Volume 12, Issue 3 (May-Jun 2018)                   mljgoums 2018, 12(3): 41-45 | Back to browse issues page

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Bokaeian M, Shahraki Zahedani S, Delarampoor A, Atashgah M, Dahmarde B. Evaluation of Antibiotic Resistance Patterns of Clinical Klebsiella pneumoniae Isolates from Educational Hospitals in Zahedan, Iran. mljgoums 2018; 12 (3) :41-45
URL: http://mlj.goums.ac.ir/article-1-1075-en.html
Evaluation of Antibiotic Resistance Patterns of Clinical Klebsiella pneumoniae Isolates from Educational Hospitals in Zahedan, Iran
Mohammad Bokaeian1 , Shahram Shahraki Zahedani1 , Abbasali Delarampoor 2, Mohammadreza Atashgah3 , Bahram Dahmarde3
1- Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Department of Microbiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2- Department of Microbiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , abbasalidelarami@gmail.com
3- Department of Microbiology, Faculty of Medicine, Zahedan University of Medical Science, Zahedan, Iran
Abstract:   (13015 Views)
ABSTRACT
Background and Objectives: The resistance of gram-negative bacteria to antibiotics has become a serious problem, which imposes a significant increase in treatment costs. Klebsiella pneumoniae is an important nosocomial pathogen from the Enterobacteriaceae family. The aim of this study was to investigate the frequency and pattern of antibiotic resistance in K. pneumoniae strains isolated from clinical samples.
Methods: This descriptive, cross-sectional study was performed on 150 K. pneumonia strains isolated from different clinical samples such as urine, sputum, blood, ulcers, lung secretions and abdominal abscess. Antibiogram test was performed using the disk diffusion method (Kirby-Bauer). Minimum inhibitory concentration of amikacin, tobramycin and gentamicin was determined via the E-test for 50 strains with high resistance rates.
Results: In this study, the highest rate of resistance was observed against carbenicilin, ceftriaxone, cefepime and streptomycin. K. pneumonia isolates were most frequent in urine and sputum samples. In the E-test, the highest rate of resistance was observed against gentamicin, tobramycin (16µg/ml) and amikacin (64µg/ml).
Conclusion: Based on our results, tigecycline, netilmicin, kanamycin and amikacin are the most effective antibiotics for the treatment of K. pneumoniae infections.
Keywords: Klebsiella pneumoniae, antimicrobial resistance, E-test method
Keywords: Klebsiella pneumoniae, antimicrobial resistance, E-test method
Full-Text [PDF 662 kb]   (1633 Downloads)    
Research Article: Original Paper |
Received: 2018/04/30 | Accepted: 2018/04/30 | Published: 2018/04/30 | ePublished: 2018/04/30
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