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Showing 4 results for Blood Glucose

Hassani V (md), Pooreslami M (md), Niakan M (md), Sehat S (md),
Volume 1, Issue 3 (10-1999)
Abstract

Stress responses have been excited by the painful stimuli, after induction of anesthesia and during the operation. In order to reduce these responses, it will be useful to select the type of anesthesia. Based on this fact, two groups of patients (Every group had 50 patients) were selected randomly. All patients are older than 18 years old and were chosen according to America Society of Anesthesiologist, class I, II, and were candidated for cataract surgery. Propofol were used for induction and maintenance of anesthesia In group 1 (TIVA group). In group 2 (Balance anesthesia), Sodium Thiopental induced anesthesia and the combination of N2O and Halothane were used for maintenance of anesthesia, respectively. Blood Glucose in two groups was measured before induction of anesthesia that all were in normal range (80-120 mg/d). Then after induction, incision and 30 minutes after start of surgery, blood Glucose was measured again and deviation from basal level were classified in three categories as: <10%, 10-20%, >20%. The results demonstrated meaningful difference between two groups, statistically (Chi-square, P<0.001). Increasing the blood Glucose in group 2, in three stages, was more than group 1. Blood Glucose level was increased about 20% from its basal level, in the majority of group 2 (32% after induction, 64% after incision, 62% 30 minutes after start of surgery). But, this amount of increasing in group 1 was detected as follow. 16% after induction, 16% after incision, 12% 30 minutes after start of surgery. It is possible that in TIVA group’s, control of blood Glucose and stress responses better than balance anesthesia group’s. The comparative measurements of catecholamine level in both groups would be the next investigations.
Sh Ashgar Toosi , M Tehranipour , M Behnam Rassoli ,
Volume 19, Issue 3 (10-2017)
Abstract

Background and Objective: Diabetes mellitus is a metabolic disorder that is characterized by hyperglycemia resulting from defects in insulin secretion and action, or even both of them. Proveskia abrotanoides has anti-bacterial, anti-parasitic, antioxidant, anti-inflammatory, and analgesic effects. This study was done to evaluate the effect of hydro-alcoholic extract of Proveskia abrotanoides on blood glucose and liver enzymes level in streptozotocin-induced diabetic rats.
Methods: In this experimental study, 60 male Wistar rats were randomly allocated into including healthy control, healthy received Glibenclamide, healthy -treated with 150, 300 and 600 mg/kg/bw of Proveskia abrotanoides extract, diabetic control, diabetic treated with 150, 300 and 600 mg/kg/bw of extract, positive control (diabetic treated with the Glibenclamide). After the treatments, the blood samples were taken from the animals and the level of blood glucose and liver enzymes including ALT, AST, and ALP were measured. Finally, the effect of hydro-alcoholic extract of Proveskia abrotanoides was compared with Glibenclamide as a conventional drug.
Results: The results showed a significant increase in liver enzymes (ALT, AST, ALP) in hyperglycemic rats compared to the healthy controls (P<0.05). The mean of AST, ALT and ALP enzymes in hyperglycmia group were 286.83±7.46, 172.16±5.74, 526.17±8017, respectively while in healthy control it was 239±12.16, 100±2.42 and 196.33±6.82, respectively. In hyperglycemic rats treatment with doses of 150, 300, and 600 significantly reduced liver enzymes levels in compare to hyperglycemic contol group (P<0.05). In group treated with 150 mg/kg/bw, the average of ALP, AST, and ALT enzymes was 160.67±6.29, 127.33±5.23 and 260.33±7.18, respectively. The mean of ALP, AST, and ALT enzymes in group treated with 300 mg/ kg/bw was 197.5±6.71, 144.33±8.82 and 201.67±9.60, respectively. In group treated with 600 mg/kg/bw, the mean of ALP, AST, and ALT enzymes was 192.23±8.23, 111.17±6.13 and 329±7.43, respectively. The hydro-alcoholic extract of Proveskia abrotanoides significantly reduced serum glucose and liver enzymes in comparison with Glibenclamide group (P<0.05).
Conclusion: The hydro-alcoholic extract of Proveskia abrotanoides reduces liver enzymes and blood glucose level in streptozotocin-induced diabetic rats.
Farzad Sharifnezhad , Samira Eshghinia , Hamideh Akbari ,
Volume 23, Issue 4 (12-2021)
Abstract

Background and Objective: Diabetes is one of the most common non-communicable diseases with debilitating complications and mortality rate those results from insulin deficiency, resistance to it or both. The role of nutrition and some micronutrients in the development and progression of diabetes has been investigated. Studies have shown that Magnesium deficiency can reduce insulin secretion and cell resistance. This study was done to determine the association of serum Magnesium level with glycemic control, serum lipids and renal function in type 2 diabetes mellitus and pre-diabetic patients.
Methods: This case-control study was done on 70 patients with type 2 diabetes, pre-diabetes and 35 healthy individuals. Fasting glucose, HbA1c, lipid profile, creatinine and Magnesium were determined.
Results: Serum Magnesium level in diabetic and pre-diabetic patients were significantly lower than control group (P<0.05). Serum Magnesium level had reverses correlation with HbA1c in diabetic patients. Serum Magnesium level had reverse correlation with glycemic index (FBS, 2hpp) and creatinine in control group (P<0.05) were evaluated in all groups but there was no significant correlation between Renal function test (Cr, eGFR) and serum Mg level.
Conclusion: Serum Magnesium levels in diabetics and pre-diabetics were lower than healthy individuals and had reverse correlation with HbA1c in diabetic patients.
Soren Valafar , Eidy Alijani , Fariba Aghaei , Mahsa Mohsenzadeh ,
Volume 24, Issue 1 (3-2022)
Abstract

Background and Objective: Type 1 diabetes (T1D) is highly prevalent in the group of autoimmune and inflammatory patients. Tumor necrosis factor-alpha (TNF-a) and interleukin-10 (IL-10) plays an important role in regulating complex interactions between pancreatic beta cells and immune cells in the development of T1D. This study was performed to determine the simultaneous effect of resistance training and endothelial progenitor cell injection on blood glucose levels and protein expression of proinflammatory factors TNF-a and IL-10 in muscle tissue of streptozotocin (STZ) induced diabetic male rats.
Methods: In this experimental study, 36 male Wistar rats weighing approximately 200±20 g and six weeks old were randomly divided into six groups. Induction of diabetes was performed by intraperitoneal injection of STZ at a dose of 45 mg/kg body weight. Groups included diabetes + stem cell injection + resistance training group, diabetes + resistance training group, diabetes + stem cell injection group, control diabetic group to control the passage of time, and healthy basal and diabetic groups for defaults. Exercises were performed for 17 sessions of resistance training, including climbing ladders with increasing weight three days a week in the same laboratory conditions. Endothelial progenitor cells were cultured by femoral bone marrow aspiration and culture and then injection into the tail vein. 68 hours after the last training session, blood glucose levels were assessed by ELISA and the expression of TNF-a and IL-10 protein in muscle tissue was assessed by Western blotting.
Results: Endothelial stem cell injection, resistance training and resistance training with the simultaneous injection of endothelial stem cells significantly increased the anti-inflammatory factor IL-10 in the skeletal muscle tissue of diabetic rats in compared to control group (P<0.05). Expression of the anti-inflammatory factor IL-10 in the skeletal muscle tissue was significantly increased in resistance training plus the simultaneous injection of endothelial stem cells group in compared to injection of stem cells and resistance training groups (P<0.05). Glucose concentration in the skeletal muscle tissue was significantly reduced in resistance training plus the simultaneous injection of endothelial stem cells group in compared to injection of stem cells and resistance training groups (P<0.05).
Conclusion: It seems that 17 sessions of resistance training reduces blood glucose level and improves inflammatory conditions in response to an increase in IL-10 and a decrease in TNF-a in a group of diabetic rats with resistance training and simultaneous injection of endothelial progenitor cells in diabetic male rats.

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مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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