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Background&Objective: Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the seroepidemiology celiac disease in this area with high prevalency of esophagus cancer. Materials&Methods: This research was a descriptive study, which was performed on blood donors in Golestan province during the year 2005-06. blood samples were taken from 2547 subjects. tTG-IgA determination were carried out using ElISA technique, the titre<4U/ml, 4-10U/ml and >10Um/l were considered to be as negative, weakly positive and positive respectively. EMA antibody assessment were carried out on all sample population with more than 4U/ml, using IFA method. Results: 28 subjects (1.1%) had tTG-Ab positive test, out of this number 18 subjects (0.7%) were weakly positive and 10 persons (0.4%) were considered to be positive. EMA test were positive in 70% of subjects with tTG positive results. There was not any significant meaning between positive tTG test and ethnicity from weakly positive tTG, 15 subjects (83.3%) and 3 subjects (16.7%) were male and female respectively. The entire tTG positive were male subjects. Conclusion: In regard to high prevalency of esophagus cancer in the region and the relation of celiac disease with above cancer, it seems necessary to look more seriously at the celiac disease.

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Background&Objective: Cancer of the esophagus ranks among the 10 most frequent cancers in the world. As esophagus cancer belt is coincide with loess deposits belt of the world, So there is possibility of close relationship between loess deposits and certain endemic diseases such as esophagus Cancer. This study deals with Loess deposits with medical geology aspect toward diagnosis and prognosis. Materials&Methods: In this study sampling from loess deposits from East towards West of Golestan province has been done. Collected samples have been undergone diffraction X-ray (XRD), scanning electron microscopy (SEM) and Energy dispersive X-ray analysis (EDAX) for determination of minerals, Surface morphology of minerals and chemical analysis for further studies respectively. Results: In mineralogical studies dominated minerals are quartz, feldspar and calcite. Clay minerals are illite and chlorite, which are about 9.3%. The amount of quartz is variable from 56.3 to 45.4. The grains sizes are decreasing from northeast to southwest. Chemical analysis of loess deposits contain Si, Al, K and Ca, which are related to presence of quartz, feldspar, calcite, illite and chlorite minerals. Conclusion: According to medical geology evidences, loess deposits of Golestan province could be considered due to the effects of clay minerals on biochemical cycle, chemical composition of loess deposit for its high silica percentage and direct relationship of grain size with ethiology of esophagus cancer incidence. As variation of esophagus cancer incidence in Golestan province in last 30 years indicates that still high percentage of esophagus cancer incidence which is reported in eastern of province is occurred on loess deposits.