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1- Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran, Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
3- Medical Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Medical Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran , hr_joshaghani@yahoo.com
Abstract:   (1068 Views)
Background and Objective: Breast cancer is the second most common cause of mortality in women; therefore, the identification of novel putative markers is required to improve its diagnosis and prognosis. Estrogen receptor (ER) and progesterone receptor (PR) are routinely available in breast cancer specimens. (ER)  Semi quantitative assessment of ER and PR is important for prognosis. Even with the development of genomic tests, hormone receptor status remains the most significant predictive and prognostic biomarker. Also, Selenium is known to protect mammary epithelial cells from oxidative DNA damage to inhibit the initiation phase of carcinogenesis by apoptosis regulation. Since, the majority of breast cancers show over expression of ER and PR, we determined the Association of tissue selenium level and ER and PR expression in breast cancer.
Methods: 60 tissue samples (30 tumors and 30 tumor margins) were collected and examined for selenium level using graphite atomic absorption and ER/PR expression using immunohistochemistry (IHC).
Results:About 60% of the samples were positive for ER / PR expression. Mean level of tissue selenium in tumors for positive and negative ER/PR was 209.54 µg/l and 243.39 µg/l, respectively. So, there was no significant association between selenium level and ER/PR expression. (p>0.005)
Conclusion:There is no Association of tissue selenium level and ER/PR expression in breast cancer.
Keyword:Selenium, ER, PR, breast cancer
Keywords: Selenium, ER, PR, breast cancer
     
Type of Study: Original Paper | Subject: Special
Received: 2018/06/30 | Accepted: 2018/06/30 | Published: 2018/06/30

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