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Kawasaki disease is a systemic vasculitis of unknown etiology. The most significant sequela of acute Kawasaki disease are related to information of small to medium sized arteries and, in particular, the development of coronary artery dilation and aneurysms (CAA). The aim of this study was to assess the cardiovascular complications of Kawasaki disease in Iran. The studied population consisted of 54 patients who were diagnosed to have Kawasaki disease and referred for cardiac evaluation. There were 30 boys and 24 girls, aged between 5 months and 13 years (Mean 3.9 years). All patients except 3 had received standard treatment with high-dose Aspirin and intravenous ? Globulin (IVGG). All patients were evaluated by physical exam, chest X-ray, ECG and echocardiography (ECHO). Abnormal cardiac findings included: Cardiomegaly in 4 (7.6%), ECG changes in 4 (7.6%), Mitral regurgitation in 3 (5.5%) LV dysfunction in 2 (3.7%), pericardial effusion in 4 (7.6%) and coronary artery dilatation in 5 (9.2%). Conclusion: 1) Kawasaki disease and its cardiovascular complications are not uncommon in Iran. 2) Coronary artery involvement is a major problem. 3) IVGG therapy reduces the risk of cardiac complications. 4) ECHO is a valuable tool in acute phase and follow-up period.

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Background and Objective: Kawasaki disease is the common acquired heart disease in children. Kawasaki disease is a vasculitis that predominantly affects the medium-sized arteries, with a striking predilection for the coronary arteries. This study was done to determine the relationship between coronary aneurysm formation and neutrophylia, in childern with Kawasaki disease. Method: This descriptive – analytic study was done on 80 children (45 Males, 35 Females) with typic and atypical Kawasaki disease in Afzalipoor hospital, Kerman, Iran during 2011-13. According to transthoracic echocardiography, patients were divided into childern with and without coronary aneurysm. CBC count, ESR and Peripheral blood smear was performed for each subject. Results: White blood cells, neutrophils, platlets and ESR in childern with coronary aneurysm, was non- significantly more than without aneurysm. Duration of fever in chidern without aneurysm was non-significantly more than childern with coronary aneurysm. Conclusion: Neutrophils counting by itself is not sufficient critria for the prediction of the aneurysm risk in kawazaki disease.

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Kawasaki disease is a medium-size vasculitis with peak incidence among infants of 9 to 11 month age. This case report represents a female infant of 18-month age whom was admitted to the Taleghani Pediatric Center of Gorgan, Iran; with referral for admission due to persistent fever for roughly 2 weeks despite various outpatient treatments. Upon the admission, Echocardiographic study was performed to assess whether the patient fulfils cardiac criteria of Kawaski disease which was consistent with the diagnosis and also positive for serious coronary complications in the infant. General condition of the patient improved as the treatment with both IVIG and Corticosteroids was initiated and carditis seemed to vanish in echocardiographic studies but as expected aneurysmal growth can last for over 80 days and in this case serial echocardiographic studies confirmed the formation of giant coronary aneurysms. Diagnosis of Kawasaki disease is based on persistent fever and consistency with clinical criteria and the main purpose of this case report was to emphasize the need to consider this disease in cases of persistent fever to avoid the serious following complications.