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Showing 2 results for Leukocytosis
B.khodabakhshi (m.d), M.haidari (m.d), M.r.faseli (ph.d), E.ghaemi (ph.d), M.sadeghkarimi (m.d),
Volume 3, Issue 2 (9-2001)
Abstract
Gastro-enteritis due to Vibrio Cholera was increased suddenly in summer of 1998 in our country. In this research we studied epidemiological and clinical features of Cholerae patients. Vibrio Cholera isolated from 189 (3.3%) patients from 56II stool samples. 182 (96.2%) Vibrio Cholera O1 isolated. 46 (24%) patients with positive stool cultures for Vibrio Cholera were hospitalized. 50% patients were 15-45 yrs. No sex predominency was seen. The important observations in this study including: Fever in 28.1% (13) of patients, sever leukocytosis in 15% (7) of patients, RBC in stool in 33% (15) of patients. Fever and neutrophilia and RBC in stool probably shows co-infection with order intestinal pathogens or different serotypes of Vibrio Cholera with new characteristics. So we are recommending extensive research to be done on serotyping of all of the isolates of Vibrio cholera and other intestinal pathogens simultaneously.
Sanaat Z, Shams K, Nejati B, Movasghpour Ak , Imani V, Moghadaszadeh M,
Volume 16, Issue 4 (12-2014)
Abstract
Background and Objective: The acute myeloid leukemia (AML) is a malignant disease with an accumulation of the abnormal and undifferentiated blastic myeloid cell in the bone marrow, leading to abnormal hematopoiesis. This study was done to determine the NPM1 and FLT3-(ITD) mutations and laboratory findings in patients with acute myeloid leukemia. Methods: This descriptive-analytic study was carried out on 40 (24 males, 16 females) patients with newly acute myeloid leukemia in Northwest of Iran. The mutation of NPM1 and FLT3-ITD were evaluated using PCR method in 25 patients. In all patients, the flowcytometry findings in the bone marrow, leucocytosis and the LDH levels were evaluated prior to the chemotherapy. Results: The mutation of FLT3-ITD and NPM1 genes was detected in 15 (60%) and 9 (36%) of patients, respectively. FLT3-NPM1+ mutation was seen in 4 (16%) patients. Leukocytosis, LDH level and AML in different classes did no show any significant difference between FLT3-NPM1+ and other gene mutations. Conclusion: The mutation of FLT3-ITD gene was nearly twice than NPM1 in acute myeloid leukemia.
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