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Background & Objective: Cardiovascular disease is among important factors of mortality in hemodialysis patients. There are some reports that indicate the Carnitine concentration reduction in the tissues accelerate cardiovascular abnormalities in those patients whom regularly are hemodialysed. This research has been set up to study the effect of oral Carnitine on the heart function of hemodialysis patients from Sari and Vali-Asr Hospital in Ghaem-Shahr Fatemeh Alzahra, Imam Khomeini in during 2003. Materials & Methods: In this study 20 patients with at least 3 month duration and 3 times interval hemodialysis in each month were chosen. The sample hemogenously devided in case and control group. One Carnitine tablet with 1 gr dose was given to the case group daily. The placebo was prescribed to the control group EF and LVEDD of patients were determined by echocardiography. The ratio diameter of heart to the chest was determined by chest radiography. The plasma level of hemoglobin, Cholesterol and Triglyceride were determined simultaneously. Results: There was not any meaningful recovery in EF and LVEDD and serum Lipids, between the case and control group 6 months after treatment with 1 gr/day Carnitine. There was only a meaningful difference in EF after 6 months duration of this study. In spite of this, there was a meaningful recovery with these patients anemia (P?0.05). Conclusion: Carnitine does not have a meaningful effect of heart function and serum Lipid level, but it has an efficacy on anemia recovery of such patients.

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Background and Objective: Several studies reported the contraventional effects of L-Carnitine on body fat percentages and lipoprotein profile. This study was done to evaluate the effect of six weeks supplementation of L-Carnitine on body fat percentages and lipoprotein profile non-athlete male students. Methods: This quasi-experimental study was conducted on 20 non-athlete male students whom were non-randomly assigned into experimental and control groups. Subjects in both groups performed aerobic exercises for six weeks based on the principle of overload. Over the course of this period, subjects in the experimental group were received 13 mg/kg/bw of complement g L-Carnitine, orally. Controls were received 3 mg/ke/g/bw of starch on daily bases. Blood samples were collected before and after the training period. HDL, LDL-c, VLDL, triglycerides, total cholesterol, body fat percentage and body mass index were recorded for each subject. Results: Aerobic exercise with supplementation of L-Carnitine significantly increased HDL and reduced triglycerides, total cholesterol, body fat percentage and VLDL, but had no significant impact on LDL-c and body mass index. Conclusion: Consumption of slight doses of L-Carnitine in combination with aerobic exercise reduces body fat percentage and lipoprotein profile of non-athlete male students

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Background and Objective: Obesity by releasing inflammation factors such as Interleukin-6 (IL-6) cause atherosclerosis and cardiovascular diseases. Also, L-carnitine reduces inflammatory factor such as IL-6. The study was done to determine the effect of eight week endurance training with L-carnitine supplementation on IL-6, nitric oxide (NO), blood pressure, and body composition in young obese women.
Methods: In this clinical trial study, 40 volunteer young obese women (age: 23.3±2.3 yrs. and BMI: 31.1±1.4 kg/m²) randomly assigned in the endurance training with L-carnitine (ETL; n=10), endurance training with placebo (ETP; n=10), L-carnitine supplementation (LCS; n=10) and control (Con; n=10). The training protocol consisted of endurance training with gradually increasing of duration and intensity (25-min at 50% HR max and increased to 45-min at 70% HR max), three session a week for 8 weeks. The supplement groups consumed 3gr of L-carnitine daily, while the placebo group ingested the same amount of maltodextrin. Blood pressure and blood samples were obtained before and 36 hours after training protocol, and serum levels of IL-6 and NO were measured by ELISA method.
Results: IL-6, weight, fat mass and fatty percent was significantly reduced in ETL and ETP groups compared to control and LCS groups (P<0.05), and this reduction was lower in the ELT than ETP group (P<0.05). Also, NO was significantly increased in the ELT and ETP groups compared to the LCS and controls (P<0.05).
Conclusion: Although the implementation of endurance training with and without L-carnitine for 8 weeks caused to decrease of IL-6, increase of NO and improved body composition, but the effect of endurance training with L-carnitine on decreasing of IL-6, weight and fat mass was significantly better.