Volume 11, Issue 6 (Nov - Dec 2017)                   mljgoums 2017, 11(6): 7-11 | Back to browse issues page


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Parsa M, Ahmadi M, Dastmalchi H, Tehrani A. Antibacterial Effect of Silver Nanoparticles along with L-Arginine against P. aeruginosa. mljgoums. 2017; 11 (6) :7-11
URL: http://goums.ac.ir/mljgoums/article-1-1037-en.html
1- (PhD) Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , parsamina26@gmail.com
2- (PhD) Professor of Bacteriology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran, Professor of Bacteriology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
3- (PhD) Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
4- (PhD) Department of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran, Department of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Abstract:   (2266 Views)
 
ABSTRACT
         Background and Objectives: Nowadays, the prevalence of multidrug-resistant pathogens such as Pseudomonas aeruginosa is increasing worldwide. Many studies have been seeking new treatment strategies to treat infections caused by these microorganisms. Silver nanoparticles (AgNPs) along with L-arginine have significant antimicrobial effects and could be used as alternatives for ineffective drugs.
         Methods: In this study, the antibacterial activity of AgNPs, L-arginine and various concentrations of AgNPs along with L-arginine (12.5 and 25 mg/ml) were investigated against P. aeruginosa PAO1 using the broth macrodilution method.
        Results: Minimum inhibitory concentration of AgNPs, L-arginine and AgNPs combined with 25 and 12.5 mg/ml L-arginine was 15.6 μg/ml, 25 mg/ml, 1.9 μg/ml and 3.9 μg/ml, respectively. Minimum bactericidal concentration of AgNPs, L-arginine and AgNPs combined with 25 and 12.5  mg/ml L-arginine was 31.2 μg/ml, 50 mg/ml, 3.9 μg/ml and 7.8 μg/ml, respectively.
       Conclusion: Our study suggests that AgNPs along with L-arginine can be used as an alternative antibacterial agent against P. aeruginosa, and might be useful for treatment of wound infections.
       Keywords: Nanoparticles, Arginine, Anti-Bacterial Agents, Pseudomonas aeruginosa
Full-Text [PDF 656 kb]   (362 Downloads)    
Type of Study: Original Paper | Subject: Special
Received: 2018/01/22 | Accepted: 2018/01/22 | Published: 2018/01/22

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