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Background and Objective: In recent years many studies have reported that aspirin could have beneficial effect on learning and memory in different diseases of central nervous system. The objective of present study was to explore the effect of aspirin on learning and memory of Rats in pentylenetetrazole kindling model. Materials and Methods: In this experimental study Rats were divided randomly into six groups (n=8). Animals in three groups received aspirin (15 and 30 mg/kg, orally) and saline, one week before and during induction of kindling, respectivley. Kindling was induced in these groups by administration of pentylenetetrazole (PTZ: 40 mg/kg, ip). Two groups of animals received only aspirin 25 and 30 mg/kg orally. Other group received only saline throughout the study and served as health control group. After induction of kindling the learning and memory of Rats was tested in shuttle box. Study was divided to three stages of adaptation, acquisition and retention test. Initial Latency (IL) time before electrical shock and Step through latency (STL) time, 20 min or 24h after acquisition was evaluated as learning and memory index. Locomotor activity was also evaluated in open filed test. Results: PTZ kindling significantly decreased Initial Latency and Step through latency time, 20 min or also 24h after acquisition, and aspirin significantly increased these times in kindled animals (p<0.05). Aspirin also had no significant effect on locomotor activity of animals. Conclusion: This study showed that the administration of aspirin to kindled Rats improved learning and memory impairments induced by pentylenetetrazole kindling.

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Background and Objective: Learning is the acquisition of information that makes this possible, and memory is meant to store this information. Millet contains proteins, minerals, vitamins and antioxidants needed to preserve the life and health of mammalian cells. This study was conducted to determine the effect of alcoholic extracts of seed of millet (Panicum miliaceum L.) on spatial memory in mice.
Methods: In this experimental study, 24 male rats were randomly allocated into 4 groups. Hydrochloric extract of Prossu millet was prepared by Soxhlet method and injected into three treatment groups with doses of 25, 50 and 75 mg/kg/bw by intraperitoneal injection for 21 days. Animals in control group were received normal saline. After one month from the first injection, learning behaviors and memory tests were performed. Mauritius water maze was used to evaluate the spatial memory. Also, shuttle box method was used to determine passive avoidance of spatial memory.
Results: The results showed that the mean time for finding the platform between the control group and alcoholic treatments in doses of (75 mg/kg/bw) was significantly different (P<0.05). Also, the mean time of training and test time in control and treatment groups receiving alcoholic extract showed a significant difference, indicating that this extract had a significant effect.
Conclusion: Alcoholic extract of millet seed with dosage of 75 mg/kg/bw improves the learning and spatial memory of male mice.