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Background and Objective: The compound of MDMA or 3,4methyl deoxy met amphetamine, so called ecstasy, is a new narcotice compound. Ecstasy tablets have a temporary exciting and deteriorating side effects. This study was done to determine the knowledge and attitude of University students about ecstasy tablets in Gorgan, Iran. Materials and Methods: This descriptive - analytic study was done on 300 university students in Gorgan during 2006. The tools of data collection were questionnaire. This questionnaire developed by authors, consists of demographic, knowledge and attitude questions respectively. The data were analized by SPSS software and Kruskal- Wallis and Mann- Whitney tests. Results: 3% of subjects had previous usage of ecstasy. The 27.3% of students had poor knowledge about ecstasy, also 52.3% and 12.7% of students had middle and high knowledge about ecstasy respectivly. There was significant relation between knowledge and attitude with educational level, family income, parents occupation and previous usage of ecstasy (P<0.05). But there was not any relation between knowledge and attitude and age, gender, and filed of education and source of information enquiry. There was a possitive correlation between knowledge and attitude of students (P<0.001, r=0.243). Conclusion: This study showed that knowledge and attitude of University students about ecstasy is low. Therefore educational programs about ecstasy is nessecery to increase the knowledge and attitude of university students.

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Background and Objective: The pregnancy period is very sensitive and complicative stages of life. It has been shown that addictive drugs such as ecstasy (MDMA: Methylene Dioxy Metha Amphetamine) can interfere in this stage. The aim of this study was to assess the effect of Methylene Dioxy Metha Amphetamine administration during pregnancy on reproductive system of BALB/c mice. Materials and Methods: In this experimental study, 10 and 5 female BALB/c mice were randomly selected as cases and controls, respectively. The pregnancy was induced following ovarian hyperstimulation with PMSG and hCG followed by mating with male animals. MDMA (5 mg/kg) and saline was injected intraperitoneally in day 7 and 14 of pregnancy in experimental and controls, respectively. The ovarian structure, as well as uterine tube, uterine horns and body, and vagina were studied histologically using light microscopy 27 days post delivery date. Data analyzed by using SPSS-17 and Chi-Square and Fisher exact test. Results: The rate of primary follicles was decreased from 18.42% in experimental to 33.33% in controls (P<0.05). The rate of mature follicles was significantly increased in experimental mice as compared to controls (P<0.05). The number of atretic bodies was lower in experimental than controls. The cellular alterations were observed in some portions of uterine tubes and uterine horns after ecstasy administration. However, no alterations observed in other parts of reproductive system. Conclusion: This study showed that MDMA cause some structural alterations in the uterine tubes and uterine horns, increase follicular maturation and reduction of follicular atresia in BALB/c mice.