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Showing 81 results for Mat

Alavi Sm (md), Moola K (md),
Volume 12, Issue 3 (10-2010)
Abstract

Background and Objective: The incidence of infections is one of the most disturbing problems in the management of patients with systemic lupus erythematosus (SLE). The aim of this study was to describe the role of tuberculosis (TB) as a cause of fever in SLE patients. Materials and Methods: In this descriptive study 103 SLE patients enrolled in Ahvaz, South-West of Iran during 2000 - 06. Patients were diagnosed according to American College of Rheumatology criteria (at least 4 of 11 criteria). Diagnosis of tuberculosis was based on Iranian National Program against TB criteria. The infection free patients were given corticosteroid therapy. Results: In this study 20 patients did not follow the complete cycle and finally 83 patients were established as sample population of this study. Mean age of patients was 22.2±10 years, female to male ratio was 9.2:1, mean duration of treatment was12±3.2 months and mean of daily dose of prednisolone was 28.2±13 mg.From total of patients, 8 (9.6%) had active tuberculosis. five patients had pulmonary and three with other type of TB, respectively. One of the above eight patients eventually died due to SLE/TB. Conclusion: Tuberculosis is one of the important causes of fever among patients with SLE under treatment of corticosteroid. In approaching febrile SLE patient TB should always be considered as a treat.
Sedighy S, Sadani S, Rezaii Yazdi Z, Hatef Mr, Tavakoli Afshar J, Azarpazhoh Mr, Aghai M, Esmaeili H,
Volume 13, Issue 1 (3-2011)
Abstract

Background and Objective: Systemic lupus erythematosus (SLE) is an inflammatory multi-system disease with an unknown origin. In patients with lupus disease cardiovascular events is an important cause of mortality and morbidity. This study carried out to measurement of high sensitivity C –reactive protein (HsCRP) and homocysteine in patients with SLE and their relation with diseases activity and cardiovascular risk factors.

Materials and Methods: This case control study carried out on 60 patients (55 females and 5 males) with lupus disease which referred to Clinical Research Center of Rheumatology, Mashhad, Iran and 30 controls (26 females and 4 males) during 2007-08. Information of subjects were gathered using SLEDAI questionare. HsCRP and homocysteine of subjects were measured. The level of low density lipoprotein (LDL), Triglycerid, hypertension and Body mass index (BMI) was assessed. Systemic lupus erythematosus activity was assessed by using SLEDAI so that if the score was higher than 10, lupus was called as active disease.

Results: Mean age was 28.8±10.3 and 33.8±9.13 years in SLE and control groups respectively. The mean of HsCRP in SLE patients were 3±2.42 mg/dl versus in controls were 1.58±2.1. The serum level of homocysteine were 12.3±1.93 µmol/L and 24±8.13 µmol/L in SLE patients and controls (P<0.001). Mean disease activity was 15.37. There was no any associtation between homocysteine and HsCRP and disease activity. LDL, Triglycerid, hypertension had significant association with homocystein (P<0.05). BMI and Triglycerid had significant association with HsCRP (P<0.05).

Conclusion: This study showed that there is no linear significant corrolation between homocysteine, HsCRP and disease activity, but there is significant corrolation between increase of homocysteine and HsCRP and cardiovascular risk factors.


Ghaffary Mr, Airemlou H, Taghizadieh A,
Volume 13, Issue 1 (3-2011)
Abstract

Background and Objective: Critical illness diaphragmatic neuromyopathy are significant  causes of weakness, morbidity and prolong mechanical ventilation among critically ill patients under mechanical ventilation. It is important determine the true initial time of neuromyopathic changes associated with critically ventilated patients. Based on new electrodiagnostic studies, electrophysiological studies of diaphragm and phrenic nerve, as an important muscle and nerve in ventilation, compared with other evaluating methods, have specific importance. This study was done to evaluate of the diaphragmatic myopathy onset time among mechanically ventilated patients using electrophysiological method.

Materials and Methods: This descripvtive study was performed on 56 mechanically ventilated patients in intensive care unit without primary neuromuscular disease in Tabriz Imam Khomeini hospital in West of Iran between 2004-06 years. Electromyography (EMG) and nerve conduction velocity test were performed in the 4th and then in 4 days intervals.

Results: In 56 patients EMG and NCV performed at 4 and 8 days after mechanical ventilation, none of them had any evidence in favor of diaphragmatic myopathy. During the course of study, EMG were done on 24 patients in 12th days , that in three of them (12.5%), mild myopathy were reported. From 18 patients, considered in 16th days, only five (31.25%) of them showed mild myopathy. From 10 (100%) reminder patients, in 20th day, all of them had mild to moderate myopathy.

Conclusion: According to these results, minimum duration of the diaphragmatic weakness onset time in mechanically ventilated patients with diverse causes in general critical care ward were 12 days and increased with prolonged time of mechanical ventilation.


Amiriani T, Besharat S, Semnani Sh, Joshaghani Hr, Roshandel Ghr, Keshtkar Aa, Kiaii Mr, Mirkarimi Hs, Hashemi-Nasab Sz, Zendeh-Bad As,
Volume 13, Issue 1 (3-2011)
Abstract

Background and Objective: Celiac is a hereditary disease presented with chronic inflammation of small intestine. Several studies supposed a relationship between Celiac disease and Inflammatory Bowel Disease (IBD). Tissue trans-glutaminase antibody is one of the best serological markers in Celiac disease. This study was designed to evaluate the association of Celiac and IBD using tissue trans-glutaminase antibody.

Materials and Methods: In this descriptive study 127 confirmed IBD patients who were referred by gastroentrologists 2005-08 enrolled into the study. A questionnaire was completed and tissue trans-glutaminase antibody was evaluated with ELISA method with a Cut-off=12 U/ml.

Results: Among 127 referred patients, serum samples of 102 patients were collected. Mean±SD of age was 36.17±15.2 years and 48% were males. Ulcerative colitis, Crohn’s disease and other colitis were observed in 76 (74.5%), 7 (6.9%) and 19 (18.6%) of patients, respectively. Tissue trans-glutaminase antibody was positive (19.8 U/L) in one 46-years-old male patient with ulcerative colitis.

Conclusion: Tissue trans-glutaminase antibody titer was not significantly different between IBD patients and controls, thus it seems not appropriate to suggest as one of the routine tests in IBD patients.


Shahraki A (phd), Ghahghaei A (phd), Zakeri Z (phd),
Volume 13, Issue 3 (10-2011)
Abstract

L-glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). It contribute in various physiological conditions such as brain development, synaptic plasticity, memory and learning. However, increasing of the extracellular glutamate concentration and overactivation of glutamate receptors in particular ionotropic subtypes leads to excitotoxicity which is the fundamental pathological pathway of neuronal injury. Due to lack of extracellular enzymatic destruction, the removal of released glutamate is achieved through the excitatory amino acid transporters (EAATs) which are distributed in glia that tightly surround the synaptic clefts, as well as in neurons. EAATs which known as Na+-dependent high-affinity glutamate transporters are the main responsible for maintaining extracellular glutamate concentration below excitotoxic levels. Moreover another membrane transporters regulating the flux of glutamate in different areas of the CNS. This system is cystine-glutamate exchanger (XCG-) that is Na+-independent system. Dysfunction of EAATs has been implicated in both acute insults e.g. stroke, trauma and chronic neurological and neuropsychiatric disorders e.g. amyotrophic lateral sclerosis, epilepsy, schizophrenia and Alzheimer's disease. Therefore, the purpose of this review article is to explain the pathway of glutamate biosynthesis, its release into CNS, discribing and elaborating Glutamate transporters, activites and their role in excitoxcity in CNS.
Ghaffari E (ma), Shahi As (ma), Ozouni Davaji Rb (ma), Rostami R (ma),
Volume 13, Issue 3 (10-2011)
Abstract

Background and Objective: Normal psychological behaviour is one of the general concept of health. This study was carried out to evalute psychological disorders among inhabint residing in poor social district of Gorgan, Iran. Materials and Methods: This cross-sectional study was done on 376 subjects (188 males and 188 females) with simple random sampling method. Data were gathered using the general health questionnaire (GHQ-28). Data was analyzed by SPSS-16, Kruskal–Wallis and Pearson tests. Results: The prevalence of psychological disorders was 37% (33.5% in men, 40.4% in women), depression was 24.45% (22.5% in men and 26.4% in women) and anxiety was 31.6% (31.2% in men, 32% in women). Social affairs disorder 21% (19.2% in men, 22.7% in women) and psychosomatic disorders in 28.5% (22% of men, 35% of women). The relationship between psychological disorder with economic level and family size was significant (P<0.05). Conclusion: This study showed that 37% of inhabint residing in poor social district of Gorgan, Northern Iran had psychological disorders.
Kabiri N (msc), Asgary S (phd),
Volume 13, Issue 4 (12-2011)
Abstract

Background and Objective: Elevated levels of inflammation markers including white blood cell, platelet, serum fibrinogen and CRP are associated with prognosis in patients with coronary artery diseases. This study was done to determine the effect of hydroalcoholic extracts of Amaranthus caudatus l on Inflammation markers level in Hypercholesterolemic Rabbits. Materials and Methods: In this experimental study, 20 male Rabbits were allocated into four groups of five each: Group I Normal diet(75 days) Group II Hypercholesterolemic diet (75 days) Group III and IV Hypercholesterolemic diet (45 days) followed by Normal diet and Normal diet with hydroalcoholic extracts Amaranthus caudatus l., respectively for an additional 30 days(Regression period). Blood samples were collected from rabbits before and after 45 days and 75 days of respective diet regimen. The level of White Blood cell, platelet, serum fibrinogen and CRP were measured. Data analyzed by using SPSS-13 and one-way ANOVA‌ test. Results: CRP in treatment group reduced from 8.14±4.5 mg/l to 17.8±4.6 mg/l in hypercholesterolemic animals (group II) (P<0.05). WBC count was 20820±8692 and 42366±17048 in treatment and hypercholesterolemic animals, respectively (P<0.05). Platelet and fibrinogen concentration was reduced in treatment group 502600±35725 and 208±24 mg/dl, respectively in comparison with hypercholesterolemic animals 638000±59774 and 299±46 mg/dl, respectively. These differences were significant (P<0.05). Conclusion: This study showed that hydroalcoholic extracts of Amaranthus caudatus l reduces inflammatory markers in hypercholesterolemic rabbits.
Daneshfard K (phd), Shiravand S (ma),
Volume 14, Issue 2 (6-2012)
Abstract

Background and Objective: Budget reforming and distribution of source is considered as one of economic bases of health and treatment. In the ministry of health, performance based budgeting has been performed since 2000. This study was done to identify barriers of operational treatment budget in Islamic Republic of Iran, ministry of health and medical education. Materials and Methods: In this descriptive study, data were gathered by questionairs to identify the barriers in six parts including: human resource, financial management system, financial information system organization structure, performance measurement system and legal necessities during 2007. The questionnaire were distributed among 80 executive staffs whome were responsible to perform operational budgeting plan. Data were analyzed using SPSS-16, fisher's exact test, Karl Pearson, Spearman correlation coefficient tests and Entropy criterion. Results: Disorder in commitment accontity statistical aconite system (0.1464), financial information system, weakening of quantity and proper index (0.1442) for estimating performance program performance measurement system were identified as major barriers. In organizational structure, assignment of authorities and responsiblies for managers and expert were identified as the most priorities (0.1447) of weakness of exact cost controlling system (0.1450) allocated the most rating in the financial management system. Staff resistance (01449) was with high rating in human resource dimension. weakness of rules and internal guidelines for establishment of mentioned budgeting the highest rate in legal barriers. Conclusion: This study indicated that there is corrolation between financial information, performance measurement, financial management systems, organizational structure human resource with barriers of budgeting establishment.
Mehrabadi S, Makvand Hosseini Sh, Miladi Gorji H , Nikfarjam Haft Asia M ,
Volume 14, Issue 3 (10-2012)
Abstract

Background and Objective: Post-traumatic stress disorder (PTSD) impairs spatial learning and memory. Desmopressin acetate ameliorates the cognitive deficits induced by electroconvulsive shock. This study was designed to evaluate the protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in rats. Materials and Methods: In this experimental study twenty one male Wistar rats were used. Animals were trained for 5 consecutive days in Morris water maze and then were randomly assigned in three groups (Vehicle + Sham, Saline + PTSD and Desmopressin acetate + PTSD) and tested in a probe 60 sec in 24h after the last acquisition trial. The groups of PTSD+Desmopressin acetate rats and vehicle+sham, saline+PTSD were injected Desmopressin acetate (10 micro gr/kg body weight) and saline (IP), respectively. Injections performed ten minute prior to PTSD and spatial memory was tested ten minutes later. Data were analyzed using SPSS-16, One-Way ANOVA and Tukey tests. Results: The platform location latency of the Desmopressin acetate+PTSD group was significantly shorter (4.24 sec) than the control group (P<0.05) and also, had significantly smaller average proximity values (33.87 cm) compared to the saline+PTSD group (P<0.05). Desmopressin acetate + PTSD spent significantly more time (21.65%) in the target zone (P<0.05). Conclusion: This study indicated that Desmopressin acetate blocks the ability of PTSD to impair spatial memory retention.
Mohseni Ra , Pakzad H,
Volume 14, Issue 3 (10-2012)
Abstract

Background and Objective: The child mortality is a index of development and plays an important role in determination of population growth. This study was done to determine the effect of sociol-economical conditions on mortality rate of under 5 years children, Khuzestan- Iran. Materials and Methods: This descriptive study was done on 372 women aged. 20-48 years with at least one child under 5 years whome were admitted to the health centers in urban and rural area of gotvand town in Khuzestan province, Iran during 2004. Individuals questionnaires included variables such as mortality, demographic, economic and social index were completed for each subject. Data were analyzed using SPSS-17, ANOVA, Chi-Square and Pearson’s correlation coefficient tests. Results: Providing maternal health care during pregnancy and up-grading occupational status of parents significantly reduced child mortality rate (P<0.05). Child mortality rate increased in mothers of <18 and >35 years (P<0.05) and parents desire to have male infant (P<0.05). Conclusion: This study showed that up-grading occupational status of parents, maternal health care and maternal age and desire to have male infant play important role on the child mortality rate in Khuzestan province in south west of Iran.
Farhud Dd , Afrooz Ga , Nosrati F,
Volume 14, Issue 3 (10-2012)
Abstract

Background and Objective: Down syndrome is a genetic disorder due to trisomy of 21 chromosome, which mainly is manifested by moderate to severe mental problems, including physical, sensory and motor symptoms. This study was done to determine the related factors associated with the birth of children with Down syndrome. Materials and Methods: This cross-sectional study was carried out on 913 mothers with children or fetuses of Down syndrome who were referred to genetic counseling clinics in Tehran, Iran during 2011. Diagnosis of Down syndrome confirmed by the chromosomes culture. Maternal age, maternal age at menarche, parents interfamilial marriage, maternal blood group, the number of abortions and children, collected through the questionnaires. Results: Out of 913 affected children and fetuses with Down syndrome, 420 (46%) and 493 (54%) were female and males respectively. 1.17 considered to be The male/female ratio. 32.4% of mothers were in 25-30 years of age and 42% of parants had interfamilial marriages. The abortion in mothers varied from lack of ahortion (96.7%) up to 5 repetitive abortion (0.1%). The number of children in families with affected subject consisted of 1 (15.1%), 4 (16.5%) and 11-13 (1.3%). Conclusion: This study showed that Down syndrome infants are mostly born with the mothers of 25-30 years age.
Mirshekar M, Abrari K, Goudarzi I, Rashidy-Pour A ,
Volume 15, Issue 1 (3-2013)
Abstract

Background and Objective: Post-traumatic stress disorder (PTSD) is an anxiety, which is induced by exposure to life-threatening trauma and produces memory dysfunctions. This study was done to evaluate the effect of β-estradiol on traumatic memory after post-traumatic stress disorder induced by modified single-prolonged stress model in male rats. Materials and Methods: This experimental study was done on 70 male Wistar rats, weighted 200-250 grams. Initially 30 rats randomly allocated into control, shock and single prolonged stress accompanied shock (SPS&S). In SPS&S group immobilized for 2h, followed immediately with a 20 min forced swim conducted in a cylindrical filled with water. After recuperating for 15 min, animals anesthetized with ether. After 30 min recovery, stressed rats placed in the conditioned fear system (CFS). They received one 1mA, 4 second electric foot shock and remained in the chamber for another 60 second before being returned to their home cages. Shock group: Animals placed in CFS and only received the same shock as previous experiment. Naive group: Animals were removed from their home cages and exposed to chamber without receiving any foot shock. 1, 2 and 3 week later, animals in all groups were re-exposed to the shock chamber for 3 min, in order to examine conditioned fear response. In the second experiment rats were injected with β-estradiol (90 µg/kg), one and two week after training. Date were analyzed using SPSS-16, ANOVA and LSD tests. Results: SPS&S significantly induced freezing response (traumatic memory) compared with controls and shock groups (P<0.05) following three weeks. This response significantly reduced due to repetitive injection of β-estradiol in rats (P<0.05). After three weeks causes of enhanced freezing response (traumatic memory) compare with both, shock and sham groups (P<0.001). β-estradiol significantly reduced this response in rats (P<0.001). Conclusion: β-estradiol's administration following PTSD induction by modified single-prolonged stress, significantly decreased the freezing response. Therefore, β-estradiol can prevent the formation of traumatic memory.
Ahouei M, Vaezi Gh, Kalalian Moghaddam H , Alamalhoda F,
Volume 15, Issue 1 (3-2013)
Abstract

Background and Objective: Recent studies have shown that diabetes induced cognitive dysfunction and impairs learning and memory. Palmatine is an isoquinoline alkaloid, and has multiple pharmacological effects, including anti-diabetic and antioxidant activity. This study was conducted, to evaluate the effect of Palmatine on learning and spatial memory impairment in STZ-induced diabetic rats. Materials and Methods: This experimental study was conducted on the male Wistar rats (n=32) with approximate weight of 240±40 grams. The rats were randomly allocated and were divided into 4 groups (n=8): Control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg through intraperitoneal route. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein 1, 3, 5, 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including spatial recognition and objective recognition were performed at the end of study. Data were analyzed by using Prism-5, one way ANOVA and Tukey tests. Results: In spatial recognition test, the number of entrance in new arm of the Ymaze, in the Palmatine-treated groups significantly increased in compare to diabetic group in both sixth and seventh weeks (P<0.05). Number of rearing in new arm significantly increased in sixth and seventh weeks, compare to the diabetic group (P<0.05). The number of recognition novel objects in the Palmatine-treated diabetic group significantly increased in compare to diabetic group (P<0.05). Conclusion: Palmatine hydrochloride administration for 6 weeks improves cognitive dysfunction in streptozotocin-induced diabetic rats.
Afshar M, Moallem Sa , Khayatzadeh J, Taherian N, Hosseini Sm ,
Volume 15, Issue 1 (3-2013)
Abstract

Background and Objective: Carbamazepine during pregnancy can induce various malformations. Recent studies have showed an increase in homocysteine level due to Carbamazepine administration. This study was to evaluate the effect of Carbamazepine on homocysteine serum level in pregnant mice and fetal malformations outcome. Materials and Methods: In this experimental study, 40 BALB/c timed-pregnant mice were allocated into 2 experimental and 2 control groups. The experimental groups were received daily intraperitoneal injections of 30 mg/kg (group I) or 60 mg/kg (group II) of Carbamazepine on gestational days 6 to 15. The control groups were received either - normal saline or Tween 20. Dams underwent Cesarean section on GD 18. External examinations were done and all data concerning malformations, weight and crown-rump of fetuses collected. Blood samples were collected from Dams' hearts prior to performing the Cesarean section. Homocysteine was measured using ELISA method. Data were analyzed using SPSS-18, ANOVA, Chi-Square and Tukey tests. Results: Significant increase in Homocysteine levels of dams’ serum compared to control groups was seen in both experimental groups I and II (10.56±1.31 and 11.11±1.64 µmol/L, respectively, P<0.05). The mean weight and crown-rump of the fetuses in both experimental groups were significantly reduced compared with those of the control groups (P<0.05). Various malformations such as limb defects, vertebral defects, facial deformity and severe malformations were observed in fetuses of both experimental groups. Conclusion: Serum elevation of homocysteine in Carbamazepine exposed pregnant mice may be a risk factor for induction of fetal malformations.
Abdollahi Aa, Mehranfard Sh, Behnampour N, Kordnezhad A,
Volume 15, Issue 3 (10-2013)
Abstract

Background and Objective: Coronary angiography is a routine and gold standard cardiac diagnostic procedure. Patients are restricted to bed rest after the procedure due to potential vascular complications using a femoral approach. Many patients are required to remain on bed rest for up to 24 hours after the procedure. The aim of this study was to assess the effect of changing position and early ambulation on the amount of bleeding, hematoma and urinary retention in patients with coronary angiography. Materials and Methods: In this clinical trial study 140 patients, which referred to coronary angiography center in Dezfoul-Iran, were randomly divided into four 35-individual groups. The patients in the control group were in supine position for 6 hours without movement. Position change was applied to the first interventional group based on a specific protocol, early discharge was applied to the second interventional group and both early discharge and position changes were applied to the third interventional group. The level of bleeding, hematoma and urinary retention were measured at zero, 1, 2, 4, 6 and 24 hours after angiography. The findings were collected using the individual data questionnaire and Kristin Swain’s checklist in order to evaluate the level of bleeding and hematoma. Results: There were no significant differences between the four groups in terms of occurrence of vascular hematoma and bleeding. The incidence of urinary retention was non significantly higher in the control group in compare to others. Conclusion: Changing position following angiography speed up patient discharge from hospital.
Azarhoush R, Aghaii M,
Volume 15, Issue 3 (10-2013)
Abstract

Background and Objective: Rheumatoid arthritis (RA) is a systemic and chronic disease. Anticitrulinated anticyclic antibody (Anti-CCP) and rheumatoid factor (RF) are applied for the diagnosis of rheumatoid arthritis. This study was designed to evaluate the diagnostic value of anticitrulinated cyclic antibody and rheumatoid factor in rheumatoid arthritis patients. Materials and Methods: This laboratory study was done on 238 affected RF patients and 152 RF symptom free subjects in Gorgan, Iran. Anti-CCP and RF were measured by ELISA and Latex agglutination. Results: Out of 238 patients with rheumatoid arthritis Anti-CCP test was positive in 196 patients, and the sensivity was 82%. In control group, Anti-CCP was positive in 5 cases, and the specificity for RA was 96%. RF test was positive in 206 patients and sensitivity for RF in rheumatoid factor was 86%. In control group, RF was positive in 28 cases and specificity was 81%. Positive RF and Anti-CCP (simultaneously) showed sensitivity as 89%. Conclusion: The specificity of CCP is higher than RF and therefore can be substituted as diagnosis of rheumatoid factor.
Masoodpoor N, Arab-Baniasad F , Jafari A,
Volume 15, Issue 3 (10-2013)
Abstract

Background and Objective: Congenital malformations are among important causes of morbidity and mortality in newborns. This study was done to determine the prevalence and pattern of congenital malformations in newborn. Materials and Methods: This descriptive study was done on 6089 newborns in maternity center in Rafsanjan, Iran during 2007-08. The newborns were examined by pediatricians and based on clinical examination the type of obvious of either minor or major malformations were recorded. Results: The 179 cases had at least a major or minor malformations. Over all the prevalence of malformations was 2.93%. The highest prevalence of obvious malformations was seen in the musculo-skeletal (43.5%), followed by genitourinary (22.9%) and cardiovascular systems (15.08%). There was significant relation between congenital malformations, gestational age and medicine used by mothers (P<0.05). Conclusion: The highest prevalence of obvious malformations was seen in the musculo-skeletal system.
Ahouei M, Vaezi Gh, Kalalian Moghaddam H,
Volume 16, Issue 1 (3-2014)
Abstract

Background and Objective: Diabetes induces motor dysfunctions, Palmatine is an isoquinoline alkaloid, with anti-diabetic and antioxidant activities. This study was conducted to evaluate the effect of Palmatine on motor dysfunction in STZ-induced diabetic rats. Materials and Methods: In this experimental study, 32 male wistar rats were randomly allocated into control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg/bw, intraperitoneally. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/bw per day for a period of 6 weeks, one week after induction of diabetes. Blood glucose level was measured 1, 3, 5, 7 weeks after STZ injection. Locomotor activity tests including Y maze, grip-traction and inclined plane tests were performed to determining locomotor activity. Results: In Y maze test, the number of arms entered significantly increased in Palmatine-treated diabetic group compared to diabetic group (P<0.05). Grip traction and inclined plane tests significantly increased in Palmatine-treated diabetic group compared to diabetics animals (P<0.05). Conclusion: Palmatine hydrochloride administration for 6 weeks improves motor dysfunctions in streptozotocin-induced diabetic rats.
Emad Momtaz H, Rahimi M,
Volume 16, Issue 1 (3-2014)
Abstract

Background and Objective: Hematuria is one of the common causes of pediatric nephrology and urology diseases and is reported in 0.5-2% of children. This study was performed to determine the causes of hematuria in infants and children. Methods: This descriptive study was done on 200 infants, children and adolescents in one month to 18 year old ages with chief complaint of hematuria in Hamadan, Iran. Patients were evaluated by urinalysis, urine culture, measurement of calcium, creatinine and uric acid in random urine sample and abdominal sonography. Results: Microscopic and gross hematuria was detected in 79.5% and 20.5% of patients, respectively. Hematuria was idiopathic in 74 (37%) of patients. Urinary tract stones (18%), urinary tract infections (15.5%), hypercalciuria (13%), hyperuricosuria (10%), urinary tract anomalies (5.5%) and glomerulonephritis (1%) were diagnosed as causes of hematuria. Conclusion: In 56% of patients, hematuria was caused by three common etiologies of stone, urinary tract infections and crystalluria.
Nabati M, Eslami S, Piran R,
Volume 16, Issue 1 (3-2014)
Abstract

Penetrating atheromatous ulcer is the condition in which ulceration of an aortic atherosclerotic lesion penetrates the internal elastic lamina into the media. Differentiation of penetrating atheromatous ulcer from other causes of acute aortic syndrome such as intramural haematoma and aortic dissection is difficult. The main symptom is a severe, acute chest pain radiating to the inter-scapular area, similar to classical acute aortic dissection of the thoracic aorta. In present article a case of a 52 years old woman with long- standing retrosternal chest pain and with penetrating atherosclerotic aortic ulcer in descending aorta was reported. Unlike the predominant picture of this disease,associated intramural hematoma was not seen.

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مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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