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Showing 2 results for Single Nucleotide Polymorphisms
Yousef Khanjari , Alijan Tabarraei , Morteza Oladnabi, Nafiseh Abdolahi ,
Volume 20, Issue 1 (3-2018)
Abstract
Background and Objective: Single Nucleotide Polymorphisms in programmed cell death which expressed at high level in T cells, plays an important role in the development and cause autoimmune disorders. This study was done to evaluate the frequncy of rs11568821 polymorphism in patients with systemic lupus erythematosus (SLE).
Methods: This case-control study was done on 76 patients with SLE and 56 healthy controls. After DNA extraction, frequncy of polymorphisms PDCD1.3 by polymerase chain reaction and sequencing methods in subjects were determined.
Results: There was a significant diference between frequency of allele and genotype at rs11568821 Polymorphism in region of intron 4 of PDCD1.3 gene in case and control groups (P<0.05). A allele and AG genotype was significantly higher in patients than healthy controls (9.5% vs 0.09%, P<0.05). There was no significant association between clinical and laboratory findings with genotype frequencies.
Conclusion: rs11568821 single nucleotide polymorphism in intron 4 gene region PDCD1 can be used as a genetic factor to be involved the SLE susceptibility.
Golnoosh Tolue , Seyed Abdolhamid Angaji , Behnaz Beikzadeh , Hengameh Alibeik , Raheleh Roudi, Behzad Narouie ,
Volume 25, Issue 3 (10-2023)
Abstract
Background and Objective: Prostate cancer is a malignancy affecting men. Identifying risk factors for prostate cancer is crucial for the potential development of interventions and expanding our biological understanding of this disease. The present study investigated the association of rs1800896 and rs1800896 with prostate adenocarcinoma.
Methods: This case-control study was conducted on 176 men, including 78 patients with prostate adenocarcinoma (case group) and 98 men with benign prostatic hyperplasia (control group), who visited the Labafinejad Educational and Treatment Center in Tehran, Iran. Genotyping was performed using the Tetra ARMS-PCR (amplification refractory mutation system-polymerase chain reaction) method.
Results: There was no statistically significant difference between the case and control groups in the genotype frequency of rs1800896 and rs1465618. However, the rs1800896 polymorphism was associated with PSA levels less than or equal to 4 ng/mL (P<0.05). Significant associations were found between rs1800896 and rs1465618 polymorphisms and clinical features, such as perineural invasion (P<0.05).
Conclusion: The rs1800896 and rs1465618 polymorphisms were not associated with the risk of prostate adenocarcinoma.
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