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Background and Objective: Reduction of serum glucose and lipids in diabetic patients due to medicinal plants is clinically very important. Therefore, the effect of Allium schoenoprasum feeding on blood glucose and lipids was investigated in male streptozotocin-diabetic Rats. Materials and Methods: In this experimental study, male Wistar Rats (n=32) were divided into 4 groups, i.e. control, Allium schoenoprasum -treated control, diabetic, and Allium schoenoprasum -treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food at a weight ratio of 6.25% one week after the study for 6 weeks. For induction of diabetes, streptozotocin was administered at a dose of 60 mg/kg (i.p.). Serum glucose and lipids levels were determined before the study and at 3rd and 6th weeks after the study. Results: Serum glucose was significantly lower in Allium schoenoprasum -treated diabetic Rats at 3rd and 6th weeks as compared to untreated diabetics (p<0.05). In addition, serum total cholesterol did not show a significant change at 6th week in Allium schoenoprasum -treated diabetic Rats as compared to untreated diabetics. There was also a significant lower level of triglyceride in Allium schoenoprasum -treated diabetic Rats (p<0.05) and Allium schoenoprasum treatment caused significant improvement in HDL- and LDL- cholesterol levels in treated diabetic group as compared to untreated diabetic group (p<0.05). Conclusion: This study showed that oral administration of Allium schoenoprasum to streptozotocin-diabetic Rats at a food weight ratio of 6.25% has a significant hypoglycemic effect, reduces serum triglyceride and LDL-cholesterol level and increases serum HDL-cholesterol.

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Background and Objective: Chronic diabetes mellitus is accompanied with enhanced oxidative stress and reduce the activity of antioxidant defense system. Due to significant role of enhanced oxidative stress in development of renal damage in diabetices, this study was conducted to evaluate the effect of chronic administration of Silymarin on oxidative stress markers in renal tissue of diabetic rats. Materials and Methods: In this experimental study, 40 male Wistar rats were divided into 5 groups: control, silymarin-treated control (100 mg/kg bw), diabetic, and silymarin -treated diabetic groups (50 and 100 mg/kg bw). Silymarin was administered (daily and intraperitonealy) ten days after Streptozotocin injection for 4 weeks. Tissue level of malondialdehyde and nitrite and nitrate and activity of superoxide dismutase in kidney tissue were measured. Data were analyzed using ANOVA and Tukey tests. Results: A significant increase in tissue level of malondialdehyde, nitrite and nitrate in diabetic rats were observed (P<0.05). Silymarin treatment (100 mg/kg/bw) significantly reduced the tissue level of Malondialdehyde, nitrate and nitrate (P<0.05). Non-significant recduction of activity of superoxide dismutase was oberved in diabetic rats and Silymarin treatment (50 and 100 mg/kg bw) did not significantly altered enzyme activity. Conclusion: Four weeks treatment of Silymarin (100 mg/kg bw) reduce oxidative stress indexes in renal tissue of diabetic rats.