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Background and Objective: Patello femoral pain syndrome is one of the most common orthopeadics complains, which effect athletes, militaries and ordinary people. The symptoms is idiopathic disease, but one of the most important reason for this disease can be the structural problem of lower limb and one of the efficient method of conservative treatment of patients with patello femoral pain syndrome can be using neoprene palumbo and geno direxa stable orthoses, but there is only a few experimental researches supporting the effects of these orthoses. This study was designed to determine the effects of neoprene palumbo and geno direxa stable on pain and daily activity of patients with patello femoral pain syndrome. Materials and Methods: In this clinical trial study 30 male patients (18-40 years old) with patello femoral pain syndrome randomly were divided in 2 groups of 15 patients. Which were placed in Neoprene palumbo and Geno direxa stable orthoses groups respectively. The pain intensity and activity of daily living joint rigidity were assessed before, during and 3 weeks after treatment by visual analogue scale (VAS) and KOOS questionnaire. Following both orthoses application data were analyzed using pair and independent t-test. Results: In both groups the mean of pain intensity decreased and daily physical activity increased after treatment (P<0.05), but there was not significant difference between neoprene palumbo and geno direxa stable methods, on pain and daily physical activities. Conclusion: This study indicated that Neoprene palumbo and geno direxa stable orthoses improved the sign of patello femoral pain syndrome including pain intensity and daily life, activity.

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Background and Objective: Foreign body ingestion is one of the most common problems in otolarygyology in the world. Many kind of foreign body is lodged in esophagus and cause symptoms and complication. Information about patient age and type of foreign bodies and symptoms can help in management and treatment of patients. This study was done to determine the Prevalence of esophageal foreign body and its complications in Gorgan, northern Iran.
Methods: This descriptive retrospective study was done on 145 patients (61 males and 84 females) with foreign body ingestion whom admitted in 5thAzar hospital in Gorgan, northern Iran during 2004-14. Age and type of foreign body and symptoms was recorded for each patient. X-Ray in 41.4% of patients detected foreign body and esophagoscopy in others were used for definitive diagnosis.
Results: Most common chief complaint was dysphagia (42.8%). The most common foreign body was chikenbone (25.5%). Under 15 year’s old patients, coine was the most common. Most common site of lodged was 1/3 upper esophagus (62.63%). In all causes rigid esophaguscopy was used for removal of foreign body. In 56 causes foreign body in esophagus had not any complication.Complications due to foreign bodies were erision (24.82%), ulcer (21.37%), rapture of mucosal layer (6.2%), recurrent refer (4.82%), perforation of esophagus (5 cases, 3.44%) and obsess esophagus(0.68%). Mortality was seen in one patient due to fish bone ingestion.
Conclusion: Dysphagia was the most common chief complaint and coine was the most common foreign body in children. Also, erision and ulcer were the most common complications and upper one third of upper esophagus was the most common site of lodged foreign bodies.

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Arachnoid cysts have primary and secondary types. The prevalence of Arachnoid cysts is about 1% of all tumors in cranial cavity. Based on anatomic position, arachnoid cyst can cause different clinical manifestations including hemiparesis, increase intracranial pressure, macrocephaly and isolated headache and stop body growth. The natural course of the disease is not exactly clear. Some of patients have no symptoms during life and some of them may show some symptoms after a while. This case report is about a 10 years boy who had no sign except generalized headache. Anatomic position of the cyst was in right temporal lobe of the brain on the temporal, parietal and the great wing of sphenoid bones. Arachnoid cyst diagnosed through MRI and CT-Scan. Patient treated with ibuprofen for three days and then patient followed up to treat with surgery method when other clinical symptoms appeare in the patient.

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Background and Objective: In medical sciences, identifying the anticancer properties of plumbagin is of special importance. For this reason, this study investigated the anticancer activity of polymeric nanoparticles loaded by plumbagin against breast cancer cells.
Methods: In this descriptive study, the diblock copolymer mPEG–PCL was synthesized by ring-opening polymerization of caprolactone in the presence of mPEG as the initiator and Sn(oct)2 as the catalyst. The synthesized copolymers were characterized by Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance, gel permeation chromatography, and differential scanning calorimetry. The nanoprecipitation method was used for preparing nanoparticles loaded with plumbagin. The characteristics of these nanoparticles were investigated by various techniques including dynamic light scattering. The cytotoxicity of plumbagin, copolymer, and the nanoparticles loaded with plumbagin on MCF7 and HFF2 cells was evaluated by MTT assay.
Results: The average diameter of the nanoparticles was less than 115 nm. The loading capacity and encapsulation efficiencies were 15.4±0.13% and 79.1±0.65%, respectively. Drug release was slow, controlled, and almost dependent on pH. The results of the MTT assay showed strong and dose-dependent inhibition of cell growth by the plumbagin-loaded micelles compared with plumbagin alone in a way that the half maximal inhibitory concentration of this nanoparticle against MCF7 cells after 48 and 72 hours was 10.78 and 24.03 μM, respectively.
Conclusion: The mPEG-PCL nanoparticles can be an efficient carrier for plumbagin, and plumbagin can be an effective drug on breast cancer cells, without toxicity on healthy cells.