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Showing 2 results for Ilkhani

Masoomeh Nazifi (msc), Fatholah Fathi Azarbayjani (phd), Minoo Ilkhanipoor (phd), Farah Farokhi (phd),
Volume 11, Issue 3 (10-2009)
Abstract

Background and Objective: In recent years many studies have reported that aspirin could have beneficial effect on learning and memory in different diseases of central nervous system. The objective of present study was to explore the effect of aspirin on learning and memory of Rats in pentylenetetrazole kindling model. Materials and Methods: In this experimental study Rats were divided randomly into six groups (n=8). Animals in three groups received aspirin (15 and 30 mg/kg, orally) and saline, one week before and during induction of kindling, respectivley. Kindling was induced in these groups by administration of pentylenetetrazole (PTZ: 40 mg/kg, ip). Two groups of animals received only aspirin 25 and 30 mg/kg orally. Other group received only saline throughout the study and served as health control group. After induction of kindling the learning and memory of Rats was tested in shuttle box. Study was divided to three stages of adaptation, acquisition and retention test. Initial Latency (IL) time before electrical shock and Step through latency (STL) time, 20 min or 24h after acquisition was evaluated as learning and memory index. Locomotor activity was also evaluated in open filed test. Results: PTZ kindling significantly decreased Initial Latency and Step through latency time, 20 min or also 24h after acquisition, and aspirin significantly increased these times in kindled animals (p<0.05). Aspirin also had no significant effect on locomotor activity of animals. Conclusion: This study showed that the administration of aspirin to kindled Rats improved learning and memory impairments induced by pentylenetetrazole kindling.
Amir Bagher Ilkhani, Maryam Tehranipour , Saeedeh Zafar Balanezhad ,
Volume 22, Issue 1 (3-2020)
Abstract

Background and Objective: Sperm dysfunction and damage in spermatogenesis are the most common causes of male infertility. Diazepam is also a painkiller for benzodiazepines that can be addictive for a long time. This study was done to determine the effect of Diazepam on testicular tissue parameters and spermatogenesis in Rats.
Methods: In this experimental study, 30 Wistar male rats with a 250-200 gram weight were randomly allocated into 5 groups. Experimental groups were received diazepam with doses of (2, 3, 4, 5 mg/kg/bw) for 14 days, intraperitonally. Serum physiology was injected in control group. The animals were anesthetized and the testes and epididymis ductus defran were removed for examination, sperm motility, and percentage of live sperm.
Results: Weight, large and small testicular diameter, percentage of live sperm and number of sperm moving forward were reduced with injection groups, at a dose of 3 mg / kg in all factors except the number of sperm moving forward in compared to the control group. In other groups, only testicular weight was significantly reduced at a dose of 2 mg/kg (P<0.05).
Conclusion: Diazepam can affect spermatogenesis process in rats.

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مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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