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Solvent exposure can affect human health. It can cause different effects in different part of the body. One of the most important side effects is neurobehavioral symptom including mood disorders, short memory, and tiredness. To determine the frequency of neurobehavioral effects in patients of a car producing plant in Tehran and comparing them with other workers in the same plant whom was not being exposed to such solvents. All of car painters (78 persons) as our case group and 83 non-painters as our control group were selected by simple random sampling and neurobehavioral abnormality was assessed by Q16 questionnaire. Neurobehavioral disorders based on above questionnaire was observed in 46% of car painters vs. 36% of non-painters (P=0.10). The significant differences were observed in perspiration without any particular reason (Q8) and feeling irritated without any particular reason (Q4). There was not a significant difference in observed frequency of neurobehavioral abnormalities in patients vs. non-painters, however both of these frequencies were higher than expected frequency reported in other reports.

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Hydatidosis is a parasitic infection mostly in found in the liver and lung due to echinococus species. But occurrence in other locations is possible. Purpose of this report is to describe a case of bilateral Hydatid cyst in ovaries. Clinical findings with this uncommon location are poorly specific and diagnosis required histologic examination after surgical removal. Imaging and serology is useful to differentiate Hydatid cyst from benign and malignant tumors. This obligatory to examine lung and liver as the main sites of cyst when you are being faced with unusual location of Hydatid cyst especially in endemic area such as Iran. Our patients was a 35 years old woman with history of 4-month abdominal pain in left and right lower quadran. Sonography showed two cysts in adenexal lesions after surgical removal, they were sent to pathology lab. Hydatic cyst membrane was seen in histologic examination of two cystic masses.

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Background & Objective: Addiction threatens the foundation of society and families. Addiction also causes a lot of material and spiritual losses. The addicted people are susceptible to infections with low resistance against disease. The aim of this project is to investigate the immunoglobin serum level in the Opium addicted and compare it with people whom addict to anything including cigarette. Materials & Methods: In this study 5 cc of blood was taken from each of 150 addicts and 150 healthy people of the same age and sex. Third blood serums were then separated and their immunoglobulin M, immunoglobulin G and immunoglobulin A were determined by SRID method. Results: Mean±SD of IgM in healthy and addicted subjects were 123±32.85 mg/dl and 109.5±47.28 mg/dl, respectively (P<0.05). Mean±SD of IgG in healthy and addicted subjects were 1008±354.38 mg/dl and 1307.2±291.07 mg/dl, respectively (P<0.05). Conclusion: We conclude that the average amounts of IgG, IgM are lower significantly in addict’s compare to healthy results from the other studies in other countries has a good correlation with the finding from present research.

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Background & Objective: Dyslipidemia and smoking are among the most important medical problems in human society. Their share in the mortality of coronary heart disease (CHD) has led to multiple investigations about them. This study was done to determine the prevalence of dyslipidemia and the effect of cigarette usage on it. Materials & Methods: This epidemiological cross-sectional study was carried out on 9632 persons selected randomly in Tehran urban with a minimum age of 20 years and over. We measured fasting blood sugar, blood sugar 2 hours after 75 grams oral glucose, triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol. Degree of physical activity was registered according to Lipid Research Clinics classification. Anthropometrics data, social condition, family history and smoking exactly delineated. Our patients were divided into: those having normal lipid profile and primary dyslipidemia (without any risk factor for dyslipidemia) and secondary dyslipidemia (having one or more risk factors such as diabetes mellitus). ANOVA, t.test, and logistic were used to analyze the level of significance. Results: Our population sample consisted of 5619 female and 4013 male. 68.5% of our cases had dyslipidemia. 65.8% of females and 72.3% of males had at least one type of dyslipidemia. There were 1085 smokers (11.4%) that 73.2% of them were dyslipidemic. With comparing smokers to nonsmokers shows that in smokers HDL.cholesterol, LDL.cholesterol and total cholesterol had decreased and triglyceride increased (p<0.05). Conclusion: Tehran population suffers from dyslipidemia. Large number of secondary dyslipidemia and smoking highlighted the importance of education to overcome to these preventable and modifiable factors.

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Background&Objective: Thalassemia is the most common genetic disorder, 2-3 million carriers and 20 thousands with major thalassemia exist in our country. National prevention program of thalassemia started in 1998 and to encourage carriers to dispense marriage with increasing their knowledge was its main strategy. This study was designed to determine the effectiveness of thalassemia prevention program on couples knowledge and carriers and marriage avoidance in Gorgan province- Iran Materials&Methods: In this cross-sectional study, the data were collected by the questionairs which their validity and reliability were already confirmed. The sample population consist of 282 couples which were going to get married 107 couple with minor thalassemia which cancelled their marriage during 1998-2003 were also included in the sample poulation in this research. The detailed study were carried out on whole subjects. Data were entered into the SPSS and analyzed by chi-square, t-test and ANOVA. Results: In 282 couples, mean age was 20.5 on women and 24.86 in men, 57.8% were urban residents, 39.4% were relatives. Most of men had self-employed job and women were house keeper and half were under high school diploma. Distribution of knowledge level: 2.5% weak, 9.2% moderate, 53.2% good and 29.1% excellent. Relationship between knowledge and educational state, residency and job was meaningful (P<0.05), and there was not any relationship with age, gender and familial relativity. Ten couples were carrier that two of them were avoided from marriage. Also 43% of 107 carrier's couple whome were diagnosed in 1998-2003 avoided to get marriaged, meaningful relationships between subjects residency, education status and relativity (P<0.05). Conclusion: In spite of having a good knowledge, but some of the samples population in this study, did not show a suitable practice and most of high risk couples enter into marriage.

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Background and Objective: Treatment of the femural shaft fracture is imporoving. The aim of this study was to compare the outcome of Dynamic Compression Plating (DCP) and intramedullary nailing in the femural shaft fracture. Materials and Methods: This clinical trial study was done in orthopedic department of Shahid Kamyab Hospital in Mashhad – Iran during 2002-03. 40 patients with open fracture of femur divided into two groups. One group was treated by dynamic compression plate and the other group by intramedullay nailing. Follow-up time was 9-14 months. Results: Out of 40 patients, 75% were male. The time of clinical and radiological bone :::::union::::: was the same in both groups. There was 4 implant failure in the plate group (P<0.05). There was one deep infection in the intramedullary nailing group. Conclusion: This study showed that there is no difference between plate and intramedullary nailing group according time of bone :::::union:::::. But because of 4 implant failure in DCP groups, intramedullary nailing is recommended for femural shaft fracture.

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Background and Objective: Today, drug abuse is one of the most important medical and social problems of world population, which can be a threat to human’s health. Cannabis as a common substance can create psychotic symptom, psychiatric disorders and antisocial behaviors. This study was designed to compare the prevalency of psychoticism and neuroticism among cannabis and non-cannabis abusers in this region of the country. Materials and Methods: This case control study was done on100 cannabis users whom seek for drugs in public gardens of Golestan province as case group and 100 non-abusers who spend their leisure time in this place as control group. Two groups matched with regard to age and education level. The data gathered by using self-reported adult version of Eysenck Personality Questionnaire (EPQ). The data was analyzed in the SPSS-13.5 software by Chi-square, t-test and Mann-Whitney. Results: The mean score of psychoticism and neuroticism in case and control group was 9.37 and 5.72 respectivley (P<0.05). The mean score of neuroticism in cases and controls was 15.9 and 12.19, respectivley (P<0.05). The relationship between psychoticism and patterns of cannabis consumption was significant (P<0.05). There was a relationship between cannabis consumption and the history of drug misabuse in other substances in cannabis users and in their families. Conclusion: The result of this study can clarify the importance of preventing intervention in substance abuse for improving mental health.

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Background and Objective: The majority of medicines are associated with some form of side effects due to high prevalence of self- medication in Iran .There is not any drug without side effects the prevalence of self- medication in Iran's provinces is increasing. This study was done to determine the knowledge and practice among woman about self -medication based on health belief model. Materials and Methods: This cross- sectional study carried out on 385 women whom referred to health centers in Isfahan, Iran during 2008. Data were collected by a questionnaire including knowledge, practice and health belief model structures. Results: The mean score of knowledge was 82.97±13.80 and means score of perceived susceptibility 72.48±17.11, severity 71.60±14.73, benefits 68.29±17.13 and barriers 61.64±19.67. 86% of women have done self–medication at least in one disease in 6 months earlier Including: cold 225 (57.6%), headache 28 (53.7%) and anemia 51 (13.2%). The main reasons for self –medication were previous experience and medicine accessibility .The main reasons to avoid self –medication was the side effects of medicine. Conclusion: Self-medication can be prevented thought increasing knowledge and education about severity of drug side effects.

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The Iranian elderly population is rapidly growing. Currently more than 5 million Iranians are over 60 years of age which corresponds to nearly 7.26 percent of the population of the country. It is estimated that more than 10 percent of the population of the country will be elderly in the forthcoming twenty years. Structural and physiological changes which occur in the elderly cardiovascular system include: stiffness of the vasculature, decreased relaxation capacity of the heart during diastole, decreased efficiency of cardiac contraction during exercise, weakened heart muscle response to stimulation by adrenaline, and orthostatic hypotension. In the elderly people we are confronting with increased frequency of cardiovascular diseases especially myocardial infarction, stroke, isolated systolic hypertension, calcific aortic stenosis, orthostatic hypotension, and syncopal attacks due to sick sinus syndrome, complete heart block, atrial fibrillation or other rhythm disorders. Alteration in cardiovascular status in the elderly has undesirable effects on their quality of life and longevity. Myocardial infarction is the most common cause of death in the elderly however cardiac arrhythmias and valvular heart disease are other important cardiovascular disease in the old people. Diagnosis of these disorders in the elderly requires special consideration since coexistence of structural/functional changes in the old age with cardiovascular disease would alter the classic features of these disorders and result in delay in their appropriate management. Biological aging as evaluated by reduced telomere length has a strong impact on the incidence of cardiovascular disorders especially coronary heart disease and chronic heart failure. This phenomenon could possibly explain interindividual susceptibility to cardiovascular disorders.

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Background and Objective: Although acquired immune deficiency syndrome (AIDS) is a vital medical problem but it is more prominant as a personal behavior social cultural phenomenon. Adolescents have been identified as risk population in immune deficiency virus. Health education is only effective method to prevent AIDS. This study was carried out to determine the effect of educational program on knowledge and health belief model structures about acquired immune deficiency syndrome (AIDS) among high school female student in Isfahan, Iran. Materials and Methods: This quasi-experimental study conducted on 72 female students whom divided equaly into case and control groups. The questionnaire included demographic characteristics, knowledge and health belief model. Educational interventions were performed in lecture and group discussion. Data were analyzed using SPSS-18, paired t-test and independent t-test. Results: There were no significant differences in knowledge, perceived severity, benefits and barrier in two groups before intervention. After intervention, there were significant increases in knowledge, perceived severity, perceived benefits and perceived barriers (P<0.05), in the intervention group, but there was not significant increases in perceived susceptibility. Conclusion: Education based on health belief model can improve knowledge, perceived severity, benefits and barriers in female student. More educational sessions are required for improving perceived susceptibility in high school female students.

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Background and Objective: Klebsiella species are gram-negative bacteria with positive voges proskauer (VP) reaction. Klebsiella species are found as commensal in human digestive and respiratory system. This group of organisms can create a serious health hazards in hospitalized patients, and their ability to drug resistance is a major health problems. This study was done to evaluate the efficacy of Ciprofloxacin, Ceftizoxims and Carbenicillin on Klebsiella species isolated from hospital specimens. Materials and Methods: In this laboratory study, 1200 clinical samples were isolated from patients in Imam Khomeini hospital, Tehran, Iran. The identification Klebsiella species were carried out according to conventional biochemical tests. The minimum inhibitory concentration (MIC) of carbenicillin, ceftizoxime, and ciprofloxacin antibiotics were determined using Macrodilution broth test. Results: Out of 1200 isolated samples, 25% were identified as Klebsiella species. 73% of identified Klebsiella were obtained from urine samples. Klebsiella.peumoniae with rate of 94% was the most abundant among other species. The results of MIC and minimum bactericidal concentration by using standard microdilution method showed drug resistance range of 16-1024 μg/ml, 4-256 μg/ml and 0.25-16 μg/ml for carbenicillin, ceftizoxime, and ciprofloxacin, respectivley. In general, 94%, 6% and 1% of species were resistance to carbenicillin, ceftizoxime and ciprofloxacin, respectively. Conclusion: Ciprofloxacin and Ceftizoxime are suitable for the treatment of infections due to Klebsiella species.

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Background and Objective: Coronary artery diseases are one of the main causes of mortality and morbidity. This study was done to determine the prevalence of risk factors for coronary artery diseases in patients referred to angiography center in Sari, Northern Iran. Materials and Methods: This descriptive study was performed on 2540 patients referred to angiography center in Sari city, northern Iran, during 2005-10. Risk factors including diabetes, hypertension, hyperlipidemia, smoking, Family history, CRP and also ECG changes, type and number of involved artery and the severity of vascular involvement were recorded for each patient. Results: Hypertension, hyperlipidemia, diabetes, smoking were seen in 40.8%, 40.5%, 29.1%, 12.5% of patients, respectively. Positive family history and CRP were found in 10% and 3.4% of the patients, respectively. 23.8% of patients had abnormal ECG. One, two and three vessel diseases were observed in 26.5%, 48.3%, 48.3% of cases, respectively. Left anterior descending artery constriction was seen in 75.8% and 80.4% of males and females, respectively. A significant relationship was found between diabetes and left coronary circumflex (P<0.04) and left anterior descending artery (P<0.03) constriction. Conclusion: Diabetes, hypertension, hyperlipidemia, smoking, family history, abnormal ECG are among the risk factors of coronary artery diseases in this area.

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Background and Objective: Gastroenteritis due to Salmonella is common in human and considered as a global dilemma of public health. This study was done to determine the Pattern of serotyping and antibiotic resistance of Salmonella in children with diarrhea in Iran. Methods: In this laboratory study, 306 stool samples were collected from children with diarrhea in public health centers in Robat-karim, Tehran province, Iran. The specimens were enriched in Selenite F medium and then cultured on Hekton agar. The identification of Salmonella was carried out by conventional method and antimicrobial susceptibility testing was performed according to CLSI procedures. Results: Out of 306 stool samples, 7.2 % were identified as Salmonella species, as follow: 7 Salmonella typhi, 6 Salmonella paratyphi B, 3 Salmonella paratyphi C, 2 Salmonella paratyphi A and 4 samples were not identifiable. There was a significant relation between presence of WBC in fecal and salmonellosis (P<0.05). In drug sensitivity trends, 92.3% of Salmonella species were sensitive to chloramphenicol, ceftizoxime, Nalidixic acid and Amikacin. Conclusion: This study showed that Salmonella was the cause of children diarrhea in 7.2% in this region.

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Background and Objective: The Detection of neurologic signs for topographical disorders in central nerves system can prevent unnecessary neuroimaging techniques such as MRI. This study was performed to determine the diagnostic value of physical examination for topographic detection of infratentorial lesions in patients with cerebrovascular syndromes. Methods: This descriptive study was done on 200 patients with cerebrovascular syndrome in Qaem Hospital in Mashhad, north-east Iran during 2011. Regarding to topographic physical examination, sensitivity, specificity, positive and negative predictive value and accuracy of signs of syndromes were compared to MRI as gold standard method. Results: The accuracy of tetraparesis and crossed syndromes for localization of brain lesion in brainstem was 79% and 83%, respectively. The accuracy of hemiataxia for localization of brain lesion in ipsilateral cerebellar hemisphere was 98%. The accuracy of Wallenberg syndrome for localization of brain lesion in posterolateral medulla was 98%. Conclusion: Using clinical neuro-examination skills and accurate topographic physical examination can prevent unwanted MRI technique for the diagnoses of cerebrovascular syndromes.

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Background and Objective: Free radical production andsubsqunt oxidative steress can be due to hyperglycemia and its oxidation. This study was done to evaluate the effect of swimming training test and Fenugreek seed extract on plasma glucose and antioxidant activity in heart tissue of streptozotocine – induced diabetic rats. Methods: In this experimental study, 50 male wistar rats were allocated into five groups diabetic (DC, n=10), healthy control (HC, n=10), swimming training (S, n=10), swimming training + Fenugreek seed extract (1.74 g/kg/bw) (SF1, n=10), and swimming training + Fenugreek seed extract (0.87 g/kg/bw) (SF2, n=10). Streptozotocine (60 mg/kg/bw) was used for induction of diabetes in DC, S, SF1 and SF2 groups. Serum glucose and the rat heart tissue antioxidant enzymes activities of superoxide dismutase, Catalase and Glutation peroxidase were determined. Results: Body weight in all groups were significantly reduced in comparsion with healthy control group (P<0.05). Plasma glucose level significantly reduced in SF1 and HC groups compared to diabetic group (P<0.05). Cardiac antioxidant enzymes in swimming training, SF1 and SF2 groups significantly increased in compare to diabetic group (P<0.05). Conclusion: The combination of endurance swimming training and fenugreek seed extract can reduce plasma glucose and increase cardiac antioxidant enzymes in streptozotocine – induced diabetic rats.

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Background and Objective: Yersinia is a gram-negative bacillus that cause diarrhea through consumption of contaminated food and water.  This study was performed to identify the atypical Yersinia virulence markers isolated from children with diarrhea.

Methods: This descriptive cross -sectional study was done on 384 fecal samples of 0- 14 years old children admitted at children medical center from August 2011 to August of 2012. Fecal samples, for the enrichment, after 21 days of incubation in alkaline buffer with pH=7.2 at 4degree C, on days 7, 14 and 21 samples were cultured on CIN agar and Mac agar and then confirm the differentiation atypical Yersinia from other typical Yersinia species from fermentation of different sugars. Isolates were tested for marker of virulence including calcium dependence, auto agglutination, Congo red uptake and binding of crystal violet.

Results: Out of 384 stool samples, 4 (1.04%) were infected with Yersinia (Yersinia frederikseni, Yersinia kristensenii and Yersinia enterocolitica). Out of these three, only two samples in association was positive with virulence markers.

Conclusion: Phenotypic markers can be used to study the properties of phenotypic strains of Yersinia.

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Background and Objective: Smoking is one of the important risk factors for many diseases and increases the premature death.Transtheoretical models is one of the behavioral models for behavior understanding specifically in addictive behaviors. This study was done to evaluate the application of transtheoretical model to determination of smoking behavior among smokers.

Methods: This descriptive - analytical study conducted on 450 male smokers in Gorgan, northern Iran during 2014. Data gathering instruments were Diclemente smoking stages of change, Velicer decisional balance and temptation, Prochaska processes of change measurements along Fagerstrom test for nicotine dependency.

Results: Based on the stages of changes, 39.1%, 13.8%, 42.4%, 2.7% and 2% of subjects were in precontemplation, contemplation, preparation, action and maintenance stage, respectively. There was a significant relationship between stages of change with all transtheoretical model variables and nicotine dependency (P<0.05). Cons of smoking, self-reevaluation, self-liberation, and social liberation had the highest effect while helping relationship had the lowest effect.

Conclusion: Cons of smoking, self-reevaluation, self-liberation, and social liberation had the strongest predictors of smoking stages movement. Helping relationship had the lowest predictor of smoking stages movement.

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Background and Objective: Biofilms caused by pathogenic microorganisms that plays an important role against human health. Due to their resistance to detergents and antimicrobial agent, treatment response of affected patients with these bacteria is difficult. This study was done to evaluate the effect of methanol extract of Nasturtium officinale plant on growth and biofilm formation of Pseudomonas aeruginosa.
Methods: In this descriptive - laboratory study, the extraction was done by Maceration in 80% methanol and by rotary evaporator. The minimum inhibitory concentration (MIC) of Nasturtium officinale extracts were determined by broth microdilution method. Biofilm formation was investigated using the microtiter plate and stained with crystal violet.
Results: The minimum inhibitory concentration of Nasturtium officinale against Pseudomonas aeruginosa was 0.625 mg/ml and the Minimum bactericidal concentration of this extract was 1.25 mg/ml. PAO1 strain and 5 clinical strains were able to biofilm formation. Inhibition of biofilm formation by extract of Nasturtium officinale plant was dependent to concentration. The highest percentage of inhibition of biofilm formation was in the concentration of 7.5 mg/ml and the lowest percentage of inhibition of biofilm formation was in the concentration of 0.11 mg/ml. The mean of Pseudomonas aeruginosa biofilm inhibition by Nasturtium officinale extracts was 72.69±22.27 %. In the concentrations of 7.5, 0.93, 0.46, 0.23 and 0.11 mg/ml, there was a significant difference between clinical strains and PAO1 strain (P<0.05).
Conclusion: Methanolic extracts of Nasturtium officinale plant has anti-bacterial and anti-biofilm effect against Pseudomonas aeruginosa.

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Background and Objective: Organic aromatic compounds as common environmental pollutants can be existing in the effluent of different industries in concentrations ranging from trace quantities to hundreds of milligrams per liter. Phenol compounds extremely have been used in pharmaceutical, wood industry and paper and dyes industries which introduced to environment via effluents. This study was done to evaluate the efficacy of persulfate activated by Fe²⁺ in the present of UV for removal of phenol from aqueous solutions.
Methods: This photocatalytic degradation experiment was performed in batch mode using a 2.5 L cylindrical reactor equipped with low-pressure Hg vapor lamp of 55 W for wavelength production of 253.7 nm. The effects of operating parameters such as pH of the solution (pH: 3-10), different initial persulfate concentration (10-75 mmol/l), initial Fe²⁺ concentration (5-30 mmol/l) and initial phenol concentration (10-100 mg/l). Concentration changes of phenol were determined using UV–VIS spectroscopy at the wavelength of 500 nm.
Results: Degradation of phenol was significantly decreased with increasing of pH from 3 to 10, whereas the highest phenol removal rate was 82% at pH=3 in 45 min contact time. Also, the phenol removal rate is depending on initial persulfate and Fe²⁺ concentration. The degradation of phenol by this photocatalytic followed first order rate decay kinetics (R²>98%(. Under optimum operational conditions, the removal of TOC was obtained to be 61% in 45 min contact time.
Conclusion: This study indicated that activation of persulfate by Fe²⁺ in the present of UV process could serve as a novel treatment technique for removal of phenol in aqueous solution.
 

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Autosomal recessive primary microcephaly; MCPH is a rare neurologically condition observed in new born at the birth. Most patients suffer from moderate to severe intellectual disability. In this review article, we introduce MCPH disorder; include all of the chromosomal locations, kind of MCPH genes and numbers of mutations, functional efficacy, how to identify the genes separately and diagnostic algorithm of articles and data base such as OMIM, HGMD. 23 locations genes (MCPH1-23) have been recognized causes primary microcephaly in different population, so far. Function of them is to correct orientation of mitosis spindles, duplication of DNA, organization and function of centrosome, transfer of vesicles, transcription regulation, response to DNA lesion, etc. According to investigations, MCPH in Iran and Pakistan population is common because of more consanguinity marriage. MCPH1 and MCPH5 genes are more common in Iran. Recent advances in molecular biological techniques and animal models have helped to identify the genetic cause of microcephaly and open up the horizons for researchers in the field, and also elucidating of the underlying molecular mechanisms will improve our understanding of the structure and function of the brain.