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Showing 2 results for Alanine Transaminase
Mandana Salehi , Kahin Shahanipour , Ramesh Monajemi , Parisa Mohamadynejad ,
Volume 24, Issue 2 (7-2022)
Abstract
Background and Objective: Many studies have been done on the effects of ginseng and green tea on inflammatory factors and liver enzymes, but no research has yet studied the comparative effects of ginseng and green tea extracts with Pomeol Breuler on C-reactive protein (CRP) and liver enzymes in hyperlipidemic rats. This study was done to evaluate the effects of ginseng and green tea extracts in comparison with Pomeol Bruler on CRP and liver enzymes in hyperlipidemic rats.
Methods: In this experimental study, 42 male Wistar rats were randomly allocated into 7 groups. Animals in group 1 (control group) received a normal diet. The experimental groups 2-7 received a high-fat diet for a month. The groups were treated with the extract for 8 weeks and by intraperitoneal injection. Groups 1 and 2 received 77.5 mg/kg/day and 155 mg/kg/day green tea extract, respectively. Groups 3 and 4 received 103.3 mg/kg/day and 206.6 mg/kg/day ginseng extract, respectively. Group 5 received 0.16 g/kg/day of Pomeol Bruler, and group 6 received green tea extract (155 mg/kg/day) and ginseng extract (206.6 mg/kg/day). At the end of the treatment, the level of CRP and liver enzymes including aspartate transaminase (AST) and alanine transaminase (ALT) were measured.
Results: The level of CRP was significantly reduced in the rats treated with ginseng, green tea, and Pomeol Bruler compared with the control group (P<0.05). The level of AST and ALT did not differ significantly between the ginseng, green tea, Pomeol Bruler, and control groups.
Conclusion: The combined use of ginseng and green tea with Pomeol Breuler for 8 weeks may reduce inflammatory factors but does not affect liver enzymes.
Vakil Nadimi , Shohreh Taziki , Fatemeh Kolangi , Mohammad Mazandarani , Zahra Memariani ,
Volume 24, Issue 3 (10-2022)
Abstract
Background and Objective: The liver is the main organ involved in the metabolism of various drugs and toxins. Thus, it is highly vulnerable to damage caused by drugs and toxins. Alpinia officinarum belongs to the Ginger family and has been used in traditional Iranian medicine for its therapeutic effects on the digestive system, including strengthening the function of the stomach and organs, improving digestion and reducing bloating. In addition, the plant has anti-hyperlipidemic, anti-inflammatory, antiviral, antibacterial, anticancer and antioxidant properties. This study investigated the hepatotoxic effects of Alpinia officinarum rhizomes aqueous extract in male Wistar rats.
Methods: This experimental study was performed on 35 male Wistar rats that were randomly allocated into 5 groups of 7. Four groups received 100, 200, 400 and 800 mg/kg of the extract for 28 days, while a group did not receive the extract (control group). Tissue sections (5 microns) were stained by hematoxylin and eosin at the pharmacology laboratory of Golestan University of Medical Sciences. The groups were examined for liver tissue pathology, and the level of liver enzymes including aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) was measured by Pars Azmoun ELISA kit.
Results: Administration of the aqueous extract of Alpinia officinarum rhizome for 28 days by gavage increased the level of AST, ALT and ALP in the serum of rats. Tissue damage was observed in most groups receiving the extract.
Conclusion: The results show that consumption of the aqueous extract of Alpinia officinarum rhizome at a dose of more than 100 mg/kg can cause liver damage and is lethal at a dose of 800 mg/kg.
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