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Background & Objective: In most cases, labor is accompanied with pain. Thus, decreasing labor pain is viewed as an important duty of midwives. In this regard, decreasing the duration of labor can be of value. Customarily midwives use drugs to shorten the duration of labor, but the effectiveness of some of the drugs has not been studied systematically. Among such widely used drugs are Atropine, Hyoscine and Promethazine. Materials & Methods: In this interventional research, the effects of these drugs on labor duration were studied. 160 multiparous women in active phase of labor were selected. 120 of the above women had been administered only one of the above-mentioned drugs and no drug had been administered to the remaining 40. According to the type of drug administered, the women formed three groups, with the women with no drugs administered making the 4th groups. Results: The 4 groups did not have any statistically significant difference with regard to variables such as age, occupation, education, infant sex, gestational age, infant birth weight, parity, fetal head position, and cervical dilatation at the beginning of our observation. The main result was that, the mean rate of cervical effacement (P<0.05) and descent of fetal head was not significantly different in the 4 groups. But the mean rate of cervical dilatation (P<0.05) was significantly different in the 4 groups. In women who had been given these drugs, the mean rate of cervical dilatation was lower than the women who had not been given any drugs. The mean duration of the first stage of labor was significantly different in 4 groups (P<0.05). With regard to the mean duration of the first stage of labor, it was also longer in women who had been given these drugs. The mean rate of 2nd stage of labor and 3rd stage of labor was not significantly different in the 4 groups. Conclusion: The use of these drugs can reduce the rate of labor progress and increase the risk of complications, it may also be a waste of prescribed drugs.

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Background and Objective: Pain after tonsillectomy is one of the most common complications. This study was done to compare the effect of Gabapentin and promethazine as premedication to reduce pain after tonsillectomy.
Methods: This clinical trial study was performed on 104 patients aged 7-15 years who were candidate for tonsillectomy. Patients were randomly divided into gabapentin and promethazine groups. The first group received oral gabapentin 20 mg/kg/bw, and the second group was treated with promethazine syrup 0.5 mg/kg/bw one hour before anesthesia. Pain score was recorded based on the MOPS index and recorded and compared during 3, 6, 12, and 24 hours after surgery.
Results: The mean±SD of pain severity in the intervention group with promethazine at 3, 6, 12 and 24 hours after surgery were 1.35±0.84, 0.9±0.87, 0.25±0.52, 0.04±0.19, respectively. Pain severity was 1.58±0.98, 1.13±0.91, 0.69±0.27, and 0.06±0.24 in gabapentin group, respectively. There was no significant difference between pain score of two groups in 3, 6, 12 and 24 hours after surgery.
Conclusion: Gabapentin and promethazine as premedication have a similar analgesic effect in patients after tonsillectomy.