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Background and Objective: Due to the increase of incidence of extrapulmonary tuberculosis in Iran, This study was conducted to determine the epidemiological pattern of extrapulmonary tuberculosis in the Mazandaran province, northern Iran. Methods: This descriptive-analytic study was carried out on medical record of 3313 tuberculosis patients in Mazandaran province, northern Iran during 2001-11. Age, gender, affected year, area and affected organ were gathered for each patient. Results: 843 (25.4%) of subjects were diagnosed with extrapulmonary tuberculosis. The incidence of extrapulmonary tuberculosis increased by 4% for every unit increase in incidence year (P<0.05). The mean age of patients with extrapulmonary tuberculosis was significantly less than patients with pulmonary tuberculosis (42.8±20.6 years vs. 48.7±21.2, P<0.05). Extrapulmonary tuberculosis was significantly higher in women (P<0.05). The chance of extrapulmonary tuberculosis in women was 1.7 times of men. Lymph node (33%) was the most common affected organ followed by pleura (18.9%) and bone (17.7%). Conclusion: The trend of incidence of extrapulmonary tuberculosis was ascending during 2001 to 2011. The most affected organ in extra pulmonary tuberculosis was lymph nodes.

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Background and Objective: Para-nonylphen as an environmental pollutant has weak estrogenic activity and causes oxidative stress in different organs including testis. This study was done to determine the protective effect of vitamin E on the para-nonylphenol induced-testicular toxicity in adult rats. Methods: In this experimental study, 24 Wistar rats were randomly allocated into four groups including control, vitamin E (100 mg/kg/day, orally), para-nonylphenol (250mg/kg/day, orally) and finally para-nonylphenol (250mg/kg/day, orally) plus vitamin E (100mg/kg/day, orally). After 56 days of treatment, removal of the right testis, tissue processing and staining with Heidenhain's Azan, the morphometric parameters of testicular tissue was evaluated using stereological method. Results: The mean volume of seminiferous tubules, height of the germinal epithelium, seminiferous tubules diameter, thickness of the basement membrane, number of spermatocyte, spermatid and sertoli cells significantly reduced in para nonylphenol group compared to the controls (P<0.05). These parameters were significantly increased in the para-nonylphenol plus vitamin E group compared to para nonylphenol group (P<0.05). In the histopathological examination, atrophy of seminiferous tubules, germinal epithelium vacuolation and epithelial disarrangement were observed in para nonylphenol group. Histopathological alterations reduced in para-nonylphenol plus vitamin E group compared to para nonylphenol group. Conclusion: Co-administration of vitamin E with para nonylphenol can prevent the adverse effects of para nonylphenol on the testicular tissue in adult rats.

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Background and Objective: The therapy of psychological problems in children and adolescents not only has medicinal aspects, but also it is really considered as prevention of psychological disorders. The most common childhood disorders that may be referred to mental health professionals is behavioral disorders. Among these, the most common is conduct disorder. This study was done to determine the efficacy of adolescent parent management training in conduct disorder symptoms and improve parents' parenting styles in 14-16 adolescent. Methods: In this clinical trial study, following the diagnosis disorder in 32 adolescent the subjects and their parents randomly divided into the intervention and control groups. Disease sign inventory (CSI-4) questionnaire, rabinson parenting style questionnaire and sanders educational package for adolescent were used in pre and post-test. Results: Conduct symptoms in post test significantly reduced after scores modification (P<0.05). Scores in authoritarian parenting style significantly increased while permissive and authoritative styles reduced in comparison with controls (P<0.05). Conclusion: Training parentings improve relationships between parents and children and in addition it is an effective intervention in the treatment of behavioral disorders in children and adolescents.

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Background and Objective: Vulvovaginal candidiasis or Candida vaginitis is a common fungal infection among adult women during reproductive ages and it is the second most frequent infection of the female genital tract. This study was carried out to determine of the prevalancy and species of vulvovaginal candidiasis and related clinical findings. Methods: This descriptive - analytical study was carried out on 400 women whom reffered to gynological center in Chabahar city in South-East of Iran during 2013. Vaginal samples were examined with direct microscopy and cultured on sabouraud dextrose agar and corn meal agar. Germ tube test and sugar assimilation test were carried out to differentiate the Candida species. The clinical findings including burning and itching during intercourse, burning with urination, foul-smelling vaginal discharge, vaginal deliveries, pH of the vagina, cervix appearance, consistency and color of vaginal in patients with vaginal discharge were recorded. Results: The prevalence of vulvovaginal candidiasis was 45.8%. Isolated candida species were candida albicans with 80.87% and Candida non-albicans with 19.13%. There was significant correlation between itching (85.52%) and burning during intercourse (67.87%), hypogastric pain (80.53%) with vulvovaginal candidiasis (P<0.05). 73 patients (39.9%) reported urinary burning. The most common affected by vulvovaginal candidiasis was with marriages age of 11-20 years old (P<0.05). Conclusion: The most common isolated species was candida albicans. The common clinical findings were burning, itching, smelly discharge, vaginal parity.

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Background and Objective: Rheumatoid arthritis is a chronic, inflammatory and systemic disease with peripheral, symmetric polyarthritis symptoms. Several genetic, environmental, and immunological factors contribute greatly to the disease pathogenesis. This study was done to evaluate the effect of anti-cyclic citrullinated peptide (anti - CCP) and rheumatoid factor on clinical disease activity index (CDAI) in the patients with rheumatoid arthritis. Methods: This prospective cohort study was done on 64 rheumatoid arthritis patients according to ACR criteria (1978) whom referred to Rheumatology Clinic of Hajar Hospital in Shahrekord, Iran. Patients were clinically examined for primary CDAI and tested for anti - CCP and rheumatoid factor in the prior and six months after the initiation of the study. Results: 81.3% and 74% of the patients had high titers of anti – CCP antibody and positive rheumatoid factor, respectively. A non-significant recudtion was observed in intensity of secondary clinical activity of the disease in compare to primary clinical activity in the patients with high antibody titer. Conclusion: This study indicated the important role of rheumatoid factor and anti- CCP antibody in the on time diagnosis of rheumatoid arthritis.

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Background and Objective: Parathyroid proteins involved in calcium homeostasis. With increasing age and other relevant factors, this hormone is not able to perform its role. Using recombinant parathyroid hormone prevent disease progression and effective in improvement of disease. This study was done to design and build the desired construct genes, cloning process and synthesis of soluble parathyroid hormone in E. coli. Methods: In this laboratory study, design and optimization sequence of the gene parathyroid hormone (PTH) was carried out for expression of soluble proteins in bacteria. The construct contining PTH gene (puc 57) transformed into bacteria and cultivation was done in SOB medium then Plasmid extraction was performed. Fragment encoding the PTH was isolated by digestion of the cloning vector and ligate to expression vector (PET-32a). Subcloning process followed by induction with IPTG 1mM. The recombinant parathyroid hormon was expressed in bacteria, subsequently. Results: After enzymatic digestion, the fragment encoding the protein of interest was properly localized. The process was confirmed by polymerase chain reaction (PCR). Following performing a transformation, induction process performed by IPTG with final concentration 1mM that caused the soluble parathyroid proteins to be expressed in bacteria and the process was confirmed by Western blot technique. Conclusion: Protein expression in bacteria due to its rapid growth and the need to inexpensive medium is cost-effective. Soluble recombinant protein expression reduces downstream of recombinant protein production.

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Background and Objective: Sodium Arsenite is an environmental pollutant which can generate free radicals causing tissue damage. This study was done to evaluate the effect of Green Tea (GTE), as a strong antioxidant, on kidney tissue in mice treated with Sodium Arsenite. Methods: In this experimental study 24 adult male NMRI mice were randomly allocated into four groups including: control, GTE (100mg/kg/day), Sodium Arsenite (5mg/kg/day) and Sodium Arsenite + GTE, for 34 days, orally. Animals were scarified and left kidney was taken out, fixed, sectioned, processed and stained using Heidenhain'azan method. Using stereological technique the total volume of kidney, volume of cortex, medulla, proximal and distal tubule, renal corpuscle, gelomerelus, tuft and capillary, membrane and space of Bowman's capsule and length of proximal and distal tubule were determined. Creatinine, BUN and MDA serum samples were measured. Results: The mean of total volume of cortex, proximal tubule, distal tubule, renal corpuscle and gelomerolus, taft, Bowman's capsule space, size of epithelium and lumen of proximal and distal tubule were significantly reduced in Sodium Arsenite group compared to control (P<0.05). These parameters were significantly increased in the Sodium Arsenite + GTE group in comparison with Sodium Arsenite group (P<0.05). The creatinine, Blood urea nitrogen (BUN) and MDA were significantly increased in the Sodium Arsenite group in compared to the control group (P<0.05). These parameters were significantly reduced in the Sodium Arsenite + GTE group in comparison with Sodium Arsenite group (P<0.05). Conclusion: Green tea has a protective role in Sodium Arsenite induced nephrotoxicity.

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Background and Objective: Bisphenol A (BPA) is an endocrine disruptor chemical and as an environmental pollutant is able to generate free radicals causing tissue damage. This study was done to investigate the effect of Nigella sativa oil against BPA induced toxicity on the tissue of male NMRI mice kidney by stereological method.

Methods: In this experimental study 24 adult male NMRI mice (32±3 g) were randomly allocated into control, BPA (200 mg/kg/day), BPA (200 mg/kg/day) plus Nigella sativa oil (5 ml/kg/day) and Nigella sativa oil (5 ml/kg/day) groups and treated for 5 weeks, orally. At the end, animals were sacrificed, their left kidneys were removed, fixed, sectioned, processed and stained with Heidenhain' azan staining method. Then, the kidney tissue sections were evaluated using stereological method and serum malondialdehyde (MDA) level was also measured.

Results: The total weight and volume of kidney, volume of cortex, volume of proximal and distal tubules and volume of their lumen, volume of interstitial tissue, volume of glomeruli, tuft, as well as serum MDA level significantly increased in BPA treated group compared to the controls (P<0.05). These parameters were significantly reduced in BPA plus Nigella sativa oil group compared to BPA ones (P<0.05).

Conclusion: This study revealed that Nigella sativa oil can reduce the oxidative stress toxicity induced by BPA in the mice renal tissue.

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Background and Objective: The electromagnetic field producer sets in daily life causes concerns about the adverse effects of such waves on human health. This study was done to evaluate the effect of cell phones microwaves on histologic structures of some visceral organs in rat.

Methods: In this experimental study, 80 immature Wistar male rats with weight of 100-140 gram and 5 to 6 weeks age were randomly allocated into 3 experimental groups and one control group. The experimental rats were exposed to cell phones microwaves 5 hours a day for 1, 2 and 3 months. The control group received no radiation. After the experimental period rats were sacrificed and the appropriate tissues of the lung, heart, liver, brain and pancreas were prepared. Sections in 5 µm thicknesses were stained by hematoxylin and eosin and studied microscopically.

Results: Histological changes including edema, inflammatory cell infiltration and cell degeneration in the lung and mild degeneration and coagulation necrosis of the myocardial cells in the heart were observed. Histopthological examination of the liver revealed dilation of central veins and sinusoids, vacuolization of hepatocytes and mononuclear inflammatory cell infiltration. Limited changes were observed in pancreas and brain. Histological changes were increased in the groups that were exposed longer period of time to radiation.

Conclusion: This study indicated that the harmful effect of cell phones radiation on rat tissues depending on the duration of exposure.

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Background and Objective: A brief and short duration episode of ischemia is recorded in ischemic preconditioning (IPC). This latter condition provides a status in which large region of heart is protected when prolonged ischemia occurred. Levothyroxine play a protective role in IPC induction, and simultaneously with stress oxidative. This study was conducted to determine the protective effect of levothyroxine with oxidative stress reduction mechanism in ischemic preconditioning model in rat heart.
Methods: This experimental study was performed on 30 male Wistar rats in three groups of 10, as follows. In the reperfusion ischaemia group (IR), the heart of the animal was placed in a Langendorff apparatus. In the ischemic preconditioning group (IPC), prior to major ischemia, was exposed to 4 periods of 5-minute ischemia with reperfusion. In the intraperitoneally administered group, levothyroxine at a dose of 25 microgram per 100 g of body weight, the heart was exposed to reperfusion ischemia. The area of infarct and the level of malondialdehyde in the heart tissue were measured.
Results: The volume of Infarcted region in IR and IPC groups was 26.55 and 11.11 respectively. The same index for the Levothyroxine receiver was 12.56. Based on these findings it was demonstrated that Levothyroxine injection reduced the Infarcted region significantly similar with IPC (P<0.05). The MDA Levels in IR and IPC were 1328 and 777, respectively and in Levothyroxine group it was determined as 762. The size of Infarcted region in both IPC and treated with Levothyroxine groups significantly reduced in compared to IR group (P<0.05).
Conclusion: Injection of levothyroxine with ischemic preconditioning reduced the effect of reperfusion maladaptive ischemia in rat heart.

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Background and Objective: Oxidative stress plays an important role in the pathogenesis of some diseases such as atherosclerosis and doing high intensity training may enhance oxidative stress. This study was done to evaluate the effect of eight weeks resistance training on malondialdehyd, total, antioxidant capacity, liver enzymes and lipid profile in overweight and obese women.
Methods: In this quasi-experimental study, 16 overweight and obese women were non-randomly divided into intervention (n=9) and control (n=7) groups. The resistance training included the resistance training (with intensity of 50-80% one repetition maximum) that lasted for 8 weeks and 3 sessions per week. Every session lasted for 60 minutes. Malondialdehyd, total antioxidant capacity, liver enzymes and lipid profile for each subject was measured.
Results: The eight weeks resistance training significantly increased total antioxidant capacity high density lipoprotein and triglyceride in interventional group in compared to controls (p<0.05). The eight weeks resistance training significantly reduced alanine aminotransferase in comparison with control group (p<0.05).
Conclusion: Eight weeks resistance training by reducing malondialdehyd and increasing total antioxidant capacity may reduce the risk of atherosclerosis disease and improving cardiovascular health.

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Background and Objective: Chronic itching reduces the quality of life of patients undergoing hemodialysis. This study was done to determine the effect of chronic itching on the quality of life of patients under hemodialysis in north of Iran.

Methods: In this descriptive-analytical study, 111 patients with mean age of 58.36±12.7 years were randomly selected from hemodialysis centers of Golestan province from May to December 2017. Demographic data, quality of life (Itchy QOL questionnaire), Xerosis, pruritus intensity (Balaskas 1998), and laboratory tests including calcium, phosphorus, alkaline phosphatase, parathyroid hormone, blood urea nitrogen, creatinine, hemoglobin and hematocrit were evaluated.

Results: The mean score of itching severity and overall quality of life was 29.27±7.46 and 41.4±10.44, respectively. There was a significant correlation between the severity of itching and the overall score of patients' quality of life (P<0.05). Correlation between severity of pruritus with symptom dimension, functional dimension and emotional dimension was significant (P<0.05). There was a significant correlation between severity of itching and Xerosis and serum calcium level (P<0.05). There was a significant correlation between Xerosis and calcium level with increased itching (P<0.05).

Conclusion: Itching reduced the quality of life in hemodialysis patients in north of Iran.

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Background and Objective: Type 2 diabetes is a chronic disease that associated with increased serum glucose and insulin function impairment. Exercise training and saffron supplement are known as two effective factors in the prevention of the complications of type 2 diabetes. The present study aimed to evaluate the impact of eight weeks of aerobic and resistance training with the consumption of saffron aqueous extract on malondialdehyde and glutathione peroxidase in men with type 2 diabetes.
Methods: In this clinical trial study, 36 men suffering from type 2 diabetes were randomly assigned into six groups: placebo, aerobic training, aerobic training with supplement consumption, resistance training, and resistance training with supplement consumption. Aerobic training was performed at 50-70% of maximal heart rate, and the resistance training was performed at 65-70% of the maximum replication for eight weeks. The saffron supplement was consumed at the dosage of 3 mg day-1. The concentration of malondialdehyde and glutathione peroxidase was measured before and after the trial after the 12-hour fasting period.
Results: Level of malondialdehyde significantly reduced in placebo and aerobic training with supplement prior to intervention (P<0.05). Level of glutathione peroxidase were significantly increased in aerobic training with supplement (P<0.05), resistance training (P<0.05) and resistance training with supplement (P<0.05) groups after intervention.
Conclusion: Aerobic and resistance training and their supplementation with saffron consumption can be regarded as an effective method to improve the peroxidase and antioxidant balance.

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Background and Objective: Cardiovascular diseases and heart failure are major diseases in developed countries. Stem cells showed specific features to play an important role in heart disease treatment. One of the most common compounds has been used to induce differentiation of stem cells into cardiomyocyte is 5-Azacytidine. Medium contents of cell culture such as different glucose concentrations also influence on morphology and function of final differentiated cells. This study was done to evaluate the effect of glucose on improvement of BM-MSC differentiation into cardiomyocyte - like cells.
Methods: In this experimental study, effect of two different glucose concentrations (5 and 25mM) on the mesenchymal stem cells differentiation (MSCs) to cardiomyocytes during 21 days was evaluated. Bone marrow MSCs (BM MSCs) seeded in differentiation medium which treated with 5-aza and 5 & 25mM glucose concentrations. In next step, total RNA was extracted and cDNA synthesis was carried out. Finally, quantitative polymerase chain reaction (Q-PCR) was done to determine level of cardiac-specific markers during differentiation process including Connexin43, α-cardiac actin, TroponinT and TroponinI.
Results: Level of cardiac-specific markers during differentiation of mesenchymal stem cells to cardiomyocyte including Connexin43, α-cardiac actin, TroponinT and TroponinI in 5 and 25 mM of glucose concentration was diferent, but this diference was not significant.
Conclusion: Our results showed that two concentrations of glucose (5, 25mM) have no remarkable effect on the expression of cardiac markers during differentiation of bone marrow mesenchymal stem cells to cardiomyocyte.

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Background and Objective: Todays, coronary artery disease is one of the most important health issues. Antioxidants are the agents that can play important role in reducing cardiovascular diseases. The present study was done to determine the effect of resveratrol supplementation during rehabilitation exercises training on systemic inflammation factors in patients after coronary artery bypass surgery.
Methods: This clinical trial study was done on 40 patients after coronary artery bypass surgery in the heart rehabilitation center of Farshchian cardiovascular specialist hospital in Hamadan, Iran during 2016. Patients randomly assigned into four groups including control (Con; n=10), resveratrol supplementation (RS; n=10), rehabilitation exercise training (RXT; n=10), and resveratrol supplements-cardiac rehabilitation exercise training (REX; n=10). Rehabilitation exercise training was done in nonconsecutive three sessions for eight weeks in the form of endurance training at 50-70% HRmax for 15-20 min, and resistance training at 20-50 one-repetition maximum (1RM). The number of repetitions was 8-15 reps, where done based on the capacity and ability of the subject, while the subjects in supplement groups consumed daily 400 mg of resveratrol. Blood sample was done before and 48 hours after exercise training and supplementation, and concentrations of Tumor necrosis factor alpha (TNFα), Interleukin- 6 (IL-6), Interleukin 1 beta (IL-1β) and C-reactive protein (CRP) were measured in the plasma.
Results: CRP, TNF-alpha and IL-1beta and IL-6 were significantly reduced in resveratrol supplements-cardiac rehabilitation exercise training group in compared to control, resveratrol supplementation and rehabilitation exercise training groups (P˂0.05).
Conclusion: This study showed that combination of consuming resveratrol with rehabilitation exercise training in reducing some inflammatory factors was evaluated selectively, more effective than rehabilitation exercise training and resveratrol supplementation alone.

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Background and Objective: Multiple sclerosis (MS) is one of the most common progressive neurological diseases affecting the motor pathways leading to muscle fatigue. This study was done to evaluate the effect of eight weeks of aquatic exercises on fatigue, balance and functional training in male patients with multiple sclerosis.
Methods: This clinical trial study was done on 15 men with multiple sclerosis in Zahedan, south-east of Iran. The subjects selected by available and purposeful sampling method participated in research. After primary screening and reconnaissance person of bona fide, subjects randomly divided into intervention group (n=8) with average age 42.62±6.67 height 171.87±2.47 weight 69.62±12.39 and control group (n=7) with average age 30.28±7.11, height 171.57±8.05 weight 66.68±17.26. During study the patients used and follow medicinal drugs according to prescription. Subjects in interventional group were received aquatic exercises program. Aquatic exercises program consisted of 8 weeks, 3 sessions per week. The level of fatigue, balance and functional movement respectively evaluated with fatigue assessment battery for MS, Y balance and side hop jump tests.
Results: The mean of functional movement was significantly increased in interventional group in comparison with controls (P<0.05). The mean of fatigue was significantly reduced in interventional group compared to controls (P<0.05).
Conclusion: Eight weeks of aquatic exercises improves functional movement and reduce fatigue in male patients with multiple sclerosis.

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Background and Objective: Type 1 diabetes (T1D) is highly prevalent in the group of autoimmune and inflammatory patients. Tumor necrosis factor-alpha (TNF-a) and interleukin-10 (IL-10) plays an important role in regulating complex interactions between pancreatic beta cells and immune cells in the development of T1D. This study was performed to determine the simultaneous effect of resistance training and endothelial progenitor cell injection on blood glucose levels and protein expression of proinflammatory factors TNF-a and IL-10 in muscle tissue of streptozotocin (STZ) induced diabetic male rats.
Methods: In this experimental study, 36 male Wistar rats weighing approximately 200±20 g and six weeks old were randomly divided into six groups. Induction of diabetes was performed by intraperitoneal injection of STZ at a dose of 45 mg/kg body weight. Groups included diabetes + stem cell injection + resistance training group, diabetes + resistance training group, diabetes + stem cell injection group, control diabetic group to control the passage of time, and healthy basal and diabetic groups for defaults. Exercises were performed for 17 sessions of resistance training, including climbing ladders with increasing weight three days a week in the same laboratory conditions. Endothelial progenitor cells were cultured by femoral bone marrow aspiration and culture and then injection into the tail vein. 68 hours after the last training session, blood glucose levels were assessed by ELISA and the expression of TNF-a and IL-10 protein in muscle tissue was assessed by Western blotting.
Results: Endothelial stem cell injection, resistance training and resistance training with the simultaneous injection of endothelial stem cells significantly increased the anti-inflammatory factor IL-10 in the skeletal muscle tissue of diabetic rats in compared to control group (P<0.05). Expression of the anti-inflammatory factor IL-10 in the skeletal muscle tissue was significantly increased in resistance training plus the simultaneous injection of endothelial stem cells group in compared to injection of stem cells and resistance training groups (P<0.05). Glucose concentration in the skeletal muscle tissue was significantly reduced in resistance training plus the simultaneous injection of endothelial stem cells group in compared to injection of stem cells and resistance training groups (P<0.05).
Conclusion: It seems that 17 sessions of resistance training reduces blood glucose level and improves inflammatory conditions in response to an increase in IL-10 and a decrease in TNF-a in a group of diabetic rats with resistance training and simultaneous injection of endothelial progenitor cells in diabetic male rats.

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Background and Objective: Spirulina (Spirulina platensis) has numerous nutritional and therapeutic benefits. This experimental study aimed to investigate the effect of spirulina on changes in the levels of liver enzymes of male BALB/c mice exposed to a high dose of acetaminophen.
Methods: In this experimental study, 42 adult male BALB/c mice were divided into seven groups of six. The toxic dose of acetaminophen 600 mg/kg body weight was considered. The control group received only a standard diet and water. The sham group was gavaged with saline solution. The third to seventh groups were treated as: acetaminophen; spirulina 600 mg/kg/bw, spirulina 300 mg/kg/bw, spirulina 600 mg/kg/bw + acetaminophen, and spirulina 300 mg/kg/bw + acetaminophen, respectively. In all groups, mice were treated with acetaminophen and spirulina powder by gavage for 14 consecutive days. Twenty-four hours after receiving the last dose of medication and deprivation of food (the animals still had access to water), the animals were anesthetized and blood samples were taken from the heart. Activity of liver enzymes including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) was measured by spectrophotometry. Protein concentration was determined by the Lowry method. Catalase activity was assessed using hydrogen peroxide. The amount of malondialdehyde was measured and the total antioxidant capacity was determined by FRAP method by reducing ferric to ferro ions.
Results: The levels of serum transaminases (ALT, AST, ALP) as well as the level of total antioxidant capacity and malondialdehyde of the acetaminophen-treated group increased significantly compared to the control group (P<0.05). The levels of these enzymes in the group treated with S. platensis 300 mg/kg/bw + acetaminophen decreased significantly compared to the group treated with acetaminophen (P<0.05). Catalase activity in the acetaminophen group was significantly decreased compared to the control group (P<0.05).In the group of S. platensis 300 mg/kg/bw + acetaminophen, catalase activity increased significantly compared to the acetaminophen group (P<0.05). The results of experiments in two groups of spirulina and acetaminophen showed that the active ingredients of the algae at a dose of 300 worked better than 600 mg per kg of body weight in response to oxidative stress.
Conclusion: Consuming 300 mg/kg of S. platensis along with a near toxic dose of acetaminophen increases resistance to oxidative stress and injuries caused by drug poisoning by affecting the activity of enzymes and the antioxidant defense system.
 

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Renal cavernous hemangioma is a rare benign tumor. This case report describes a 44-year-old male who was incidentally found to have a renal mass during an abdominal and pelvic ultrasound. The patient's abdominal ultrasound revealed a mass, which was further evaluated with a CT scan. The CT findings suggested renal cell carcinoma. Suspecting malignancy, the patient underwent radical nephrectomy. Histopathological and immunohistochemical examinations ultimately diagnosed the mass as a cavernous hemangioma. Despite its benign nature, the patient was followed up with a control ultrasound three months post-surgery. This case is presented due to the significant clinical and radiological resemblance of this tumor to renal carcinomas, highlighting the importance of considering benign tumors in differential diagnoses.

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Background and Objective: Methamphetamine is a highly addictive drug associated with severe psychosocial consequences and is extensively abused. This study aimed to determine the effects of four weeks of aerobic exercise and berberine supplementation on the expression of dopamine 5 receptor and poly (adenosin diphosphat [ADP]-ribose polymerase (PARP) genes in the heart tissue of methamphetamine-exposed rats.
Methods: In this experimental study, 30 female Wistar rats were randomly allocated into five groups of six: Control, methamphetamine, methamphetamine + aerobic exercise, methamphetamine + berberine, and methamphetamine + aerobic exercise + berberine. Intraperitoneal injections of methamphetamine (10 mg/kg) and aerobic exercise and berberine consumption (100 mg/kg) were administered for 4 weeks during the withdrawal period. The expression levels of dopamine 5 receptor and PARP genes was measured using real-time polymerase chain reaction (PCR).
Results: There was no significant difference in PARP gene expression between the methamphetamine group (1.02±0.65) and the control group (1.02±0.24). Similarly, there was no significant difference in dopamine 5 receptor gene expression between the methamphetamine group (5.74±4.94) and the control group (4.76±2.63). The expression levels of PARP and dopamine 5 receptor genes following exercise (1.01±0.55 and 4.30±1.96, respectively), berberine supplementation (0.61±0.25 and 2.97±1.45, respectively), and the combined intervention (0.67±0.30 and 3.43±1.87, respectively) showed no significant differences between the groups.
Conclusion: Short-term methamphetamine induction did not induce significant changes in the expression of dopamine 5 receptor and PARP genes in the hearts of methamphetamine-exposed rats.