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Showing 3 results for Inflammatory Bowel Disease
Amiriani T, Besharat S, Semnani Sh, Joshaghani Hr, Roshandel Ghr, Keshtkar Aa, Kiaii Mr, Mirkarimi Hs, Hashemi-Nasab Sz, Zendeh-Bad As,
Volume 13, Issue 1 (3-2011)
Abstract
Background and Objective: Celiac is a hereditary disease presented with chronic inflammation of small intestine. Several studies supposed a relationship between Celiac disease and Inflammatory Bowel Disease (IBD). Tissue trans-glutaminase antibody is one of the best serological markers in Celiac disease. This study was designed to evaluate the association of Celiac and IBD using tissue trans-glutaminase antibody.
Materials and Methods: In this descriptive study 127 confirmed IBD patients who were referred by gastroentrologists 2005-08 enrolled into the study. A questionnaire was completed and tissue trans-glutaminase antibody was evaluated with ELISA method with a Cut-off=12 U/ml.
Results: Among 127 referred patients, serum samples of 102 patients were collected. Mean±SD of age was 36.17±15.2 years and 48% were males. Ulcerative colitis, Crohn’s disease and other colitis were observed in 76 (74.5%), 7 (6.9%) and 19 (18.6%) of patients, respectively. Tissue trans-glutaminase antibody was positive (19.8 U/L) in one 46-years-old male patient with ulcerative colitis.
Conclusion: Tissue trans-glutaminase antibody titer was not significantly different between IBD patients and controls, thus it seems not appropriate to suggest as one of the routine tests in IBD patients.
Mozafari Chenijani Sn, Azarhoush R, Amiriani T, Roshandel Ghr,
Volume 16, Issue 2 (7-2014)
Abstract
Background and Objective: Colonoscopy is the best method for management of patients with Hematochezia or lower gastrointestinal bleeding (LGIB). This study was conducted to assess the endoscopic and histopathologic findings in patients with hematochezia. Methods: This descriptive –analytical study was done on 117 (50 males, 67 females) patients whom referred to 5th Azar hospital in Gorgan, northern Iran during 2010. Demographic characteristics, medical history and colonoscopic and histopathologic findings were recorded for each patient. Results: Hemorrhoid was the most common finding in colonoscopic examination. Inflammatory bowel disease (IBD) and cancer were the most common feature in the under and higher than 43 age old patients, respectively (P<0.05). Ulcerative colitis (22.2%) was the most common finding in histopathological examination. Rectosigmoid was the most common anatomical location of involvement in IBD cases. Cancer and IBD were occurred in the left colon. Conclusion: Flexible sigmoidoscopy can be a selected procedure for evaluation of hematochezia in the <43 age old patients but in >43 age old subjects sigmoidoscopy or colonoscopy should be made based on patients' status.
Leila Kashani , Firoozeh Derakhshanpour , Mahsa Eliasi , Najmeh Shahini , Seiedeh Maryam Hasheminasab ,
Volume 24, Issue 1 (3-2022)
Abstract
Background and Objective: Inflammatory bowel disease (IBD) is a common gastrointestinal disease which is associated with psychosocial factors. IBD is a gastrointestinal disease with chronic recurrence and with an uncontrolled immune response. There is no definitive treatment for IBD and treatment is based on management of inflammatory response during relapse and maintain of recovery. This study was conducted for evaluation of anxiety and depression disorders in patients with IBD in Golestan province, north of Iran during 2017.
Methods: In this descriptive-analytical study, 117 patients (67 women and 50 men) aged 17-75 years with IBD registered in IBD bank in Golestan Research Center of Gastroenterology& Hepatology (GRCGH), north of Iran during 2017. Diagnosis was made by conventional endoscopy, radiology and histological criteria. Demographic information including age, sex, race and marital status, time of diagnosis until now and duration of treatment are recorded. Hospital anxiety and depression scale (HADS) were used for determine depression and anxiety in these patients.
Results: 80.3% ulcerative colitis and 19.7% Crohn's disease was observed in patients. The mean of total anxiety score in the group with Crohn's disease was higher than ulcerative colitis but there was no significant difference. Total score of depression was similar and not significant in both groups. There was a significant statistical relationship between marital status and anxiety in patients with ulcerative colitis only (P<0.05). As borderline and suspicious status of the patient in married patients is 42.4% and in single patients is 33.3%. Abnormal anxiety state was 31.8% in married patients and not seen in single patients. A positive and significant correlation was seen between total anxiety scale and total depression scale in patients with ulcerative colitis (correlation index: 0.657, P<0.0001) and in patients with Crohn's disease (correlation index: 0.644, P<0.001). Therefore in these patients, if depression increases, anxiety was also increasd. Anxiety observed in 29.8% and 26.1% of ulcerative colitis and Crohn's disease, respectively. Depression disorders observed in 18.1% and 8.7% of ulcerative colitis and Crohn's disease, respectively.
Conclusion: This study showed that the level of anxiety and depression in patients with inflammatory disease is very high.
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