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Background and Objective: The quality of life is advesly affected by type 2 diabetes as a serious metabolic disorder. This study was done to investigate the effect of aerobic training and drug intervention on quality of life in women with type 2 diabetes. Materials and Methods: In this randomized clinical trial study, 52 women with type 2 diabetes divided into four groups including aerobic training with full medicinal doses (group I), aerobic training with half medicinal doses (group II), full medicinal doses without training (group III) and half medicinal doses without training (group IV). Subjects in aerobic training groups participated in 8 weeks training program. Duration of each training session was 45 minutes from the beginning and increased gradually until 105 minutes. Full medicinal doses included Metformin (500 mg) and Glibenclamide (5 mg). Half medicinal doses included Metformin (250 mg) and Glibenclamide (2.5 mg), daily. Subjects without training, did not participate in any physical activities. Quality of life was assessed using SF-36 questionnaire. Data were analyzed using SPSS-18, ANOVA and t dependent tests. Results: There was no significant difference regarding quality of life between groups at pre-test. After the intervention, the quality of life in group I significantly increased (P<0.05). In group II, all subscales of the quality of life increased however, only social function was significant (P<0.05). In group III, all subscales of the quality of life decreased however, physical function, emotional and pain were significant (P<0.05). In group IV, the quality of life significantly decreased (P<0.05). Conclusion: Aerobic training with full medicinal doses could improved the quality of life in women with type 2 Diabetes.

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Background and Objective: Oxidative damage associated with the presence of Lead in the brain has been proposed as one possible molecular mechanism involved in Lead toxicity. Aerobic exercise is known to protect the brain through a cascade of molecular and cellular processes. The purpose of this study was to investigate the effect of 8 week aerobic training on the brain-derived neurotrophic factor (BDNF) and malondialdehyde (MDA) levels in rat's cerebellum exposed to Lead acetate. Materials and Methods: In this experimental study, 40 Male Wistar rats were randomly allocated into four groups: sedentary base, sham (30 mg/kg of ethyloleate), Lead and exercise+Lead (20 mg/kg Lead acetate, intraperitoneally). The exercise program consisted of progressive running training on the treadmill for 15 to 22 m/min, 25 to 64 min/day, and 5 days/week for 8 weeks. BDNF and MDA levels were measured by ELISA and TBARS methods, respectively. Results: Chronic Lead acetate administration enhanced significantly (P<0.05) cerebellar MDA levels in rats compare to base and sham groups but had no effect on BDNF levels. Cerebellar MDA significantly was reduced and BDNF non significantly was increased in Lead acetate+ training group. Conclusion: Regular aerobic exercise with moderate intense may exert role neuroprotective against Lead-induced cerebellar injury by down-regulating oxidative stress and promotes brain health through increases in BDNF.

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Background and Objective: Physical activities affect on antioxidative pathway. Varity, period and intensity of activities are important in health improvement. This study was carried out to determine the effect of short and medium periods of high intensities aerobic training on serum level of superoxide dismutase (SOD) and Catalase (CAT) enzymes in female rats. Methods: In this experimental study, 45 Sprague Dawley female rats were randomly allocated into control, short (4 weeks) and medium (8 weeks) of high intensities aerobic training groups. The exercise program was performed on 5 session in each week with speed of 10-17 meters per minute in slope range (5

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Background and Objective: There are controversial reports about the effect of training on serum level of visfatin and TNF-α Cytokine .This study was done to evaluate the effect of 8 weeks of aerobic training on serum level of visfatin and TNF-α in non-athletic young women. Methods: In this quasi-experimental study, thirty non-athletic healthy women were non-randomly based on the weight, height, BMI index and body fat percentage divided into two control and training groups. In the training group 8 weeks of aerobic exercise on a stationary bicycle 3 times a week was performed. Serum level of visfatin and TNF-α was measured using ELISA method, prior and at the end of 8th week of training while the subjects were fasted for 12-14 hours. Results: At the end of 8 weeks of aerobic exercise, serum level of visfatin and TNF-α significantly reduced in the training group in comparison with controls (P<0.05). Conclusion: Eight weeks of aerobic training reduces visfatin and TNF-α serum level in non-athletic healthy women.

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Background and Objective: Leptin has a key role in obesity and type 2 of diabetes. This study was done to compare the effects of eight weeks aerobic and combined training on serum levels of leptin and glucose in type 2 diabetic men. Method: This clinical trial study was performed on 24 men with type 2 diabetes whom reffered to Taleghani Hospital in Kermanshah, West of Iran during June to August 2012. The patients were randomly divided into 3 groups including aerobic training, combined training (aerobic and resistance training) and control groups. Training protocols included three 1-hour sessions per week for eight weeks. Subjects in the control group did not participate in any physical activities. Serum levels of leptin and glucose were measured 48 hours before and 48 hours after intervention as fasting values in pre-and post-tests. Results: There was no significant difference between groups at pre-test for serum levels of leptin and glucose. After intervention, serum level of glucose in the aerobic group and serum level of glucose and leptin in the combined group were significantly reduced in compared to the controls (P<0.05). Conclusion: Aerobic and combined training with beneficial effects on the sera glucose level are recommended for patients with type 2 diabetes. However, combined training, regarding reducing leptin level seems to be more useful for these subjects.

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Background and Objective: Flax seed has been shown to play a role in the prevention and treatment of dislipidemia and inflammation, which may enhance the benefits of training. This study was done to determine the effect of 10 weeks of aerobic training with flax seed supplementation on blood lipids profile and C-reactive protein in obese women.

Methods: In this clinical trail study, 45 obese middle-age women were randomly divided into 3 groups. Aerobic training program was performed 50-60 min/d, 3d/wk, for 10 weeks. Subjects in aerobic training with flax seed supplementation were received 6-9 garms, daily of flax seed. Body composition and metabolic parameters were assessed before and after the training period.

Results: Flax seed supplementation significantly improved triglyceride, HDL-cholesterol TC/HDL, body weight, body mass index, waist circumference and fat mass (P<0.05). Flax seed supplementation in combination  with aerobic training significantly improved adiposity indices body weight,body mass index, waist circumference , fat mass, triglyceride, HDL- cholesterol, LDL- cholesterol, LDL/HDL and TC/HDL (P<0.05).

Conclusion: Flax seed is safe and effective for improvement of cardiometabolic health in obse women and combination of flax seed can enhance beneficial effect of training over a ten-week period.

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Background and Objective: Different physical activities affect on anti-oxidative system. Varity, period and intensity of activities are necessary in health improvement. This study was carried out to determine the effect of medium period of progressive anaerobic training on serum level of superoxide dismutase and Catalase in female rats.

Methods: In this experimental study, 30 female rats were randomly allocated into control and anaerobic training groups. The training program lasted for 8 weeks with control (without activity) and anaerobic including 3 sessions in a week with speed of 24-30 meters per minute in slope range (515) for 30 seconds.

Results: Serum level of superoxide dismutase was significantly increased in progressive anaerobic training group (109.1±17.3 U/ml) in compare to controls (98.8±12.8 U/ml) (P<0.05). Serum level of Catalase was 51.2±7.2 and 48.4±4.2 U/ml in control and progressive anaerobic training, respectively. This difference was not significant.

Conclusion: The medium period of progressive anaerobic training influences serum level of superoxide dismutase and Catalase in female rats.

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Background and Objective: Several studies have shown that high level of Endothelin-1 and Malondialdehyde lead to an increase in the risk of coronary artery diseases. This study was done to evaluate the effect of aerobic training on Endothelin-1 and Malondialdehyde in inactive elderly women.

Methods: In this quasi -experimental study, 21 inactive elderly women with range of 60-70 year non-randomly divided into experimental (n=11) and control (n=10) groups. The aerobic training including eight weeks aerobic training (with intensity of 50-70 percent of reserve heart rate), 3 times a week, and 60 minutes per session. Endothelin-1 and Malondialdehyde were measured at baseline and at the end of the study.

Results: After eight weeks of aerobic exercise, Endothelin-1 level reduced in intervention group (35.96%) and control group (41.09%) (P<0.05). After eight weeks of aerobic exercise there was no significat difference between intervention and control groups. After eight weeks of aerobic exercise reduce of Malondialdehyde level in intervention and control groups was not significant difference.

Conclusion: Regarding to reducing the serum level of Endothelin-1 in in the control and experimental groups, the aerobic training with moderate intensity did not lead to reduce in levels of serum Endothelin-1 in elderly women.

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Background and Objective: The synthesis of uncoupling protein 1 (UCP1) in adipose tissue plays an important role in providing resistance and prevention of fat accumulation, weight gain and obesity. This study was done to evaluate the effect of eight weeks aerobic training with moderate and high intensities on serum levels of Irisin and UCP1 white adipose tissue in obese male rats.
Methods: In this experimental study, 24 adult obese male Wistar rats (weight: 250 to 300 gr, BMI>30g/cm²) were randomly assigned into three groups including moderate aerobic training intensity, high intensity aerobic training and control group. The aerobic exercise training was included 8 weeks (5 sessions/per-week for 60 min per session). All training groups carried out aerobic training with 28 m/min (moderate intensity), aerobic training with 34 m/min (high intensity) on treadmill. 48 hours after the training period, the level of UCP1 and Irisin protein was measured.
Results: The level of UCP-1 in adipose tissue and serum Irisin in both aerobic training intensities increased compared to control group, but this increase only in aerobic training group with a moderate intensity was singnificant (p<0.05).
Conclusion: Eight weeks aerobic training with moderate intensity leads to increase of UCP-1 in adipose tissue and Irisin levels.