Volume 12, Issue 3 (May-Jun 2018)                   mljgoums 2018, 12(3): 12-16 | Back to browse issues page

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Khandan del A, Ahani Azari A, Jamalli A, Ghaemi E A. Efficacy of Mupirocin Ointment in Eradication of Staphylococcus aureus Nasal Carriage in Intensive Care Unit Staff and Patients. mljgoums. 2018; 12 (3) :12-16
URL: http://mlj.goums.ac.ir/article-1-1074-en.html
1- Department of Microbiology, 5th Azar Hospital, Golstan University of Medical Sciences, Gorgan, Iran
2- Department of Microbiology, Gorgan branch, Islamic Azad University, Gorgan, Iran
3- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4- Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (10060 Views)
          Background and Objectives: Staphylococcus aureus is one of the most common causes of morbidity and mortality among intensive care unit (ICU) patients. Nasal carriage is one of the main routs of S. aureus transmission between hospital personnel and patients. The objective of this study was to evaluate the efficacy of mupirocin ointment in eradication of nasal carriage of S. aureus in the ICU staff and patients of Panje-Azar hospital in Gorgan, Iran.
          Methods: In the first three months of the study (January to March), the prevalence of S. aureus among ICU patients was determined by routine microbiological and biochemical testing. Nasal samples were taken from ICU staff and all patients recently admitted to the ICU. Mupirocin nasal ointment (2%) was applied for treatment of S. aureus nasal carriers. Post-treatment sampling was done after five weeks. During the next three months, the presence of S. aureus and rate of resistance to methicillin was evaluated in new patients admitted to the ICU using the method used previously.
          Results: Of 60 samples from the ICU staff, seven (11.7%) samples were positive for S. aureus. Moreover, of 240 samples from the ICU patients, two samples were found as S. aureus-positive. Of the nine S. aureus-positive isolates, only two (22.2%) were methicillin-resistant S. aureus (MRSA). In the pre-intervention sampling, only five samples (2.8%) were identified as S. aureus, two of which were MRSA. However, treatment with mupirocin ointment eradicated nasal carriage of S. aureus and no isolate was found after the intervention.
          Conclusion: Our finding showed that mupirocin nasal ointment is highly effective in eradication of S. aureus nasal carriage and subsequently contribute to reduction in frequency of nosocomial infections in the ICU.
          Keywords: Intensive Care Units, Mupirocin, Nasal, Staphylococcus aureus.
Full-Text [PDF 608 kb]   (1587 Downloads)    
Type of Study: Original Paper |
Received: 2018/04/29 | Accepted: 2018/04/29 | Published: 2018/04/29 | ePublished: 2018/04/29

1. Silva EC, Antas Md, Monteiro B Neto A, Rabelo MA, Melo FL, et al. Prevalence and Risk Factors for Staphylococcus aureus in Health-Care Workers at a University Hospital of Recife-PE. Braz J Infect Dis. 2008; 12(6): 504-8. [DOI:10.1590/S1413-86702008000600012]
2. Vinodhkumaradithyaa A, Uma A, Shirivasan M, Ananthalakshmi I, Nallasivam P, Thirumalaikolundusubramanian P. Nasal Carriage of Methicillin-Resistant Staphylococcus aureus among Surgical Unit Staff. Jpn J Infect Dis 2013; 62(3): 228-229.
3. de Carvalho MJ, Pimenta FC, Hayashida M, Gir E, da Silva AM, Barbosa CP, et al. Prevalence of methicillin-resistant and methicillin-susceptible S. aureus in the Saliva of health professionals. CLINICS. 2009; 64(4): 295-302. [DOI:10.1590/S1807-59322009000400005]
4. Treakle A, Thom KA, Furuno P. Bacterial contamination of health care workers white coats. Am J Infect Control. 2009; 37(2): 101-105. doi: 10.1016/j.ajic.2008.03.009. [DOI:10.1016/j.ajic.2008.03.009]
5. Bertman G, Katzung MD. Basic Pharmacology. NewYork: Mc Grow-Hill. 2016; 793-802.
6. Ojulong J. Mwambu TP, Jolobo M, Agwu E, Bwanga F, Najjuka C, et al. Prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) Among Isolates from Surgical site Infections in Mulago Hospital, Kampala, Uganda. The Internet Journal of Infectious Disease. 2009; 7.
7. Saderi H, Owlia P, Maleki Z, Habibi M, Rahmati N. Susceptibility to Vancomycin in Staphylococcus aureus Isolated From Patients of Four University-Affiliated Hospitals in Tehran. Iranian Journal of Pathology. 2008; 3: 161-166.
8. Forbe BA, Sahm DF, Weissfeld AS. Bailey & Scotts Diagnostic Microbiology. 14th ed. Mosby, New York. 2015; 172-213.
9. CLSI: Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 24th informational supplement. CLSI, Wayne, PA. M100-S21 2017; 31(1). 8: 161-165.
10. Louie L, Goodfellow J, Mathiew P, Glatt A, Louie M, Simor A. Rapid detection of Methicillin resistant Staphylococci from blood culture bottles by using a multiplex PCR assay. J Clin Microbiol. 2002; 40(8): 2786-2790. [DOI:10.1128/JCM.40.8.2786-2790.2002]
11. Rahimi-Alang S, Asmar M, Cheraghali F, Yazarlou S, Amini A, Shakeri F, et al. Frequency of methicillin resistant Staphylococcus aureus in healthcare workers in Gorgan. Zahedan J Res Med Sci (Tabib-e-shargh). 2011; 13(1): 17-22. [Persian]
12. Ruiz A, Mora M, Zurita C, Larco D, Toapanta Y, Zurita J. Prevalence of methicillin-resistant Staphylococcus aureus among health care workers of intensive care units in Ecuador. J Infect DevCtries. 2014; 8(1): 116-9. [DOI:10.3855/jidc.3535]
13. Khalili M, Moshref M, Sharifi M, Sadeh M, Sazmand A. Prevalence of Staphylococcus aureus (SA) and Methicillin resistant Staphylococcus aureus (MRSA) in personnel of Operation room of Shahid Sadoughi hospital, Yazd, Iran. Payavard Salamat. 2013; 6(5): 392-402. [Persian]
14. Shibabaw A, Abebe T, Mihret A. Nasal carriage rate of methicillin resistant Staphylococcus aureus among dessie referral hospital health care workers; dessie, Serag-Eldin AS, Amany TA, Noha GA, Mohamed EAA. Clinical and microbiological effect of linezolid on Methicillin resistant Staphylococcus aureus (MRSA)colonization inhealthcare workers in Egypt. Middle East J Sci Res. 2013; 15(10): 1440-9.
15. Northeast Ethiopia. Antimicrob Resist Infect Control. 2013; 2: 25. doi: 10.1186/2047-2994-2-25. [DOI:10.1186/2047-2994-2-25]
16. Mansouri Ghiasi MA, Nasrollahi Omran A, Hashemi M, RajabZade Kanafi P, Jahangiri Rad M. The prevalence of antibiotic resistance pattern of Staphylococcus aureus isolatedfrom nasal carriage of surgical ward's staff in Shahid Rajaee hospital of Tonekabon, Iran. Medical Laboratory Journal. 2013; 7(1): 35-39. [Persian]
17. Askarian M. Zeinalzadeh A, Japoni A, Alborzi A, Memish ZA. Prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus and its antibiotic susceptibility pattern in healthcare workers at Namazi Hospital, Shiraz, Iran. International Journal of Infectious Diseases. 2009; 13(5):e241-7. doi: 10.1016/j.ijid.2008.11.026. [DOI:10.1016/j.ijid.2008.11.026]
18. Sarmadian, h. Dydgr, f. Abtahi, h.2008. Comparison of mupirocin nasal cream effect of single-dose oral ciprofloxacin in the treatment of recurrent nasal carriers of Staphylococcus aureus in personnel in Valiasre. Journal of Medical Sciences, 2004: Vol. 11, No. 1, pp, 40-44.
19. Kalmeijer MD, Coertjens H, van Nieuwland-Bollen PM, Bogaers-Hofman D, de Baere GA, Stuurman A, et al. Surgical Site Infections in Orthopedic Surgery: The Effect of Mupirocin Nasal Ointment in a Double-Blind, Randomized, Placebo-Controlled Study. Clin Infect Dis. 2002; 35(4): 353-8. [DOI:10.1086/341025]
20. Doebbeling BN, Breneman DL, Neu HC, Aly R, Yangco BG, Holley HP Jr, et al. Elimination of S. aureus nasal carriage in health care workers: analysis of six clinical trials with calcium mupirocin ointment. Clin Infect Dis. 1993; 17(3): 466-74. [DOI:10.1093/clinids/17.3.466]

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