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Background and Objective: Micro RNAs (or miRNAs) control gene regulation and different biological processes in various tissues and therefore play an important role in various diseases. In some cases, either a single nucleotide polymorphisms (SNPs) in miRNAs or in complementary sequences in their target mRNAs play significant role in human diseases. In this study, the relationship between rs531564 G>C in mir-124-1 with the susceptibility to type 2 diabetes in the Iranian population was examined.

Methods: In this case-control study, 173 individuals affected with type 2 diabetes and 162 healthy individuals were selected. Extracted DNA from peripheral blood was amplified by a pair of relevant primers and then digested by BsmAI restriction enzymes. The obtained electrophoretic patterns were used for genotyping.

Results: The genotype frequencies of GG, GC and CC for rs531564 in the patient group were 0.92, 0.06 and 0.02 respectively, 0.96, 0.04 and 0.00 in the controls. Statistical analysis showed no significant difference between the two groups regarding the genotype frequencies, however the allelic frequencies were significantly different between those groups (P<0.05).

Conclusion: There was no genotype difference between diabetes and healthy individuals, but the allelic C is related with type 2 diabetes among Iranian population.

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Background and Objective: Breast cancer and related treatments induce various physical symptoms. One of suggested method for preventing or reducing physical symptoms is exercise training. This study was done to evaluate the effect of 8 weeks Pilates exercises physical fitness indices in breast cancer patients.
Methods: In this randomized clinical trial study 30 female breast cancer patients were divided into intervention (n=15) and control (n=15) groups by block randomization method. Pilates exercise for 8 weeks, 3 days a week for 60 min in every session was performed in Patients in interventional group but patients in control group did not participate in any regular physical activity. Flexibility, coordination, back and hand strength and muscular strength were determined using Wells, alternate hand wall toss, one leg –stance, back and handgrip dynamometer, sit up tests, respectively.
Results: Pilates exercises significantly increased flexibility, balance, coordination, back and hand strength, muscular endurance and sit up in interventional group in compared to controls (P<0.05).
Conclusion: Pilates exercise improves physical fitness indices in women with breast cancer.