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Background&Objective: Burning and burn wound are the causes of mortality in the world. The present study was designed to investigate the effect of egg yolk (of hen) on burn wound healing in Rats. Materials&Methods: In this experimental sutdy, 48 females rats randomely divided in silver sulphadiazin, egg yolk and control groups, respectively. Each of three groups including 16 rats and was selected for 28 days of treatment. After general anesthesia with ketamin and xylazin (ip) an area of the back of rats was burned with red-hot coin and similar grade II burns were created. Control group received no medication. In the second and third groups, the surface of wound was covered daily with sulphadiazine and egg yolk. At the end of the eack week, four rats from the each group were scarified by ether and samples were taken from the wound region and were histologically assessed. The samples were stanied with Hematoxillin and Eosin and studied quantitively. Results: Results showed that after 4 weeks the healing of burn wounds in the groups receiving egg yolk and sulphadiazine were similar. But healing of burn wounds within these 2 groups was better than control group. There was no difference between the groups receiving either egg yolk or sulphadiazin. Conclusion: This study showed that egg yolk can be used as an alternative to sulphadiazin in second degree burn wounds.

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Background & Objective: On the bases of the antiinflammatory, antimicrobial and antioxidant effects of matricaria chamomilla (chamomile) extract. This study was design to determine the effect of topical hydroalcoholic chamomile extract on burn wound healing in albino Rats. Materials & Methods: In this experimental study 30 male albino Rats were randomly divided into 3 equal groups, as sham, control (olive oil) and treatment. Second degree burning was induced in 20% of whole surface area of animal body by diving the back of animal into boiling water for 8 seconds. Animals of control group received no treatment. Animals of olive oil and treatment groups were treated topically by olive oil and hydroalcoholic extract dissolved in olive oil twice a day respectively from the first day of burn induction to complete wound healing. Results: The results showed that there was not significant difference between olive oil and sham groups in all days of experiments. Also there was significant difference in wound healing (p<0.05) between olive oil and treatment groups (62.96±2.70 versus 74.77±2.50) from the day of 20 to the end of experiments. Conclusion: This study showed that the hydroalcoholic chamomile extract has a treatment effect on burn wound healing in animal model.

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Background and Objective: Aloe barbadensis Miller plant was used for treatment of wound healing in traditional medicine. However it has different and sometimes contradictory effects. In this study the effect of Aloe barbadensis Miller gel on skin incisional wound healing in Rat was investigated. Materials and Methods: In this experimental study, forty male wistar Rats were randomly divided into 4 experimental groups including: sham operated, control and two treatment groups. Under deep anesthesia, an incision (3cm, full thickness) was made over skin of the back in Rats. The animals of sham group received no treatment. Control group received topical cold cream twice per day (from beginning to end of experiment) and treatment groups' similarliy received topical Aloe barbadensis Miller gel mixed with cold cream (25% and 75%). For computing the percent of wound healing, the area of wound measured at the days 2, 4, 6, 8, 10, 12, 14 and 16 after beginning of experiments. Results: Aloe barbadensis Miller gel at concentration 25% and 75% significantly improved wound healing at 12th day and 8, 10 and 12th days, respectively in comparison with control group. Conclusion: This study indicated that local administration of Aloe barbadensis Miller gel, accelerate the skin incisional wound healing in Rat. This healing is related to the gel concentration.

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Background and Objective: Onosma dichroanthum Boiss. is one of the most important mountainous medicinal plants in Iran. This study was done to determine the biomechanical evaluation of root extract ointment of Onosma dichroanthum Boiss. on wound healing in rats. Materials and Methods: In this experimental study, 18 male adult Wistar rats were randomly allocated into control (I), vehicle (II) and treated group with ointment containing of extract 1% of root of Onosma dichroanthum Boiss., (III). 20 mm vertical skin incision wound were made on rats back side. The assessment of the wound healing was carried out at day 14. At the end of study, rats were sacrificed, skin sample were extracted and evaluated by biomechanical method (maximum force, elastic stiffness, energy absorption). Results: There was no significant difference in biomechanical parameters among the treated, vehicle and control groups. Conclusion: Topical application of Onosma dichroanthum Boiss. root have no effect on healing of skin wound in animal model.

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Background and Objective: Diabetic mellitus is one of the main health problems of diabetic subjects skin wound. This study was done to evaluate the effect of topical ointment produced from aqueous extract of grape seed (Vitis Vinifera) plus Eucerin on wound healing in diabetic rats.

Methods: In this experimental study, 48 male Wistar rats were randomly allocated into control, first, second and third experimental groups. Animals in control group were received only buffer citrate, interaperitonally. Diabetes was induced by 55 mg/kg/bw of Streptozotocin in three experimental groups. Skin wound (2´3 cm²) was created in left side of the lumbar region in three experimental groups. Animals in experimental gourp 1 did not received any treatment. The wounds of animals in experimental group 2 were treated with topical ointment of Eucerin twice a day. The wounds of animals in experimental group 3 were treated with topical ointment of aqueous extract of grape seed plus Eucerin with a ratio of 3:1 for 21 days twice a day. Wound healing process was evaluated using macroscopic and histological method.

Results: The mean area and percentage of wound after treatment was significantly reduced in experimental group 2 and 3 in compare to experimental group 1 (P<0.05). The percentage of improvement wound healing was significantly increased in experimental groups 2 and 3 in compare to experimental group 1 (P<0.05). Synthesis of collagen fibers was increased in experimental group 3 in compare to experimental group 2 and 1.

Conclusion: Topical application of aqueous extract of grape seed with ointment of Eucerin accelerates skin wound healing in diabetic rats.

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Burn is one of the major causes of death and disability in the world. It can cause by heat, chemicals, electricity, sunlight or radiation. More burns caused by fires in buildings, contact with boiling water, steam, liquids and flammable gases. Accelerating the process of healing has always been of interest to practitioners because these injuries are usually takes long time to be healed. Therefore, proper treatment and care of this type of wound required to accelerate healing, prevent infection and chronicity. In traditional medicine, due to the high vegetation diversity and breadth of our country, the use of herbs for burns healing and lesions of various etiologies, has been intesified. Various studies on burn wound healing properties of medicinal plants have been performed. In this article, we refered to reliable sites for evaluating of 10 plants including Amebia euchroma, Green Tea, Hypericum perforatum, Centella asiatica, Scrophularia striata, Aloe vera, Cydonia Oblongae seeed, Malva sylvestris, Calendula officinalis and Myrtus to compare the restorative properties of a number of important medicinal plant flora of Iran on accelerating the process of wounds healing of burn in order to provide effective medicinal plant sources are addressed.

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Background and Objective: Burn is one of the leading causes of mortality in the world. This study was done to determine the effect of the lavender, sesame oil, and combination of Lavender with sesame oil and silver sulfadiazine on the burn wound healing in mice.
Methods: In this experimental study, 30 male adult albino mice were randomly allocated into 5 groups as follows: the negative control group (physiology serum); the positive control group (silver sulfadiazine); the first experimental group (sesame oil), the second experimental group (combination of Lavender with sesame oil) and the third experimental group (Lavender oil).Second degree of  burn wound healing  take place using hot sheet with a diameter of 2 cm. wound treatment was done in five groups in 21-day treatment period. The wound diameter size and restoration percentage were measured on days 1, 3, 6, 9, 18, and 21. Some mice were euthanized and the samples of wounds were used for histopathological studies.
Results: The percentage of wound healing significantly increased in groups of silver sulfadiazine, combination of Lavender with sesame oil, Lavender oil and  sesame oil in compared to control group (P<0.05). The improvement percentage was seen in sulfadiazine and combination of Lavender with sesame oil groups in compared to negative control group. The level of tissue restoration based on the accumulation of collagen, fibroblasts, re-epithelialization were seen in sulfadiazine, combination of Lavender with sesame oil, Lavender oil and sesame oil, respectively.
Conclusion: Combination of Lavender with sesame oil similar to silver sulfadiazine has tissue restoration effect on burn wound healing in animal model.

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Background and Objective: Type 2 diabetes is a common disease that could be prevented or managed with a healthy lifestyle. This study was conducted to determine the effects of self-healing with mindfulness-integrated cognitive behavior therapy on the health-promoting lifestyle profile of patients with type 2 diabetes.
Methods: This clinical trial was done on 45 patients with type 2 diabetes who had been referred to the Sedigeh Tahereh Clinic in Isfahan (Iran) in 2021. The patients were randomly divided into 3 groups of 15 patients: a control group, a self-healing group (first intervention) and a mindfulness-integrated cognitive behavior therapy group (second intervention). Interventions for each treatment were held as a weekly 90-minute online session. Posttest was After 12 sessions and three months after the test was followed up. The research tool was a health-promoting lifestyle profile questionnaire with nutrition, exercise, health responsibility, stress management, interpersonal support and self-fulfillment components. The questionnaire was filled out by each group after the 12 sessions and three months after the last session.
Results: Both the self-healing methods and the mindfulness-integrated cognitive behavior therapy increased the lifestyle scores of patients with type 2 diabetes compared to the control group (P<0.05), and the effect was maintained in both intervention groups in the follow-up phase. No difference was observed between the two treatment methods compared with the control group.
Conclusion: Self-healing and mindfulness-integrated cognitive behavior therapy is both effective in improving the health-promoting lifestyle profile of patients with type 2 diabetes.