.13, p<0.001) and a decrease in NFL (15.98±2.26, p <0.001) and FSS score (2.51±0.35, p<0.001) compared with HPT. Also, HPT lowered NFL (18.01±2.28, p<0.001) and FSS score (3.84±0.98, p<0.001) compared with the control group.
Conclusion: Pilates training can reduce NFL levels and FSS scores in women with MS. In addition, OPT is more effective than HPT in reducing NFL and FSS and increasing vitamin D levels.
