---

Background&Objective: The life time prevalence of schizophrenia is estimated about 1%-1.5% in United States and various studies have shown that between 7.8-46.6% of these patients suffer from OCD. The differences in these statistics are partly due to the assessment and treatment methods. The purpose of this study was to measure the frequency of OCD in hospitalized schizophrenic patients. Materials&Methods: The study was cross-sectional. 96 inpatients (56 men and 40 women) with DSM-IV schizophrenia diagnostic criteria were selected from Iran Psychiatry Hospital by simple non-random sampling Results: The age range of the patients were 17-73 with a mean age of 35 ±12.6. The majority of patients (88.5%) suffered from paranoid schizophrenia. 47 patients (49%) were diagnosed to have obsessive-compulsive symptoms on interview. The mean age of schizophrenia onset was 24.7 ±8.8 and the mean age of OCD onset in schizophrenic patients was 20.2 ±6.7. In 8 (17%), the two disorders were began simultaneously and in 20 (20.8%), schizophrenia was started earlier. Conclusion: Obsessive-compulsive symptoms are completely prevalent in schizophrenia. The co morbidity of these two clinical entities has both etiological and therapeutic importance.

---

Background & Objective: In spit of high prevalancey of the Obsessive-Compulsive Disorder in anxity diseases. It shows the least therapeutic responses. This study was done to determine The comparison of therapeutic effect of Naltrexone and Flouxetine on Obsessive-Compulsive Disorder (O.C.D).

Materials & Methods: This double-blind clinical trial study was done on 30 patients aged 18 to 60 years referring to the clinics of psychiatry at Zareh hospital in Sari-Iran during 2006. Patients in three groups, treated with flouxetine 53.9mg/d (group A) Naltrexone 64.4mg/d (groupe B) & Pelacebo (group C) in the same shape capsula respectively. The severity of O.C.D was evaluated at 4 steps with Yale-Brown scale.the obtained data were analyzed using parametric & nonparametric tests.

Results: Naltrexone reduced the severity of O.C.D symptoms significantly (45.01%) at the end of week 8^th (p<0.05). Same result (45.81%) was observed using Flouxetine (P=0.79). The rate of efficaey in both drugs significantly was higher than pelacebo (P<0.05).

Conclusion: This study showed thant, Naltrexone has the same level of reducting symptome of OCD but even with faster therapeutic effect than Flouxetin.