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Showing 2 results for Mhc
E.alijani (m.sc), M.shekarabi (ph.d), M.kamgooyan (m.sc), S.arshi (m.d), M.jafari-Modrek (m.sc),
Volume 4, Issue 2 (9-2002)
Abstract
Major histocompatibility complex (MHC), which plays a major biological function in immune response, is generally associated with so many human disease. During recent years a new clinical relevance of MHC disease. On the other hand there is a strong correlation between some autoimmune diseases and MHC system such as in some allergic abnormalities and its relation with HLA antigens. In order to investigate this concept 30 atypic asthmatic patients and 100 healthy controls were selected. Human leukocyte antigen (HLA) typing was performed by standard NIH procedures and the results analyzed. The frequency of HLA-A2, A11, Aw19 and HLA-B51 decreased in atypic asthmatic patients with no association recorded significantly between HLA-C and allergic asthma. The results of our study indicated that there was a significant relationship between allergic asthma and HLA-I antigens.
Banitalebi E (phd), Ghatre Samani K (phd), Mardani G (msc), Soheili A (pharm.d), Ansari Samani R (msc), Teimori H (phd),
Volume 14, Issue 4 (12-2012)
Abstract
Background and Objective: Sphingosine-1-phosphate (S1P) is involved in regulation of proliferation, differentiation, hypertrophy and anti-apoptosis and activation of satellite cells. This study was done to evaluated the effect of 8 weeks resistance training on sphingosine-1-phosphate level and gene expression of SK1 enzyme, isoforms of MHCs in skeletal muscles of male Wistar rats. Materials and Methods: This experimental study was done on Twenty four 8-week-old 190-250 gr male Wistar rats. The rats were allocated randomly into control (N=12) and training (N=12) groups. Resistance training was done using a 1 meter height ladder with 2 cm grid with an 85 degree incline, and weights attached to rat's tails. The content of S1P present in the chloroform layer was determined by means of high performance liquid chromatography (HPLC). Determination of relative mRNA expression was performed by Real-time PCR. Data were analyzed using SPSS-17, Kolmogorov-Smirnov and independent t-test. Results: Resistance exercise training increased the total content of S1P in FHL (fast-twitch) and soleus (slow-twitch) muscles in comparison with control group (P<0.05). Resistance exercise training changed the gene expression of FHL SK1, SOL SK1, FHL MHC I, Sol MHC I, FHL MHC IIa, Sol MHC IIa, FHL MHC IIb, Sol MHC IIb, FHL MHC IIx, Sol MHC IIx in comparison with control group (P<0.05). Conclusion: This study showed that S1P level and gene expression of SK1, MHCs increased at skeletal muscles after training.
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