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Background and Objective: Extensive exercise may be disrupting oxidant and antioxidant balance and cause the phenomenon of oxidative stress in human and decrease athletics performance. This study was done to determine the effect of coenzyme Q10 supplementation for two weeks on markers of lipid peroxidation in soccer player. Methods: In this queze – experimental study, 36 soccer players (mean age, 20.08±1.12 years, weight 63.28±1.65 kg and maximal oxygen uptake 53.12±0.98 ml per kg/bw) divided into three groups for 14 days and the desired experiment was done during this period of time. Soccer players in control group did not receive the supplements and exercise. Subjects in placebo group were received 5 mg/kg/bw aspartame capsules. Subjects in supplement group were received 5 mg/kg/bw of Ubiquinone-10. Soccer players also performed two 90-minute soccer matches with less than 48 hours. Blood samples 24 hours before and after the period were collected. Malondialdehyde (MDA), lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate aminotransferase (AST) levels were measured. Results: Serum level of MDA and AST after two consecutive football matches was significantly increased in the placebo group in compared to supplementation and placebo groups (P<0.05). The serum levels of AST and MDA in supplementation group did not significantly increased when compared to control and placebo groups. Conclusion: Short-term supplementation of coenzyme Q10 before and during of the two consecutive soccer matches can prevent the elevation of lipid Peroxidation indeces.

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Background and Objective: Life style with Low activity and overweight increased the risk of cardiovascular diseases. This study was done to evaluate the effect of ginger supplementation on Lactate dehydrogenase (LDH) changes and delayed muscle soreness following exhaustive eccentric exercise on overweight girls.
Methods: In this randomized clinical trial study, 22 overweight girls were randomly divided into the two groups including intervention (n=12) and control (n=10) groups. For subjects in interventional group were used a daily supplement of 2 grams of ginger powder, each serving a capsule, containing one gram of ginger powder  and subjects in control group were received  daily two capsules containing starch, for two weeks. Physical activity was performed consisting of two sessions of exhausting activity (negative tilt on treadmill, one session before supplementation and one session after two weeks of supplementation). Blood samples were measured in order to measure changes in LDH in four stages and the use of the pain questionnaire for evaluation of delayed muscular brittleness in both pre and post gingival supplementation. Pain scale (visual analogue scale: VAS) was used to measure the delay fatigue.
Results: The results showed that extrinsic exercise increased LDH and delayed muscle soreness after exercise (P<0.05). Also, taking two weeks of ginger supplementation significantly reduced LDH and delayed muscle soreness in the supplement group in comparison with controls (P<0.05).
Conclusion: Ginger can reduces the muscle gain and delayed onset muscle soreness resulting from eccentric exercise in overweight girls.

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Background and Objective: Creatine is one of the most important and commonly used supplements athletes, although the molecular mechanisms of creatine and its side effects are less understood. The high level of the ceratin kinase enzyme and lactate dehydrogenase enzymes are considered to be a sign of cell damage. This study was done to determine the effect of creatine monohydrate supplementation on creatine kinase (CK) and lactate dehydrogenase (LDH) enzymes following a severe muscle contraction in female athletes.
Methods: In this double-blind clinical trial study, 30 female athletes were randomly divided into intervention (creatine supplementation 0.3 grams per body weight for 4 times duing 7 days and control (placebo, starch powder) groups. Blood sample was collected before supplementation (pre-test) and 24 hours after Cunningham exercise test (post-test) to measuring CK and LDH in each subject.
Results: After intervention, the level of CK (323±63 IU/L) and LDH (119±13 IU/L) in intervention group had no significant difference in compared to control group (CK: 328±44 IU/L and LDH: 122±14 IU/L).
Conclusion: The usage of a 7-day course of creatine supplement did not significantly change the CK and LDH levels following a severe muscle contraction in female athletes.

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Background and Objective: Coronavirus disease 2019 (COVID-19) can lead to organ failure by the occurrence of mechanisms such as increased thrombosis and, subsequently, increased lactate dehydrogenase (LDH). This study was conducted to determine LDH serum levels in COVID-19 patients and the factors affecting their mortality.
Methods: This descriptive-analytical study was conducted on 212 patients (57 males and 155 females) with COVID-19 with a mean age of 49.19±10.6 referring to Imam Ali Hospital in Chabahar, Iran during 2021. After obtaining patients’ informed consent and demographic information, the heparinized peripheral blood sample was taken from them. The LHD levels were determined using an autoanalyzer.
Results: Twenty-nine (13.67%) patients died. The mean LDH serum level of 29 deceased patients (708.420±96.25 U/L) was not statistically significant compared to survivors (640.360±96.80 U/L in 183). The comparison between the surviving and deceased groups showed that 25% of the deceased patients were hospitalized in the intensive care unit (ICU), and 90.90% of the survivors were hospitalized in the internal ward (P<0.05). All the deceased and 85.85% of the survivors were 40 years old and above, and this difference was not statistically significant. Furthermore, 24.56% of the deceased were male, 90.32% of the survivors were female (P<0.05), 22.72% of the deceased had a university education, and 88.69% of the survivors had a diploma or under-diploma education (P<0.05), and 71.42% of the deceased patients had thin, and 91.37% of the survivors were overweight (P<0.05).
Conclusion: There was no difference in the LDH serum levels of the COVID-19 survivors and deceased. The age of 40 years and above, lean and morbidly obese body mass indices, male gender, and the need for hospitalization in the ICU were determined as risk factors.