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Cutaneous metastasis from carcinoma of the larynx are very rare. We observed a 75-year-old male patient with squamous cell carcinoma of the larynx who developed a subcutaneous nodule as an abscess presentation in the buttock. It was found to be a metastatic squamous cell carcinoma of the laryngeal cancer, histopathologically. The skin manifestations proceeded laryngeal metastases by 18 months after laryngectomy and radical neck dissection. After 3 months, the patient died. Cutaneous metastasis of laryngeal carcinoma should be considered in all patients with previous laryngeal carcinoma representing with cutaneous lesion.

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Background and Objective: Colorectal carcinoma accounts for nearly 10% of all incident cancers. The stage of the disease is the most important prognostic factor. The main purpose of this study was to evaluate the effect of some presumed prognostic factors on the survival rate of patients with nonmetastatic rectal adenocarcinoma.

Materials and Methods: In this retrospective cohort study, 76 patients (m/f:40/36) with nonmetastatic rectal adenocarcinoma whome were referred to oncology department of Omid Hospital between 2001-06 were evaluated. All patients underwent surgical resection and those with T3-T4 and/or lymph node involvement received adjuvant radiotherapy and chemotherapy. Disease free survival was assessed from the date of diagnosis to the date of recurrence using Kaplan-Meyer method. Log-rank test was used to compare survival curves between groups. Multivariate analysis was performed using stepwise backward Cox Proportional Regression method.

Results: Stages 1, 2 and 3 were detected in 4, 34 and 38 cases. 48 patients had well differentiated tumors. 11 cases presented with obstruction. With a median follow up time of 18 months, 17 patients experienced recurrence. For all cases 3-year survival rate was 68.2%. The 3-year survival rate was significantly better for stage 1,2 compared to stage 3, patient without obstruction compared to those presented with obstruction, cases older than 50 compared to younger patients and patients with well differentiated tumor compared to moderately or poor differentiated tumors (P<0.05). The gender and the site of tumor had not significant effects on survival. In multivariate analysis only stage of the disease remained significant predictor of survival (p<0.05).

Conclusion: This study confirmed that the stage of the disease is the most important predictor of survival. Although younger ages (<50), moderately or poorly differentiated tumor and presence of obstruction at diagnosis were associated with decreased survival in univariate calculations, they lost their significance in multivariate analysis.

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Background and Objective: The vertebra is the most common site of bone metastases. Diagnosis of metastases particularly in the early stages can improve patients’ prognosis and therapy. This study was done to compare the diagnostic value of magnetic resonance imaging and bone scan for the diagnosis of vertebral metastases. Methods: This descriptive study was done on 43 patients with any types of primary cancer. Patients underwent spinal magnetic resonance imaging and nuclear scan. Bone scan results were considered as the gold standard. The sensitivity and specificity were calculated for magnetic resonance imaging and nuclear scan. Results: The magnetic resonance imaging diagnosed 19 cases of thoracic vertebral metastases which previously diagnosed as negative by bone scan. Sensitivity and specificity of magnetic resonance imaging compared to bone scan was 90.7% and 95.6%, respectively. The magnetic resonance imaging diagnosed 4 cases of lumbar vertebral metastases which were reported negative in bone scan. Sensitivity, specificity and accuracy of magnetic resonance imaging in compare to bone scan were 97.6%, 97% and 97.2%, respectively. Conclusion: In diagnosis of vertebral metastases, the magnetic resonance imaging is more sensitive than bone scan.