TY - JOUR T1 - Effect of High-Intensity Interval Training on the Gene Expression of Eotaxin in Visceral Adipose Tissue and Insulin Resistance Following Metabolic Syndrome in Rats TT - اثر تمرین تناوبی با شدت بالا بر بیان ژن ائوتاکسین بافت چربی احشایی و مقاومت به انسولین به دنبال سندرم متابولیک در موش‌های صحرایی JF - J-Gorgan-Univ-Med-Sci JO - J-Gorgan-Univ-Med-Sci VL - 23 IS - 4 UR - http://goums.ac.ir/journal/article-1-3928-en.html Y1 - 2021 SP - 18 EP - 25 KW - Eotaxin KW - Metabolic Syndrome KW - High-Intensity Interval Training KW - Insulin Resistance KW - Rat N2 - Background and Objective: Eotaxin is a pre-inflammatory adipokinin secreted from adipose tissue that plays an important role in function regulating of adipose tissue. This study was done to determine the effect of high-intensity interval training on the gene expression of eotaxin in visceral adipose tissue and insulin resistance following metabolic syndrome in rats. Methods: In this experimental study, 40 male Wistar rats (weight 180±20 gr) were selected and after 12 weeks of high-fat diet and the creation of the metabolic syndrome model were randomly divided into four groups including control, metabolic syndrome, High-Intensity Interval Training (HIIT) and metabolic syndrome with HIIT. Rats in the high-fat diet were subjected to a special diet (30 to 40% fat) for 12 weeks to develop a model of metabolic syndrome. HIIT consisted of 5 to 10 interval 1-minute intensive running on treadmill at 80 to 95% of maximum speed and in slow alternations at 55% of maximum speed for 8 weeks. Insulin resistance using HOMA-IR mode is considered as a basic factor for determining metabolic syndrome. Results: The gene expression of eotaxin and insulin resistance in the metabolic syndrome group were significantly higher than the control group (P<0.05). Gene expression of eotaxin and insulin resistance was significantly lower in HIIT and metabolic syndrome with HIIT groups than the metabolic syndrome group (P<0.05). Also, the gene expression of eotaxin and insulin resistance was significantly lower in HIIT group than the metabolic syndrome with HIIT group. Conclusion: It seems that HIIT may be an important factor in down-regulating eotaxin and insulin resistance in metabolic syndrome. M3 ER -