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Background&Objective: Considering the high prevalence of Tricomonas vaginalis (TV) in women and the known side effects of metronidazol, herbal drug therapy in order to reduce drug side effects has been considered increasingly in recent decades. This study was done to determine the effect of Artemisia aucheri Boiss, Zataria multiflora Boiss and Myrtus communis L. on Trichomonas vaginalis. Materials&Methods: This study was done on samples extracted from 100 patients with vaginitis due to Trichomona. The parasite was isolated from vagina and determined directly. Identification was done through direct smear preparation. Parasite was added to the 5 test tubes containing Dorse medium, metronidazole. dimethyl sulfoxaide (DMSO), Artemisia, Zataria and Myrtus extraction with concentration of 0.1, 0.01 ml in order to determine the effect of these concentrations within 72 hour. Results: Trichomonas could be alived in Dorse medium for 72 hours, in presence of metronidazole for one hour and in Dorse medium for 6 hours. Also, methonolic extracts of Artemisia are effective at concentration of 0.1 after one hour and 0,01 after 4 hours of the inoculation. Methanolic extracts of Zataria at concentrations of 0.1 and 0.01 and the Myrtus extract at concentration of 0.1 are effective at beginning of inoculation but the Myrtus extract at concentration of 0.01 is effective after one hour. Conclusion: Considering the acceptable effect of metanolic extracts of these plants on trichomonas in in-vitro conditions, it is recommended that , the therapeutic effects of the substances from these plants to be studied in in vivo conditions and in case of having positive effect to be used as a drug.

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Background and Objective: Candida albicans is the most frequent etiological agent of oral candidiasis. This study was done to compare the anticandidal effect of Thymus vulgaris and Myrtus communis to nystatin on Candida albicans. Materials and Methods: In this laboratory study thirty-two strains of Candida albicans isolated from patients with oral candidiasis. Yeast suspension of Candida yeast cells was provided, subsquntly a serial dilution from Thymus vulgaris and Myrtus communis and Nystatin in Sabouraud Dextrose Agar (SDA) medium were prepared. Then a loop of Candida suspension was cultured on all of the solid media and was incubated at 25°C. The findings of fungus growing were recorded during 7 days. Results: MIC of Thymus vulgaris, Myrtus communis L, mix of these essences and Nystatin was 0.390µl/ml, 12.5 µl/ml, 0.78 µl/ml and 160 IU/ml, respectively. Conclusion: Thymus vulgaris contained antifungal activity against Candida albicans, but Myrtus communis demonstrated a very low activity against Candida albicans.