TY - JOUR JF - J-Gorgan-Univ-Med-Sci JO - J Gorgan Univ Med Sci VL - 22 IS - 2 PY - 2020 Y1 - 2020/6/01 TI - Effect of resistance training and Resveratrol supplementation on muscle regeneration of MyoD and eMHC in CT-26 colon cancer mice TT - اثر تمرین مقاومتی و مکمل یاری رسوراترول بر شاخص‌های باززایی عضلانی MyoD و eMHC در موش‌های سوری مبتلا به سرطان کولون CT-26 N2 - Background and Objective: Physical exercise and nutrition supplements are recommended interventions to reduce cachexia. This study was conducted to determine the effect of resistance training and resveratrol supplementation on muscle regeneration indices of MyoD (myoblast determination protein) and eMHC (embryonic Myosin Heavy Chain) in CT-26 colon cancer mice. Methods: This experimental study was performed on 20 six-week-old BALB/c mice to which CT-26 tumor was implanted. The mice were divided into four groups of resistance training, resveratrol, combination of resveratrol with resistance training, and control. The resistance training group performed six weeks of progressive resistance training. The resveratrol group received 100 mg/kg resveratrol per day, and the control and resistance training group received the solution of Methyl cellulose through gavage. In gastrocnemius muscle MyoD protein and eMHC level were measured using western blot and ELISA methods, respectively. Results: eMHC protein in combination of resveratrol with exercise group (4.66±0.25) increased significantly compared to the exercise group (3.46±0.64) (P<0.05). Body weight of mice without tumor (21.50±1.30) in the resistance training group increased significantly compared to other groups (P<0.05). There was no significant difference in the tumor weight of mice and MyoD protein in expermental groups. Conclusion: Regarding the increasing effect of combination of resveratrol with exercise group compared to resistance training group on eMHC, resveratrol supplementation at higher doses may be recommended along with resistance training to improve muscle regeneration. SP - 40 EP - 48 AU - Asadmanesh, Enayatollah AU - Koushkie Jahromi, Maryam AU - Samadi, Mahdi AU - Daryanoosh, Farhad AU - Neamati, Javad AD - Associate Professor of Exercise Physiology, Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran KW - Resistance Training KW - Resveratrol KW - MyoD Protein KW - Cancer UR - http://goums.ac.ir/journal/article-1-3637-en.html ER -