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Background and Objective: Physical activities affect on antioxidative pathway. Varity, period and intensity of activities are important in health improvement. This study was carried out to determine the effect of short and medium periods of high intensities aerobic training on serum level of superoxide dismutase (SOD) and Catalase (CAT) enzymes in female rats. Methods: In this experimental study, 45 Sprague Dawley female rats were randomly allocated into control, short (4 weeks) and medium (8 weeks) of high intensities aerobic training groups. The exercise program was performed on 5 session in each week with speed of 10-17 meters per minute in slope range (5

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Catalase is the one of the most important antioxidant enzymes that is found abundantly in liver and kidney. The alteration in activity and function this latter enzyme are widely investigated in various types of cancer to understand the cancer mechanism and its treatment. The changes in the catalase activity levels in a variety of cancer cells is as a specific property of tumor tissues due to the reducting catalase activity at mRNA level. In this review, various reports that examined the alterations in catalase activity and resistance to chemotherapy and its complications in the literature are summarized and discussed. Due to the important role of hydrogen peroxide in various stages of cancer process, catalase alters this process by detoxification of hydrogen peroxide. Chemotherapy increase free radicals to destroy the tumor cells, then, catalase activity reduced their impact on cancer cells. On the other hand, it might be concluded that production of drug resistance in chemotherapy is resulted due to increasing catalase activity. Therefor it seems catalase has contradictory influence on the treatment and development of cancer.

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Background and Objective: Different physical activities affect on anti-oxidative system. Varity, period and intensity of activities are necessary in health improvement. This study was carried out to determine the effect of medium period of progressive anaerobic training on serum level of superoxide dismutase and Catalase in female rats.

Methods: In this experimental study, 30 female rats were randomly allocated into control and anaerobic training groups. The training program lasted for 8 weeks with control (without activity) and anaerobic including 3 sessions in a week with speed of 24-30 meters per minute in slope range (515) for 30 seconds.

Results: Serum level of superoxide dismutase was significantly increased in progressive anaerobic training group (109.1±17.3 U/ml) in compare to controls (98.8±12.8 U/ml) (P<0.05). Serum level of Catalase was 51.2±7.2 and 48.4±4.2 U/ml in control and progressive anaerobic training, respectively. This difference was not significant.

Conclusion: The medium period of progressive anaerobic training influences serum level of superoxide dismutase and Catalase in female rats.

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Background and Objective: Multiple sclerosis (MS) is a common neurological disease that increases oxidative stress and causes immune system disorders. Curcumin is the active component of turmeric with anti-inflammatory properties. This study was conducted to determine the effects of curcumin on cortisol, catalase, and nerve growth factor (NGF) expression in an animal model of MS.
Methods: This experimental study was conducted on 30 female Wistar rats. Experimental autoimmune encephalomyelitis (EAE) was chosen as an experimental model of MS. The rats were divided into 3 groups of 10, including a healthy control group, an affected group, and a group treated with curcumin. The disease was induced by immunization of rats with homogenized guinea pig spinal cord and Freund's complete adjuvant. Then, the immunized animals were allocated into two equal groups. Treatment with curcumin (100 mg/kg daily) was started 12 days after the immunization when the rats showed the first symptoms of neurologic disability. The treatment was continued until day 24 post-immunization. Simultaneously, the EAE group received the medicine solvent (distilled water). Finally, the rats' weights as well as cortisol, catalase, and NGF levels were measured in the study groups.
Results: Curcumin significantly increased the level of cortisol to a level equal to that of healthy rats (P<0.05). It also significantly increased the expression of NGF and reduced the amount of catalase in the affected rats (P<0.05). The curcumin administration significantly increased the overall weight of rats with MS but had no significant effect on the spleen weight of the treated rats.
Conclusion: Curcumin can be beneficial for treating EAE by reducing the destructive effects of oxidative damage and increasing NGF.