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Showing 2 results for Sadeghinezhad

Sadeghinezhad J , Mahmoudi Kordi F , Limoei H, Rostami S,
Volume 17, Issue 3 (10-2015)

Background and Objective: Several studies reported the immunological activity of Lycium barbarum. This study carried out to determine the effect of aqueous extract of fruits of Lycium ruthenicum L. on morphometric and histomorphometric indices in mice lymphatic organs. Methods: In this experimental study, 36 adult mice were randomly allocated into six experimental and control groups. The experimental groups were received Lycium ruthenicum L. fruit aqueous extract in the doses of 50, 100, 200, 400 and 800 mg/kg/bw, daily by feeding tube for 21 days. In the control group animals were recived 100 mg/kg/bw of saline using feeding tube. After the treatment, the relative increase in the body weight, morphometric, histomorphometric and histopathologic indices in thymus, lymph node and spleen were measured. Results: The administration of extract in doses of 50 and 100 mg/kg/bw did not effect on body weight of mice but in the doses of 200, 400 and 800 mg/kg/bw significantly reduced the body weight (P<0.05).Thymus index in 800 mg/kg/bw of extract significantly reduced in comparison with controls (P<0.05). Thickness of thymus medulla in low doses significantly increased while it was not visible in higher doses (P<0.05). Thickness of capsule in lymph node and spleen in dose of 800 mg/kg/bw significantly increased in comparison with control group (P<0.05). Low doses of the Lycium barbarum extract increased stimulation and infiltration of the immune cells and hematopoiesis in the lymphoid organs while in doses of 400 and 800 mg/kg/bw caused pathological changes including fibrosis in capsule, degeneration in follicles and stromal cell apoptosis. Conclusion: Aqueous extract of fruits of Lycium ruthenicum L. in doses of 400 and 800 mg/kg/bw causes histopathological alterations in the lymphoid organs.
Moslem Dahmardeh , Javad Sadeghinezhad , Zahra Tootian , Mojdeh Salehnia ,
Volume 22, Issue 1 (3-2020)

Background and Objective: Oxaliplatin is the main agent used in the treatment of colorectal cancers. Oxaliplatin inhibits DNA replication and transcription and to induce apoptosis or necrosis in cancer cells and rapidly dividing cell lines. This study was designed to determine the effect of Oxaliplatin on sperm parameters of 60 days old offspring during pre-pregnancy, pregnancy and lactation period in mice.
Methods: In this experimental study, 32 female NMRI mature mice were randomly allocated into 4 groups. Animals in control group were received 0.2 ml saline intraperitoneally (IP) during 21 days of pre-pregnany, pregnancy and lactation periods. Animals in experimental groups including pre-pregnant, pregnant and lactation groups were received 3 mg/kg oxaliplatin trice a week IP during 21 days before mating, during pregnancy and lactation periods, respectively. At the 60th postnatal day, all the male offspring were euthanized and sperm samples were obtained. Analysis of sperm parameters including count, motility, vitality, maturation and DNA integrity was done.
Results: Sperm count, motility and DNA integrity were significantly reduced in all three groups of Pre-pregnancy, pregnancy and lactation in comparison with control group (P<0.05). Moreover, the percentage of immature and dead sperms were significantly increased in oxaliplatin groups (P<0.05).
Conclusion: Admistration of oxaliplatin induces adverse effect on sperm quality in perinatal period. The greatest effect of this drug is on lactation period. Also, by increasing the time interval for oxaliplatin administration in mice to puberty of offspring, the adverse effects of this drug on the quality of sperm parameters are reduced.

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مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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