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Background & Objective: Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. Considering the evidence on antidiabetic effect of Allium ampeloprasum (AA), this study was designed to investigate the analgesic effect of Allium ampeloprasum on formalin-induced nociceptive response in streptozotocin (STZ)-induced diabetic rats.

 

Materials & Methods: 45 male rats were randomly divided into control, AA-treated control, diabetic, sodium salicylate (SS)-treated diabetic, and AA-treated diabetic groups. For induction of diabetes, STZ was used at a 60mg/kg dose. The treatment groups received oral administration of AA-mixed pelleted food (6.25%) for one month. After one month, for all animals, blood glocuse concentration and formalin test measured. Data analyzed with using student paird t-test and ANOVA.

 

Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test (p<0.05) and AA treatment for one month did cause an improvement in this regard (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test (p<0.05).

 

Conclusion: This study indicated that one month administration of Allium ampeloprasum could attenuate nociceptive score in an experimental model of diabetes mellitus.

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Background and Objective: Reduction of serum glucose and lipids in diabetic patients due to medicinal plants is clinically very important. Therefore, the effect of Allium schoenoprasum feeding on blood glucose and lipids was investigated in male streptozotocin-diabetic Rats. Materials and Methods: In this experimental study, male Wistar Rats (n=32) were divided into 4 groups, i.e. control, Allium schoenoprasum -treated control, diabetic, and Allium schoenoprasum -treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food at a weight ratio of 6.25% one week after the study for 6 weeks. For induction of diabetes, streptozotocin was administered at a dose of 60 mg/kg (i.p.). Serum glucose and lipids levels were determined before the study and at 3rd and 6th weeks after the study. Results: Serum glucose was significantly lower in Allium schoenoprasum -treated diabetic Rats at 3rd and 6th weeks as compared to untreated diabetics (p<0.05). In addition, serum total cholesterol did not show a significant change at 6th week in Allium schoenoprasum -treated diabetic Rats as compared to untreated diabetics. There was also a significant lower level of triglyceride in Allium schoenoprasum -treated diabetic Rats (p<0.05) and Allium schoenoprasum treatment caused significant improvement in HDL- and LDL- cholesterol levels in treated diabetic group as compared to untreated diabetic group (p<0.05). Conclusion: This study showed that oral administration of Allium schoenoprasum to streptozotocin-diabetic Rats at a food weight ratio of 6.25% has a significant hypoglycemic effect, reduces serum triglyceride and LDL-cholesterol level and increases serum HDL-cholesterol.

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Free radicals are unstable molecules in reaction with other molecules lead to a variety of injuries and illnesses. However, to prevent the injuries, enzymatic and non-enzymatic antioxidants react with free radical in various forms. Free radicals and antioxidant enzyme acts by various mechanisms, although age, gender and physical activity affects on these reactions. Different responses and adaptation are experienced to oxidative stress among women and men, young, elderly, subjects with physical fitness and untrained subjects. The present article reviewed the effect of oxidative stress due to exercise-induced adaptations.

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Background and Objective: Hospitalization of patients in the intensive care units frequently results in anxiety of the family members. This study was performed to investigate the effect of a family-centered clinical intervention on the anxiety of family members of the patients hospitalized in intensive care units.

Methods: In this clinical trail study, eighty family members of the patients hospitalized in the intensive care units were randomly divided into interventional and control groups, respectively. In the interventional group, the family members were allowed to be present at the bedside from the second till the sixth day.The participant's level of anxiety was assessed in the second and the sixth day of patient's hospitalization using hospital anxiety and depression scale. Oral information about the equipment and the regulations and, a daily information card consisting of treatment and care activities, vital signs and patient's level of consciousness was delivered to the participants and their questions were answered.

Results: In the the sixth day, there was a significant difference between the mean anxiety scores in the intervention (11±3.22) and control group (7.05±3.44) (P<0.05). Also, the frequncey of anxiety in the interventional group (56%) was significantly higher than the control group with 15% (P<0.05). The odds ratio for anxiety in sons/daughters was lower than other family members in the sixth day (P<0.05).

Conclusion: Providing information, presence at the bedside and participation in the care of their patient increase the anxiety of family members in the first week of patient hospitalization in the intensive care unit.

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Fibrodysplasia ossificans progressiva (FOP) is an extremely rare autosomal dominant disorder having variable expressivity with complete penetrance. FOP incidence has been estimated to be 1 per 2 million. FOP caused by mutations in ACVR1 gene encoding bone morphogenetic protein type-1 receptor. To date, 15 types of mutations have been reported. The majority of cases were determined to be the rsult of a new mutation occuring sporadically. Here we report a 20 years old girl who's suffering FOP for 11 years.

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Aging is an inevitable process, which is associated with the development of various diseases such as cardiac hypertrophy. Hypertrophy can occur in both pathological and physiological form. Both types can be divided into a variety of eccentric and concentric types. In the present review, we present the effects of aging and exercise on patological and physioligac cardiac hypertrophy, oxidative stress and some of the mitogen-activated protein kinases with using 79 articles which acceable in pubmed and SID indexing which published during 1976-2016. If the age is associated with inactivity, leads to pathological heart hypertrophy. Meanwhile, the role of the protein family of kinases activated with mitogen and oxidative stress is important. Adolescence, if accompanied by low activity, can lead to increase oxidative stress through mitochondrial dysfunction. Oxidative stress can affect the activity of MAPKs. MAPKs have important role in wide variety of biological events, such as proliferation, differentiation, metabolism, mobility, survival and apoptosis. The tipping point of signal transduction and the regulation of these biological events bigin initially by the four MAPK subunits, including extracellular signal regulated kinase (ERK1 / 2), c-Jun NH2-terminal kinase (JNK1, -2.3) kinase P38 (A, B, y, S) and large MAPKs (BMKs or ERK5s). This paper focuses on two types of ERK1 / 2 and P38 that play an important role in the development of cardiac hypertrophy. ERK1 / 2 and P38 amounts change with aging. These changes are associated with the development of pathological hypertrophy. Sports activities can control the pathological pathway of hypertrophy and can lead to physiological hypertrophy. Exercise can control or reduce oxidative stress, ERK1 / 2 and P38 and ultimately can affect cardiac hypothyroidism.

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Background and Objective: Fibromyalgia syndrome is a chronic disease with extensive musculoskeletal pain that primarily involves women and also it has negatively effects on many aspects of psychological and social life. Cognitive-behavioral therapy examines dysfunctional emotions and maladaptive cognitive behaviors, processes, and themes, and cognitive-behavioral hypnotherapy combines hypnotherapy with the methods and concepts of cognitive-behavioral therapy. The aim of this study was to compare the effectiveness of cognitive-behavioral therapy with cognitive-behavioral hypnotherapy on sexual satisfaction of women with fibromyalgia syndrome.
Methods: This clinical trial study was done on 9 women with fibromyalgia syndrome who referred to rheumatology clinic in Gorgan, northern Iran in 2020. The patients were randomly divided into three groups including cognitive-behavioral therapy, combination cognitive-behavioral hypnotherapy and control group. The treatments used were performed for 8 sessions separately for 2 groups of 3 people in Pars Tavan Comprehensive Center. Control group did not receive any intervention. A multidimensional sexual satisfaction questionnaire of Roshan 2014 was used to evaluate patients.
Results: Sexual satisfaction in post-test on both interventional group showed a significant improvement compared to control group (P<0.05). Cognitive-behavioral hypnotherapy with 59.38% was more effective than cognitive-behavioral therapy with 43.01 and also it was the same 2 month after follow up (P<0.05).
Conclusion: Combined therapy of cognitive-behavioral hypnotherapy increased sexual satisfaction in women with fibromyalgia syndrome more than cognitive-behavioral therapy.