Background and Objective: Lead threaten living creature’s life as air pollutant and causes several diseases such as degenerative disease of nervous system. This research was conducted to determine the effect of Curcumin on BDNF changes and oxidative/antioxidative process in rat’s hippocampus which exposed to Lead acetate.

Materials and Methods: In this experimental study, 40 male Wistar rats were randomly assigned to four groups of ten: Base, Sham(control), lead and Curcumin+Lead. lead and Curcumin+Lead groups received 20 mg/kg lead acetate and Curcumin+Lead group also received 30 mg/kg Curcumin, peritoneally for 8 weeks (3 days in weeks). MDA (oxidative stress biomarker) and TAC (total antioxidative capacity) levels were measured by TBARS and FRAP methods, respectively, and hippocampus BDNF level was measured by ELISA method in rat hippocampus region. Data was analyzed by one-way ANOVA test and Tukey at P<0.05 level.

Results: Injection of lead acetate significantly increased MDA, non-significantly decreased hippocampus BDNF and significantly decreased TAC levels in the Lead group compared with control groups. On the other hand, curcumin administration led to non significantly decreased MDA, nonsignificantly increased BDNF and significantly increased TAC levels compared with other groups (P<0.05).

Conclusion: This study showed that Curcumin adminstration in long term lead acetate-treated male Wistar Rats did not increased BDNF of hippocampus, but it prevent the reduction of BNDF due to lead-intoxification.

Sports activities are hindered by the lack of clean air in large and industrialized cities, and the countless benefits of exercise are not considered. With the search of the literature, 89094 articles related to air pollution that have been published in SID, PubMed, and Web of Science until December 2021 were found. Ultimately, 80 articles were extracted after selecting the articles and narrowing the search to exercise inflammation and lung tissue. After removing out-of-date articles (not published between 2000 and 2021) and those without full text, 65 articles were included in the review. Based on the review, exposure to air pollution is associated with increased inflammation and decreased cellular immune function, which is characterized by the activation of toll-like receptors and downstream signaling pathways. Regular exercise improves the inflammatory status in different pulmonary diseases. People who exercise in polluted environments are at increased risk of respiratory and cardiovascular diseases due to the elevated amount of pollutants delivered to the lungs. However, studies did not take into account the potential anti-inflammatory effects of exercise training, which could inhibit the pro-inflammatory events induced by air pollution. It seems that regular exercise modifies pulmonary inflammatory responses and body mass and in part decreases the risk of pulmonary diseases.