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Showing 9 results for Interval Training

Mohammad Reza Hamedinia , Zeynab Firozeh , Amir Hossein Haghighi , Saeid Ramezani,
Volume 21, Issue 1 (3-2019)
Abstract

Background and Objective: Increasing the cost of energy in obesity preventing and treating and reducing its complications can be achieved by stimulating the factors including Irisin and FGF21 associated with browning of the white adipose tissue. The aim of this study was to determine the effect of 12 weeks of light and heavy interval exercises on the level of irisin and FGF21 in obese and overweight women.
Methods: This clinical traial study was done on 35 overweight and obese women (39.8±3.85 years old and body mass index 27.1±3.37 kg/m2). The subjects were divided randomly into three groups of interval exercises including Heavy (n=12), light (n=12), and control (n=11) groups. The training program included 12 weeks of heavy and light interval exercises for 25 to 60 minutes per session and three sessions per week. Before and after the training period, irisin and FGF21 serum indices were measured for each subject.
Results: Serum level of FGF21 increased only after 12 weeks of heavy interval training (P<0.05). However, there was no change in serum irisin levels after both heavy and light interval exercises. Body fat percentage, waist to hip ratio, and BMI Subjects of light and heavy interval exercises reduced and VO2max increased significantly compared to control group (P<0.05).
Conclusion: 12 weeks of low and heavy interval training without altering serum levels of irisin have a beneficial effect on increasing VO2max and improving body composition. Also, heavy interval training has a significant increase in FGF21, Which can be effective in weight loss through the browning of white adipose tissue.
 
Arezoo Eskandari, Mohamad Fashi , Amir Bahador Dakhili ,
Volume 21, Issue 2 (7-2019)
Abstract

Background and Objective: Age is the greatest risk factor for cardiovascular disease that is associated with shortens telomere. TRF2 and TERT genes expression in heart tissue   reduce in elderly. These geness are associated with shortens telomere. Exercise can play a useful role in maintaining the length of telomeres. This study was carry out to determine the effect of high intensity interval training (HIIT) and continuous endurance training on TRF2 and TERT gene expression in heart tissue of aged male rats.

Methods: In this experimental study 24 adult aged male rats (88-96 weeks, 363±12 g) allocated into three groups including control, endurance training (5 sessions per week: with 60-70 of maximum speed of group) and HIIT (5 sessions per week: 80 percent in the first and second week, 90% maximum speed of the third week, 100 % until the end of the exercise for 6 weeks). Gene expression of TRF2 and TERT were assessment by Real-time - PCR and the quantification of gene expression levels using the Pfaffl formula.

Results: TRF2 gene significantly increased in HIIT and CET groups in compared to control group (P<0.05). TERT gene non- significantly increased in HIIT and CET groups in compared to the control group.

Conclusion: It seems, 6 weeks of high-intensity interval training and continuous endurance training to be able regulate the growth and longevity of the heart cells by maintaining the length telomere by increasing TRF2 gene expression.


Hossein Mahdian , Parvin Farzanegi , Amin Farzaneh Hesari ,
Volume 21, Issue 4 (12-2019)
Abstract

Background and Objective: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic hepatic diseases which may be associated with cardiovascular disease. This study aimed to consider the effect of combined therapy with resveratrol supplementation and interval exercise training on heart cells apoptosis in rats with NAFLD using TUNEL assay.
Methods: This experimental study was done on 35 Wistar rats. Animals were randomly allocated into five groups including control (healthy) and four NAFLD groups, including patient, resveratrol, interval exercise, and resveratrol + interval exercise. A TUNEL assay kit was applied for the detection of apoptosis in heart tissue.
Results: The patient group had significantly higher percentage of heart apoptotic cells (24.38±0.69%) compared to the other groups (P<0.05), while the resveratrol + interval exercise (9.02±0.49%) and resveratrol (9.47±0.83%) groups showed significantly lower mean levels of heart apoptotic cells compared to the patient and interval exercise (P<0.05) groups. There was no significant difference in mean of apoptotic cells between resveratrol and resveratrol + interval exercise groups. The mean of apoptotic cells in interval exercise group was 11.39±0.28%.
Conclusion: Nonalcoholic fatty liver disease is considerably associated with heart cells apoptosis. Resveratrol supplementation especially combined with interval exercise significantly reduces apoptotic cells in heart tissue.

Sajad Karimipour , Shila Nayebifar , Mahmood Fazel Bakhsheshi ,
Volume 22, Issue 1 (3-2020)
Abstract

Background and Objective: Researches has shown that exercise and nutrition exercises can have a different effect on serum Brain Derived Neurotrophic Factor (BDNF( levels and resting blood pressure in young people. This study was done to determine the effect of a period of High Intensity Interval Training (HIIT) with omega-3 supplementation on the serum levels of BDNF and resting blood pressure in inactive male students.
Methods: In this clinical trail study, 32 non-athlete male students were randomly divided into control, supplements, training and training + supplement. Subjects in supplementary group were received daily (2000 mg) of omega-3 capsules. The training groups were also subjected to HIIT training for 6 weeks. The training + Supplemental group also included a combination of the same training program were associated with omega-3 supplementation. BDNF levels were measured by ELISA method 24 and 48 hours perior the exercise protocol and after the last training session. Blood pressure disturbances were also evaluated at the same time and before blood sampling according to the recommendations of the British Heart Association.
Results: The serum levels of BDNF in the group after 6 weeks in the training + supplementation group and the training group increased significantly compared to the pre-test values (P˂0.05). Also, a significant difference between-group training + supplementation group and training, supplementation and control groups were observed (P˂0.05). Systolic and diastolic blood pressures were significantly reduced in training + supplementary, training and supplementation groups compared to pretest values (P˂0.05). A significant reduction in systolic blood pressure in the training + supplementation group was observed compared to supplemental and control groups (P˂0.05).
Conclusion: HIIT combined with supplementation with omega-3 supplementation improved the BDNF serum level and reducing resting blood pressure in inactive male students.


Masoumeh Nobahar, Marefat Siahkouhian , Shadmehr Mirdar ,
Volume 23, Issue 1 (3-2021)
Abstract

Background and Objective: People with asthma are at increased risk for cardiovascular disease and increased risk of death. Asthma is associated with the structure and function of vessel changes. In this regard, MicroRNAs, AKT and VCAM play an important role in endothelial function. So, the aim of this study was to investigate the effect of 12 weeks of interval training on expression of mir-126, mir-1185 AKT and VCAM in cardiac tissue rats with allergic asthma.
Methods: This experimental study was performed on 15 Wistar rats. Animals were randomly allocated into three groups (n=5) including healthy control, asthma control and asthmatic interval training. Ovalbumin solution was injected subcutaneously 3 times per week to asthma groups, and suffering from asthma was confirmed by increasing the amount of IgE. The asthma group participated in 8-week exercise training. The rats were anesthetized at the end of 8 weeks and then their heart tissue was isolated by surgical instrument and immediately placed in nitrogen fluid. Expression of mir-126, mir-1185, AKT and VCAM in rats cardiac tissue were evaluated.
Results: AKT and VCAM expression was significantly increased in asthma control group compared to healthy control group (P<0.05). mir-126, AKT and VCAM expression were significantly increased in asthmatic interval training group in compared to asthma control group (P<0.05) while Mir-1185 was significantly reduced in asthmatic interval training group in compared to asthma control group (P<0.05).
Conclusion: Interval training by increasing mir-126, by reducing the expression of mir-1185, AKT, and VCAM reduces the risk of atherosclerosis in rats affected with asthma.
Somaye Fakhri , Fatemeh Fakhri , Saeed Shakeryan , Aliakbar Alizaded ,
Volume 23, Issue 3 (10-2021)
Abstract

Background and Objective: Physical activity and the use of herbal supplements can affect liver enzymes. Nano-curcumin is an effective ingredient (deferulovl methane) in turmeric with antioxidant, antibacterial, antifungal, antiviral, anti-inflammatory and anti-proliferative properties and can play an important role in preventing liver fibrosis. This study was performed to determine the effect of 6 weeks of high intensity interval training (HIIT) with Nano-curcumin supplementation on liver enzyme levels in overweight female students.
Methods: This clinical trial study was performed on 48 overweight female students of Shahid Chamran University of Ahvaz, Iran with an average age of 21.7±1.32 years and a BMI equals 27.8±2.46kg/m2 during 2018. Participants were randomly divided into 4 groups: control, Nano-curcumin supplementation (One 80 mg capsule daily), training and training combined with nano-curcumin supplementation (one 80 mg capsule daily). Training groups performed an exercise protocol of HIIT training with maximum heart rate for 6 weeks (three sessions per week). Blood samples were obtained to liver enzymes measurement (ALT, AST and ALP) before and after the intervention period.
Results: Performing six weeks of high intensity interval training along with taking nano-curcumin supplemen led to a significant reduction in serum level of AST and ALT compared to control group (P<0.05). In the supplement-training group, a significant decrease was observed in serum levels of ALT and AST compared to pre-test (P<0.05). But no statistically significant changes were observed in ALP serum level.
Conclusion: It seems taking nano-curcumin supplement along with high intensity interval training have a favorable effects on improving some of the liver characteristics of overweight female students.
Fatemeh Shojaei , Saeedeh Shadmehri ,
Volume 23, Issue 4 (12-2021)
Abstract

Background and Objective: Eotaxin is a pre-inflammatory adipokinin secreted from adipose tissue that plays an important role in function regulating of adipose tissue. This study was done to determine the effect of high-intensity interval training on the gene expression of eotaxin in visceral adipose tissue and insulin resistance following metabolic syndrome in rats.
Methods: In this experimental study, 40 male Wistar rats (weight 180±20 gr) were selected and after 12 weeks of high-fat diet and the creation of the metabolic syndrome model were randomly divided into four groups including  control, metabolic syndrome, High-Intensity Interval Training (HIIT) and metabolic syndrome with HIIT. Rats in the high-fat diet were subjected to a special diet (30 to 40% fat) for 12 weeks to develop a model of metabolic syndrome. HIIT consisted of 5 to 10 interval 1-minute intensive running on treadmill at 80 to 95% of maximum speed and in slow alternations at 55% of maximum speed for 8 weeks. Insulin resistance using HOMA-IR mode is considered as a basic factor for determining metabolic syndrome.
Results: The gene expression of eotaxin and insulin resistance in the metabolic syndrome group were significantly higher than the control group (P<0.05). Gene expression of eotaxin and insulin resistance was significantly lower in HIIT and metabolic syndrome with HIIT groups than the metabolic syndrome group (P<0.05). Also, the gene expression of eotaxin and insulin resistance was significantly lower in HIIT group than the metabolic syndrome with HIIT group.
Conclusion: It seems that HIIT may be an important factor in down-regulating eotaxin and insulin resistance in metabolic syndrome.
Nasrin Alborzian Juneqani, Mohammad Fathi , Rahim Mirnasouri ,
Volume 25, Issue 1 (3-2023)
Abstract

Background and Objective: Understanding the cellular signaling mechanisms involved in muscle hypertrophy is considered a scientific challenge. Mammalian target of rapamycin (mTOR) is one of the regulatory factors in this process that increases protein synthesis in skeletal muscle through phosphorylation. This study aimed to determine the effect of six weeks of high-intensity interval training (HIIT) on phosphorylated mTOR protein in the quadriceps muscles of adult male Wistar rats.
Methods: In this experimental study, 16 adult male Wistar rats (six weeks old and weighing an average of 190.93±4.97g) were used. The animals were randomly divided into two groups of control and training (n=8). The training group underwent six weeks of HIIT on a treadmill, with five sessions per week. The load was increased during the six weeks from repeating the interval of 30 meters per minute for 30 seconds in the first sessions to eleven repetitions of the interval of 35 meters per minute for 30 seconds at the end of the sixth week, with rest intervals between the intervals at a speed of 13 meters per minute for 60 seconds. The control group did not undergo any training. The mice were anesthetized, and the Vastus lateralis of the quadriceps muscle was extracted. The level of phosphorylated mTOR protein in the quadriceps muscle was measured using the immunohistochemical method.
Results: HIIT significantly increased the levels of mTOR phosphorylation protein in male Wistar quadriceps femoris muscle compared to the control group (P<0.05).
Conclusion: Interval activity can have a positive effect on muscle hypertrophy through mTOR.
 

Seyedeh Fatemeh Fatemi , Seyed Abdollah Hashemvarzi , Minoo Dadban Shahamat , Amin Farzaneh Hessari ,
Volume 25, Issue 2 (7-2023)
Abstract

Background and Objective: Diabetes leads to impaired blood supply to the peripheral nerves. Sema3A (Semaphorin 3A) is a denervated protein that increases in response to hyperglycemia caused by diabetes. Exercise and alpha-lipoic acid (ALA) supplements can protect against diabetes-induced denervation. This study was done to evaluate the effect of high and moderate-intensity interval training with alpha-lipoic acid supplementation on the expression of Sema3A protein in the soleus muscle of Induced diabetic rats.
Methods: In this experimental study, thirty-five male Wistar rats (weight range: 190-220 g, 6-8 weeks old) were randomly allocated into seven groups of five: healthy control, diabetic, diabetic supplement (S), diabetic high-intensity training (HIT), diabetic moderate-intensity training (MIT), diabetic high intensity+supplement (HIT+S), and diabetic moderate intensity training+supplement (MIT+S). Diabetes was induced by injection of streptozotocin (50 mg/kg/bw). The HIT and MIT protocols were performed five days a week for six weeks. ALA was administered orally at 20 mg/kg daily by gavage. Immunohistochemistry was used to evaluate the expression of Sema3A protein in the soleus muscle. Serum insulin was measured by the ELISA method.
Results: Diabetes leads to increased level of glucose, Sema3A, and a significant decrease in insulin in the soleus muscle compared to healthy (P<0.05). HIT and MIT in combination with ALA, significantly showed lower expression of Sema3A Protein than in the diabetic group (P<0.05).
Conclusion: Although HIT and MIT can reduce the expression of Sema3A protein in the soleus muscle of diabetic rats, combining alpha-lipoic acid supplementation with exercise training is more effective in reducing the amount of denervation.



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مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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