Volume 12, Issue 3 (May-Jun 2018)                   mljgoums 2018, 12(3): 30-33 | Back to browse issues page


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kheiri S, nematollahi Z, Gholipour N, Asadi J. Lack of Association of SP110 Gene Polymorphisms with Pulmonary Tuberculosis in Golestan Province, Iran. mljgoums. 2018; 12 (3) :30-33
URL: http://mlj.goums.ac.ir/article-1-1077-en.html
1- Department of Medical Biotechnology, Faculty Of Advanced Medical Technologeis, Golestan University Of Medical Science, Gorgan, Iran
2- Metabolic Disorders Research Center, Golestan University of Medical Science, Gorgan, Iran
3- Student Of National Institute Of Genetic Engineering and Biotechnology , Tehran, Iran
4- Metabolic Disorders Research center, Golestan University of Medical Science, Gorgan, Iran
Abstract:   (5037 Views)
ABSTRACT
          Background and Objectives: Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis, a main public health problem that results in 1.5 million deaths annually. A number of epidemiological studies suggested that host genetic factors could play a main role in susceptibility to tuberculosis infection.
SP110 is an interferon-induced nuclear body protein with vital roles in apoptosis, cell cycling and immunity. SP110 gene has been suggested to be a suitable candidate for limiting TB infections. Thus, we investigated the possible association between SP110 gene polymorphisms and susceptibility to tuberculosis in the Golestan Province, Iran.
          Methods: We investigated the frequency of rs1135791 polymorphism of the SP110 gene among 100 pulmonary tuberculosis patients and 100 healthy individuals who were referred to the health centers in the Golestan Province (Iran) between 2014 and 2015. Frequency of genotypes was evaluated using amplification refractory mutation system-polymerase chain reaction.
          Results: The frequency distribution of TT, TC and CC genotypes among the patients was 65%, 31% and 4%, respectively. In the control group, the frequency distribution of TT, TC and CC genotypes was 56%, 46% and 7%, respectively. There was no significant difference in the frequency of rs1135791 between the patients with pulmonary tuberculosis and the healthy controls (P=0.42).
          Conclusion:  Based on the results, the SP110 rs1135791 variant is not a genetic risk factor for development of pulmonary tuberculosis in Golestan Province, Iran.
          Keywords: rs1135791T, Pulmonary tuberculosis, Golestan Province.
Full-Text [PDF 590 kb]   (604 Downloads)    
Type of Study: Original Paper |
Received: 2018/04/30 | Accepted: 2018/04/30 | Published: 2018/04/30 | ePublished: 2018/04/30

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