|
|
|
 |
Search published articles |
 |
|
Showing 3 results for Lymphocyte
Ghafourian Brooujerdnia M, Esmaielvandi K, Saffarfar V, Saadati N,
Volume 13, Issue 1 (3-2011)
Abstract
Background and Objective: Many different factors and problems can cause infertility. This study carried out to compare NK, T and B lymphocyte populations in peripheral blood of fertile and infertile women.
Materials and Methods: In this case - control study 30 infertile women and 15 non pregnant women participated. The non pregnant women had a history of at least two alive children as a control group. The monoclonal antibodies and flowcytometry were used for evaluation of T cell subpopulations (CD3, CD4, CD8), B cells (CD22) and NK cells (CD56) in fertile and infertile women.
Results: NK cells (CD56) significantly increased in infertile women compared with control groups (P=0.009) and T lymphocytes CD3, CD4 significantly reduced in infertile women compared with fertile women (P=0.013, P=0.004, respectively). CD4/CD8 ratio reduced in infertile women compared with fertile women (P=0.05). There was no difference in B cells and CD8 T cells in infertile women compared with controls.
Conclusion: This study showed that NK cells increase and CD4 T lymphocytes reduce in infertile women. Our results suggest the immunological alterations may be related to infertility.
Norizadeh Tazehkand M , Topaktas M, Hajipour O,
Volume 17, Issue 2 (7-2015)
Abstract
Background and Objective: Mirtazapine is a norepinephrine and serotonergic antidepressant that is used in the theraphy of major depressive disorders. This study was carried out to determine the genotoxic and cytotoxic effect of mirtazapine using chromosome aberration and mitotic index tests in human peripheral blood lymphocytes. Methods: In this descriptive -analytic study genotoxic and cytotoxic effect of mirtazapine at 24 and 48 hours treatment periods on four concentration (10, 25, 40, and 55µg/ml) was performed on peripheral blood lymphocyte of four subjects. Results: Mirtazapine significantly reduced the mitotic index in the all concentrations but it non-significantly increased the chromosome aberration at 24-hours and 48-hours treatment periods. Conclusion: Mirtazapine has cytotoxic effect but it has no genotoxic effect on human lymphocyte.
Mojtaba Zare Ebrahimabad , Hanieh Teymoori , Amir Houshang Poorkhani , Naser Behnampour , Hamid Reza Joshaghani ,
Volume 19, Issue 4 (12-2017)
Abstract
Background and Objective: Venous thromboembolism (VTE) is a common clinical condition with a mortality rate of 15-20%. Neutrophil to lymphocyte ratio (NLR) is known as an indicator in predicting clinical outcomes in patients with various diseases and malignancies. This study was conducted to determine the value of neutrophil to lymphocyte ratio in the prognosis of death in patients with venous thromboembolism during the short term.
Methods: This retrospective cohort study was performed on 93 hospitalized patients with spontaneous venous thromboembolism in Gorgan, northern Iran during 2012-15. Demographic, blood and biochemical parameters of the patients were evaluated in the prediction of fatal outcome in a follow-up of 30 days after thrombose diagnosis.
Results: Sixteen patients (17.2%) died within 30 days. The variables of age, white blood cells, neutrophils, NLR, creatine kinase MB and lactate dehydrogenase significantly increased (P<0.05), and lymphocyte also platelet significantly reduced within the occurrence of death in a short period of 30 days follow up (P<0.05). A cut-off point of 7.21≤NLR had sensitivity, specificity, positive and negative predictive value of 56.3%, 87%, 47.3% and 90.5%, respectively.
Conclusion: Neutrophil to lymphocyte ratio can be used as a useful biomarker in the prediction of mortality during short periods of time in VTE patients.
|
|
