Mon, May 7, 2018
Volume 7, Issue 4 (winter[PERSIAN] 2014)
mljgoums 2014, 7(4): 13-18 |
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Sharifi A, Razmi N, Naghsh N. The Antioxidant Effect of Camellia Sinesison on the Liver Damage Induced by Tioacetamide in Male Mice . mljgoums. 2014; 7 (4) :13-18
URL: http://goums.ac.ir/mljgoums/article-1-339-en.html
URL: http://goums.ac.ir/mljgoums/article-1-339-en.html
1- BSc MSc Student of Biochemistry, Department of Biology, Fars Branch, Islamic Azad University, Shiraz, Iran , sharifi_1385@yahoo.com
2- PhD Associate Professor of Medical Biochemistry, Department of Biology, Fars Branch, Islamic Azad University, Shiraz, Iran
3- PhD Assistant Professor of Physiology, Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2- PhD Associate Professor of Medical Biochemistry, Department of Biology, Fars Branch, Islamic Azad University, Shiraz, Iran
3- PhD Assistant Professor of Physiology, Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Abstract: (6039 Views)
Abstract
Background and Objective: Flavonoids play an important role in non-enzymatic reaction against oxidative stress. These are polyphenolic compounds in tea structure that could be reacted with free radicals and neutralized them. In this study, we investigated the anti-oxidant impact of Camellia Sinesis on the liver of thioacetamide -injected male albino mice.
Material and Methods: In this study, 40 male mice were categorized in five groups of eight. The first group was control. The second and the third group received 100mg/kg and 150mg/kg of thioacetamide, respectively. The fourth group received 100mg/kg thioacetamide followed by black tea (5 gr/100) and the fifth one received 150mg/kg thioacetamide followed by black tea (5 gr/100). Tioacetamide was given via intraperitoneal. After that, for 30 days, they were only fed on black tea (5 gr/100). At the end, catalase (CAT) and glutathione peroxidase (GPx) activity were measured.
Results: Based on the results, catalase(CAT) and glutathione peroxidase(GPx) activity were significantly increased in the groups of Thioacetamide and black tea compared to those of only Thioacetamide groups (p<0.05).
Conclusion: The increase of these enzymes in tea groups shows the anti-oxidant effect of black tea that can be caused by Catechin.
Keywords: Antioxidant Thioacetamide Black Tea Glutathione Peroxidase Catalase
Type of Study: Original Paper |
Subject:
Special
Received: 2013/09/11 | Accepted: 2013/10/29 | Published: 2013/10/29
Received: 2013/09/11 | Accepted: 2013/10/29 | Published: 2013/10/29
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