:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 7, Issue 3 (Autumn 2013) ::
mljgoums 2013, 7(3): 46-53 Back to browse issues page
Anti-Endomysial and Anti-Tissue Transglutaminase Serological Test Compared with Small Bowel Biopsy in the Diagnosis of Celiac Disease
M Shadman 1, S Abedian Kenari *2, A Alizadeh 3, M Kaveh 4, V Hosseini 5
1- MSc , , Mazandaran University of Medical Science, Sari, Iran
2- PhD , abedianlab@yahoo.co.uk
3- PhD
4- MSc
5- MD
Abstract:   (20555 Views)
Abstract Background and Objective: Celiac is an autoimmune disease that is characterized by an immune-system-related damage in the intestinal tissue after consumption of gluten. There is not any general agreement for gold standard. The Purpose of this study was the evaluation of specificity and sensitivity of anti-endomysial (EMA) and anti-tissue transglutaminase (TTG) serological test compared to small-bowel biopsy. Material and Methods: In the cross sectional study, we took blood specimen from 1825 patients with gastrointestinal disease. All the samples were tested by TTG and EMA kits using ELISA. The patients were studied in two groups. First, the individuals whom their serologic test was positive but their tissue condition was normal and second, those with positive serologic test with pathologic tissue results that show they have celiac disorder. Results: The mean of EMA and TTG shows that the level of antibodies in group 2 is significantly higher than that of the first group (P ≤0.001). There is positive correlation between modified marsh criteria of small-bowel biopsy and the two tests. The Sensitivity of EMA and TTG tests for celiac diagnosis is 92%. The specificity of EMA, TTG tests are 100% and 98.5%, respectively. Conclusion: EMA-IgA serology with cut-off point of more than 66 together with TTG-IgA serology with cut-off point of above 30 can be helpful to distinguish a wide range of patients who need small-bowel biopsy. Keywords: Celiac Anti-tissue Transglutaminase (TTG) Anti-endomysial (EMA)
Keywords: Celiac, Anti-tissue Transglutaminase (TTG), Anti-endomysial (EMA)
Full-Text [PDF 882 kb]   |   Full Text (HTML) [English Abstract]   (1711 Downloads)    
Type of Study: Original Paper | Subject: Special
Received: 2013/06/26 | Accepted: 2013/09/29 | Published: 2013/09/29
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shadman M, Abedian Kenari S, Alizadeh A, Kaveh M, Hosseini V. Anti-Endomysial and Anti-Tissue Transglutaminase Serological Test Compared with Small Bowel Biopsy in the Diagnosis of Celiac Disease. mljgoums. 2013; 7 (3) :46-53
URL: http://goums.ac.ir/mljgoums/article-1-304-en.html
Volume 7, Issue 3 (Autumn 2013) Back to browse issues page
مجله علوم آزمایشگاهی دانشکده پیراپزشکی گرگان Medical Laboratory Journal
Persian site map - English site map - Created in 0.047 seconds with 798 queries by yektaweb 3531