Volume 11, Issue 5 (Sep - Oct 2017)                   mljgoums 2017, 11(5): 33-35 | Back to browse issues page


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Komijani M, Kardi M T, Shahin K, Yazdi M. Detection of Mediterranean Hepatitis B in a 45 Years Old Man in Mahdieh Clinical Laboratory, Isfahan, Iran. mljgoums. 2017; 11 (5) :33-35
URL: http://goums.ac.ir/mljgoums/article-1-1016-en.html
1- (PhD) Department of Biology, Faculty of Science, Arak University, Arak, Iran, Department of Biology, Faculty of Science, Arak University, Arak, Iran
2- (PhD) Department of Microbiology, Mahdieh Laboratory, Isfahan, Iran, Department of Microbiology, Mahdieh Laboratory, Isfahan, Iran , m.kardi@gmail.com
3- State Key Laboratory Cultivation Base of Most, Institute of Food Safety and Nutrition, Jiangusa Academy of Agricultural Sciences, Nanjing 210014,PR China, State Key Laboratory Cultivation Base of Most, Institute of Food Safety and Nutrition, Jiangusa Academy of Agricultural Sciences, Nanjing 210014,PR China
4- MSc Department of Biology, Faculty of Sciences, University of Isfahan, 81746073441 Isfahan, IR Iran, Department of Biology, Faculty of Sciences, University of Isfahan, 81746073441 Isfahan, IR Iran
Abstract:   (1836 Views)
ABSTRACT
          Three major hepatitis B virus (HBV) antigens include HBcAg, HBeAg and HBsAg. HBeAg is the extracellular form of HBcAg, and is seen almost exclusively in people who have circulating serum HBV DNA. Presence of HBsAg in serum indicates that the individual has contracted HBV infection. Chronic hepatitis HBeAg-negative/anti-HBe–positive is known as an important form of chronic hepatitis B in the Mediterranean region. In this report, we used Real-Time PCR and ELISA for detection of HBV and HBeAg/HbsAg, respectively. In our investigation on 4743 HBV cases referred to the Mahdieh Clinical Laboratory between 2008 and 2016, we found a 53-year-old man with clinical symptoms of hepatitis and abnormal molecular and serological features. Despite the presence of clinical symptoms and high viral load (128 × 105 iu/ml), the patient was HBsAg-positive and HBeAg-negative. Identifying this type of HBV could indicate spread of this type of hepatitis in Isfahan, Iran.
           Keywords: Hepatitis B, HbsAg, HBeAg.
Keywords: Hepatitis B, HbsAg, HBeAg.
Full-Text [PDF 392 kb]   (253 Downloads)    
Type of Study: Original Paper | Subject: Special
Received: 2017/11/15 | Accepted: 2017/11/15 | Published: 2017/11/15

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