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Showing 2 results for Vitamin D Deficiency
Masoumeh Habibian ,
Volume 26, Issue 4 (12-2024)
Abstract
Vitamin D deficiency affects a broad range of health-related factors. Both obesity and vitamin D deficiency are associated with the development of oxidative stress and systemic inflammation. Inflammation can culminate in decreased vitamin D levels through the induction of oxidative stress. Evidence suggests that exercise may improve vitamin D status. However, the effects of exercise interventions on inflammation and oxidative stress in the coexistence of vitamin D deficiency and obesity/overweight are not well-established. Therefore, this review aimed to evaluate the effects of exercise on inflammation and oxidative stress in vitamin D deficiency status accompanied by obesity/overweight. A search for articles from 2006 to 2023 was conducted in specialized databases of PubMed, Scopus, and state inpatient database (SID). The searched studies were original research articles, reviews, and clinical trials selected using the keywords of vitamin D deficiency, systemic inflammation, oxidative stress, chemokine, exercise, obesity, and overweight. According to the studies, regular exercise can inhibit the vicious cycle of oxidative stress-inflammation in vitamin D deficiency status accompanied by obesity/overweight by negatively regulating some inflammatory factors and chemokines, reducing lipid peroxidation levels, and increasing antioxidant status. Moreover, the increase in 25-hydroxyvitamin D levels resulting from exercise can be considered another mechanism for reducing oxidative stress-inflammation in vitamin D deficiency status accompanied by obesity/overweight.
Marzieh Noshirvanpour Kochaksaraie , Hossain Arabzadeh , Masoumeh Habibian ,
Volume 27, Issue 3 (10-2025)
Abstract
Background and Objective: Vitamin D deficiency is highly prevalent among obese individuals, with multiple underlying mechanisms contributing to this condition. This study aimed to determine the combined effects of high-intensity interval training (HIIT) and vitamin D supplementation on the levels of inflammatory markers, transforming growth factor beta 1 (TGF-β1) and tumor necrosis factor alpha (TNF-α), in young women with vitamin D deficiency.
Methods: In this clinical trial, 39 sedentary women with vitamin D deficiency were randomly assigned to three groups: A control group, a HIIT-based running group, and a combined group (training + vitamin D). The training program included 12 one-minute repetitions of running at 80% to 90% of maximum heart rate (HRmax) and one minute of active rest at 50% HRmax, performed three sessions per week. Vitamin D supplementation was used weekly at a dose of 50,000 IU. TGF-β1 and TNF-α levels were measured and compared before and after the intervention.
Results: After 8 weeks of HIIT-based running, with and without vitamin D supplementation, the levels of inflammatory markers, TGF-β1 and TNF-α, showed a statistically significant decrease compared to the control group (P<0.05). The mean percentage change in TGF-β1 and TNF-α was also significantly greater in the combined group than in the training group without vitamin D supplementation (P<0.05).
Conclusion: Following 8 weeks of HIIT-based running, both inflammatory markers, TGF-β1 and TNF-α decreased in the study subjects, and this reduction was more pronounced in the vitamin D-receiving group.
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