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Showing 3 results for Colitis

Aslani Mm, Sheshpoli As, Sadeghiayn S, Alikhani My,
Volume 9, Issue 2 (7-2007)

Background&Objective: Shiga-toxin producing E. coli (STEC) belonging to several different O serotypes are one of the etiological agent of diarrhea. The STEC strains are considered as an etiological agent for enteritis after non-typhoidal salmonellosis and Campylobacter. They have also been associated closely with the hemolytic uremic syndrome (HUS) and hemorrhagic colitis(HC). The aim of this study was to determine of the frequency of STEC in patients with hemorrhagic colitis referring to Tehran hospitals. Materials&Methods: From March to September 2004, 70 patients with hemorrhagic colitis (Case)an 70 patients with diarrhea (Control) were included in this study. The stx gene was detected by PCR and was used for the determination of STEC strains. Slide agglutination with specific antisera used to detect O serogroup. Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) analysis of the flagellin gene (fliC) was performed for determining their flagellar antigen (H). Results: Two samples (2.9%) from Hemorrhagic colitis cases and 12 samples (17.1 %) from diarrheal cases were positive for STEC. There was no significant correlation between STEC and Hemorrhagic colitis but there was a significant correlation between STEC and diarrhea (p<0.05). STEC isolates O142:H48 serotype was from hemorrhagic colitis cases and O126:H47, O126:H6, O26:H4 and O111:H23 serotypes were from diarrheal cases. These serotypes were not reported in hemorrhagic colitis cases. Conclusion: Our data showed that there was no significant correlation between STEC and hemorrhagic colitis. This could be explained since serotype responsible for hemorrhagic colitis i.e. O157:H7 serotype is not present in Iran.
Takhshid Ma (phd), Ai J (phd), Tavasoli Ar (phd), Ebrahimi L (phd), Momenzadeh D (msc),
Volume 12, Issue 1 (3-2010)

Background and Objective: Ulcerative colitis is a chronic inflammatory bowel disease in which free radicals play an important role in its pathogenesis. It is supposed that diet enriched with Omega 3 fatty acid and antioxidant compounds can be effective in the treatment of this disease. Grape seed extract contains potent antioxidant compounds. The aim of the present study was to evaluate possible useful effects of fish oil and grape seed extract enriched diets on the reduction of colonic damage and inflammation in acetic acid induced colitis. Materials and Methods: In this experimental study 50 male adult Wistar rats were randomly divided into five groups (n=10). Fish oil group (F group) received 1.6 ml fish oil, grape seed group (G group) received 50 mg/kg grape seed extract and fish oil + grape seed group (FG group) received 1.6 ml fish oil + 50 mg/kg grape seed extract orally for 1 month. Rats in control group (C group) and colitis group (Co group) received distilled water. After 1 month colitis induced in groups with intrarectal administration of 1ml acetic acid (4%) to induce ulcerative colitis. The control group received intrarectal saline. Two days after the induction of colitis the degree of tissue injuries and inflammation were assessed by macroscopical and histopathological scores of colonic mucosa. Results: Acetic acid administration induced ulcers, inflammation and severe crypts damages in mucosal tissue of the colon. The rats with colitis in the FG group showed significantly less macroscopic, microscopic damages and inflammation in colonic tissues compared with those in colitis group. However treatment with grape seed extract and fish oil did not result in any significant improvements in macroscopic and microscopic scores. Conclusion: The result of this study showed that fish oil and grape seed extract enriched diets before colitis induction play a protecting role against damages due to acetic acid induced colitis.
Maryam Esmailpour , Sima Besharat , Taghi Amiriani ,
Volume 25, Issue 2 (7-2023)

Background and Objective: The diagnosis of inflammatory bowel disease (IBD) is performed by colonoscopy, sampling, and histopathology. Stool calprotectin is a test showing the presence of inflammation in the gastrointestinal tract. This study was done to determine the relationship between the calprotectin level in the feces and endoscopic findings in ulcerative colitis patients referred to the gastroenterology clinic in Gorgan, Iran.
Methods: This descriptive-analytical study was performed on 100 patients with ulcerative colitis referred to the gastroenterology clinic of Sayad Shirazi Hospital, Gorgan, north of Iran during 2020. The patients were asked to collect their stool samples one day before the procedure (just after taking the drug for bowel cleansing). Bowel cleansing was done by administering polyethylene glycol solution dissolved in water. The activity of ulcerative colitis was measured using the disease activity score. According to this criterion, a score greater than or equal to 5 is considered an active disease. Patients were classified into two groups: extensive or pan-colitis and left-sided colitis. Stool samples were evaluated for calprotectin in a single laboratory using a commercially available kit (Calprest- EuorociationspA. Trieste) at normal values of less than 50mg/g. The relationship between stool calprotectin with colonoscopic findings was evaluated.
Results: The average duration of infection was 4±3.1 years in the time range of 1-14 years. The calprotectin level was less than 50 μg/g in 16 patients. Stool calprotectin less than 50 µg/g was seen in only 16 patients. There was no significant relationship between the level of calprotectin and the either age or gender of patients. Most patients (84%) had active disease based on colonoscopic findings. Left-sided involvement was seen in 60% of patients. Fecal calprotectin level was significantly higher in those with acute phase and those with severe disease (P<0.05). Additionally, the calprotectin level had no significant relationship with the location of bowel involvement, extension, and disease duration.
Conclusion: This study showed that the fecal calprotectin level in patients with ulcerative colitis had a significant relationship with the severity and activity of the disease in north of Iran.

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مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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