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Diabetes commonly is associated with CAD risk factors, in addition sub-optimal metabolic control of diabetes is associated with increased incidence of thyroid function disorders. In this study patients with diabetes type II who were referred to 5th Azar Hospital in Gorgan were assessed to find out the relationship between thyroid dysfunction and NIDDM in such patients in Gorgan. We studied 210 diabetic patients in hospital outpatient department. The blood pressure, height, weight, serum total Cholesterol, Triglycerides, fasting blood sugar, and glycosylated hemoglobin (HbA1c) were determined. The obesity (BMI>30) were seen in 35% of the subjects. Hypertension and hyperlipidemia were seen in 38 and 65 of our patients respectively. The observed disorders included goiter (30%), sub-clinical hypothyroidism (13%), clinical hypothyroidism (4%), and clinical hyperthyroidism (0.5%). The patients were divided into two groups according to HbA1c: Group 1 with HbA1c<8 and group II with HbA1c?8. A significant difference was observed in TSH serum concentration between group I and II (1.5±1.2 vs. 3.7±11.3 mu/l, P<0.05), whereas the concentration of T4 (10±11 vs. 11±8) and T3 (2.4±3.7 vs. 1.9±3.2) were not significantly different between the two groups. The mean concentration of HbA1c in patients with hypothyroidism was significantly higher than those that of non-hypothyroid subjects (11±2.5 vs. 9±2.5, P<0.005). A significant positive correlation was observed between HbA1c concentration and TSH levels (R=0.2, P<0.01). Our results confirm the association between thyroid dysfunction and uncontrolled diabetes mellitus. It has been recommended that the final diagnosis of thyroid function disorder in diabetic patients should be made after optimal metabolic status has been archived.

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Diabetes mellitus is a common metabolic disorder that is associated with long-term complications of various organs, such as cardiovascular system. This study is about evaluation of myocardial function and determination of related cardiovascular factor in type 2 diabetic patients who referred to diabetes clinic of 5th Azar Hospital from 200 patients who referred to the clinic, 48.5% had diastolic and 29.5% had systolic dysfunction. Related factors with both diastolic and systolic dysfunction of diabetic patients are: HbA1c level (Control of diabetes), duration of diabetes and hypertension. This investigation shows that: Incidence and severity of systolic and diastolic dysfunction in type 2 diabetic patients are related to metabolic state and quality of diabetic control. Incidence of hypertension increase in diabetic patients, and hypertension is an important risk factor in diastolic and systolic dysfunction. Diastolic dysfunction is more common than systolic dysfunction in diabetic patients. Intensive control of blood Glucose level lead to decreasing the incidence of coronary artery disease in diabetic patients. We suggest, intensive control of blood Glucose level, treatment of hypertension, regular cardiovascular evaluation in diabetic patients and screening test for early diagnosis of diabetes in high-risk population should be taken under consideration.

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Background and Objective: Stress hyperglycemia (Transient rise of blood sugar during acute physiologic stress) has been reported in adults in conditions such as trauma, burns, stroke, myocardial infraction and patients admitted for any cause in intensive care unit. In pediatric age group stress hyperglycemia occurs in febrile illness and sever gastroenteritis. Prevalence and importance of stress hyperglycemia is not fully appreciated by physicians. This study was designed to find the frequency of stress hyperglycemia in children and infants admitted in Qaem Hospital and comparing it with other studies in Iran and other countries. Physicians’ knowledge about these phenomena prevents unnecessary and sometimes dangerous intervention. Patients with stress hyperglycemia due to acute clinical illness may be at risk of developing diabetes in future and their follow up is important matter. Materials and Methods: This descriptive cross-sectional study was conducted from March 2001 to May 201 on 334 patients admitted in Qaem Hospital who needed blood sampling for diagnostic tests. Known cases of diabetes mellitus and patients who received corticosteroids or beta-agonist agent and dextrose containing intravenous fluids were excluded from study. Blood sugar was determined by glucose oxidas method. On serum samples within 30 minute-1 hour after blood sampling. Hyperglycemia was defined in our study as blood sugar more than 150 mg/dl, fever as 37.5°C auxiliary temperature, and dehydration status defined as criteria of WHO. Results: 334 patients from age 2 days to 14 years had inclusion criteria, of these 59.5% were male and 40.4% were female. 26.3% of patients had variable degrees of dehydration. 23.7% of patients had auxiliary temperature?38.5°C to 40°C. blood sugar were in the range of 37 mg/dl-325 mg/dl and there was stress hyperglycemia in 17 patients (5.1%). Stress hyperglycemia was obviously more observed in patients with higher temperatures, more sever dehydration or clinical deterioration. There was no case of diabetes mellitus throughout 1-year follow up. Conclusion: Stress hyperglycemia is a relatively frequent clinical and laboratory finding in patients admitted in pediatrics and neonatal wards. There is no relation between the stress hyperglycemia and final diagnosis of patients, however the more serious the clinical condition, the higher the temperatures or more sever dehydration rises the likelihood of stress hyperglycemia.

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Background&Objective: Cancer of the esophagus ranks among the 10 most frequent cancers in the world. As esophagus cancer belt is coincide with loess deposits belt of the world, So there is possibility of close relationship between loess deposits and certain endemic diseases such as esophagus Cancer. This study deals with Loess deposits with medical geology aspect toward diagnosis and prognosis. Materials&Methods: In this study sampling from loess deposits from East towards West of Golestan province has been done. Collected samples have been undergone diffraction X-ray (XRD), scanning electron microscopy (SEM) and Energy dispersive X-ray analysis (EDAX) for determination of minerals, Surface morphology of minerals and chemical analysis for further studies respectively. Results: In mineralogical studies dominated minerals are quartz, feldspar and calcite. Clay minerals are illite and chlorite, which are about 9.3%. The amount of quartz is variable from 56.3 to 45.4. The grains sizes are decreasing from northeast to southwest. Chemical analysis of loess deposits contain Si, Al, K and Ca, which are related to presence of quartz, feldspar, calcite, illite and chlorite minerals. Conclusion: According to medical geology evidences, loess deposits of Golestan province could be considered due to the effects of clay minerals on biochemical cycle, chemical composition of loess deposit for its high silica percentage and direct relationship of grain size with ethiology of esophagus cancer incidence. As variation of esophagus cancer incidence in Golestan province in last 30 years indicates that still high percentage of esophagus cancer incidence which is reported in eastern of province is occurred on loess deposits.

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Background and Objective: One of the problems in urban areas is nitrate contamination of ground waters. High nitrate concentration can cause methemoglobinemia, appearing as a risk factor is provided by ground waters. More than 80% of drinking water of Gorgan, Iran. So this investigation was done to determine of nitrate level in ground waters in Gorgan. This study has been carried out for investigation of nitrate rate in drinking water supply networks and not drinking water ground water wells of Gorgan city. Materials and Methods: This discriptive study was done on 43 ground waters and surface water samples which collected in spring and winter, in Gorgan during 2005. K+, Cl-, NO21-, NO31- of samples were analyzed by spectrophotometery method. Results: The chemical analysis of ground waters of drinking water resources of Gorgan city showed significant variation of nitrate between 3.52 to 69.52 mg/l. The rates of nitrate in certain ground waters wells in vicinity of landfills were between 84.48 to 145.2 mg/l which is more than drinking water standards. Nitrate concentration in agricultural lands such as Shast-kula and Garmabdasht aquifers is lower than Ziarate aquifer in vicinity of urban area. Conclusion: Nitrate contamination in aquifers in vicinity of urban area and unsanitary disposal of solid waste substance may result from house sewage effluents and infiltration of landfill leachs to ground water wells.

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Background and Objective: Diabetes mellitus can cause kidney histological changes. This study was done to evaluate the effect of barley grain (Hordeum vulgare L.) consumption during pregnancy in diabetic rats on kidney histological altrations of offsprings. Methods: In this experimental study, 60 adult female albino rats, randomly allocated into four groups including: healthy with regular meals consumption as control, healthy which consumed barley (10 grams per each rat per daily), diabetic with regular meals consumption and diabetic group which consumed barley (10 grams per each rat per daily). Diabetes was induced by intraperitoneal injection of 45 mg/kg/bw of streptozotocin. After confirmation of pregnancy by observing the vaginal plug, on 21th day, the dams were anesthetized and embryos were removed. Crown rump length and weight of embryos were recorded. After kindney tissue processing, sections with 5 micrometer thickness were stained with H&E method. Results: Interstitial tissue and capillary congestion, Bowman's capsule wall thickening, degeneration of epithelial tissue, distal and proximal tubules, incomplete formation of glomerular and inflammation were observed in embryos of diabeticts group. These tissues alterations significantly reduced in the embryos of diabetic group which consumed barley. The crown rump length of embryos significantly reduced in diabetic group in comparision with controls. There was not any diferences in crown rump length of embryos between diabetic consumed barley and diabetic group. The weight of embryos was non - significantly more in diabetic groups than controls. The weight of embryos reduced non - significantly in diabetic plus barley consumption in comparision with controls. Conclusion: The consumption of barley is beneficial in reducing kidney histological alterations in embryos of diabetic rats.

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Background and Objective: Rapid and adequate rehydration is important for many athletes, especially those taking multiple sessions of exercise each day, or those involved in weight category sports. The macronutrient and electrolyte concentration of the fluid ingested following exercise can affect the amount retained within the body can influence hydration status. This study was done to compare the effect of milk consumption on healthy young men rehydration and endurance performance after dehydration due to intermittent exercise in warm environmental condition. Methods: In this quasi-experimental study, the labroratory protocol was carried out by ten young healthy men in three sessions within one week intervals. Participants were on drinking regiment including water, low-fat milk, and powerade. Urine samples were collected pre-exercise, post-exercise, post-drinking and 1, 2 and 3 hours over recovery. Exercise capacity test commenced within 10 min after 3h recovery. This was undertaken in warm environmental condition at a power output corresponding to 70% VO2 max. Exercise continued until voluntary exhaustion. Heart rate and RPE were recorded at 5 min intervals throughout exercise. Results: Pre-exercise urine specific gravity value was not different between the milk and the, powerade and the water groups. Total urine output was significantly reduced in the milk group in compared to powerade and the water consumption (P<0.05). At the end of the study, net fluid balance was significantly positive in milk group compared to powerade and water groups (P<0.05). Time of exhaustion on the exercise capacity test (70% VO2 max) was significantly more in milk in comparision with powerade group (P<0.05). Conclusion: Low-fat milk is more effective at rehydrating compared to water and exercise capacity in intermittent activity of heat in healthy young men.

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Background and Objective: Increasing the cost of energy in obesity preventing and treating and reducing its complications can be achieved by stimulating the factors including Irisin and FGF21 associated with browning of the white adipose tissue. The aim of this study was to determine the effect of 12 weeks of light and heavy interval exercises on the level of irisin and FGF21 in obese and overweight women.
Methods: This clinical traial study was done on 35 overweight and obese women (39.8±3.85 years old and body mass index 27.1±3.37 kg/m²). The subjects were divided randomly into three groups of interval exercises including Heavy (n=12), light (n=12), and control (n=11) groups. The training program included 12 weeks of heavy and light interval exercises for 25 to 60 minutes per session and three sessions per week. Before and after the training period, irisin and FGF21 serum indices were measured for each subject.
Results: Serum level of FGF21 increased only after 12 weeks of heavy interval training (P<0.05). However, there was no change in serum irisin levels after both heavy and light interval exercises. Body fat percentage, waist to hip ratio, and BMI Subjects of light and heavy interval exercises reduced and VO₂max increased significantly compared to control group (P<0.05).
Conclusion: 12 weeks of low and heavy interval training without altering serum levels of irisin have a beneficial effect on increasing VO₂max and improving body composition. Also, heavy interval training has a significant increase in FGF21, Which can be effective in weight loss through the browning of white adipose tissue.
 

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Background and Objective: Avulsion of permanent teeth is a common emergency condition in pediatric dentistry. The prognosis of avulsed teeth depends on the appropriate and efficient approach of unprofessional persons such as the parents and school teachers who are present at the incident site, prior to the professional dental visit. This study was done to evaluate the parental knowledge regarding emergency management of traumatic tooth avulsion in north of Iran.

Methods: This descriptive-analytic study was performed on 264 parents (76.8% mothers and 23.2% fathers) of children aged 6 to 12 years old whom referred to Ayatollah Taleghani Hospital in Gonbad-e-Kavoos a twon in Golestan Provinece, northern Iran during 2015-16. The subjects were interviewed using a questionnaire form with 11 objective questions. The questionnaire included personal information and parental knowledge about traumatic tooth avulsion.

Results: 84.8% of parents had insufficient knowledge. The father`s and mother`s knowledge rate was 13.3% and 16%, respectively. There was no significant association between educational levels, age or gender and knowledge rate.80.8% of subjects did not received education about how to react after traumatic tooth avulsion.

Conclusion: Parental knowledge regarding emergency management of traumatic tooth avulsion is very low. Considering the irreversible consequences of this injury in delayed management, increasing parental knowledge is necessary.

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Background and Objective: Due to the properties of herbal remedies and their lesser side effects than chemical drugs, much attention has now beeing paid to herbal treatments. The aim of this study was done to evaluate the antinociceptive and anti-inflammatory effects of hydroalcoholic extract of aerial parts of Ruscus aculeatus.
Methods: This experimental study was performed on 80 male NMRI mice (6-8 weeks) weighing 23-25 gr. Animals were randomly allocated into 5 groups including: control group (distilled water), positive control group (morphine 10 mg/kg/bw in pain test and dexamethasone 15 mg/kg/bw in inflammatory test) and three groups receiving 75, 150 and 300 mg/kg/bw Hydroalcoholic extract of Ruscus aculeatus L. The pain was evaluated by formalin test and an investigation of inflammation conducted by xylene induced ear-edema.
Results: The hydroalcoholic extract of Ruscus aculeatus L significantly reduced acute pain at 300 mg/kg/bw in compared to control group (P<0.05). Inhibition percent was 60% for acute pain and 85% in morphine group. Also, this plant caused significant reduction of formalin induced chronic pain at 150 and 300 mg/kg/bw doses in compared to the control group (P<0.05). At 150 and 300 mg/kg doses of Ruscus aculeatus L, inhibition of chronic pain was 71%, and 94%, respectively in compared with 97% inhibition in morphine group.
Conclusion: Hydroalcoholic extract of Ruscus aculeatus L at the dose of 300 mg/kg/bw reduces acute and chronic pain and at the dose of 150 mg/kg/bw reduces acute pain in laboratory animals.

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Background and Objective: The use of packaged drinking water is on the rise nowadays in most countries, including Iran. Currently, more than 100 different brands of packaged drinking water are produced and distributed in Iran. This study was done to evaluate the quality of Iranian, foreign packaged drinking waters and municipal drinking water in Golestan Province, north of Iran.
Methods: This descriptive-analytical study was done on 56 packaged drinking waters of different Iranian and foreign brands, eight brands produced in Golestan province and a number of municipal drinking water samples were collected from Gorgan and Gonbad Kavous cities in northern Iran. To assess the quality of packaged drinking water and drinking water, their physicochemical parameters were compared with National Iranian Standards 1053 and WHO. Stiff and Piper diagrams were plotted to determine the type and hydrochemical facies of water samples. Gibbs and Schoeller diagrams were used to determine the water chemistry controlling factors of water samples and their water quality for drinking, respectively.
Results: The concentrations of physicochemical parameters (except bicarbonate) were within the range of national drinking water standards 1053 and WHO. The average nitrate concentration in all packaged drinking and drinking water was within the standard range. The fluoride concentration of all packaged drinking waters and drinking water was within the range of WHO standard. However, only 14 samples of all packaged drinking and drinking water samples are within the range of 1053 National Iranian Water Standard. The total concentration of soluble solids and the total hardness of packaged drinking water were within the range of 1053 NW. There was also a significant difference (P<0.05) between the chemical parameters of magnesium, sodium, chloride and nitrate in packaged drinking water produced in Golestan province with the municipal drinking water samples.
Conclusion: The amount of fluoride in drinking water in this study was less than desirable and required fluorination. The quality of packaged drinking water in Golestan province is better than the municipal drinking water.

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Background and Objective: Anterior cruciate ligament (ACL) injury is one of the most serious knee injuries and it happens frequently during sports activities. Appropriate muscle activity is essential to provide joint stability and prevention of ACL injury. This study was performed to determine the effect of external focus instructions and functional training on basketball knee stabilization muscle activity timing.
Methods: This clinical trial study was performed on 48 healthy male basketball players of the Iranian Provincial League in the age range of 19-25 years. The basketball players were randomly divided into 3 groups of 16 people including control group, functional training group with feedback and group without feedback. The timing of the onset of electrical activity in the quadriceps, hamstrings, and Gluteus medius muscles of individuals before and after eight weeks in the single-leg landing task was examined by electromyography.
Results: There was a significant difference between the groups at the onset of Biceps Femoris, Gluteus Maximus, Gluteus Medius, Vastus Medialis, Vastus Lateralis, Rectus Femoris and Medial Hamstring muscles. There was a significant decrease in muscle activity onset between functional groups with and without feedback in compared to control group (P<0.05). There was no significant difference between the training groups at the beginning of the activity of the mentioned muscles.
Conclusion: Functional basketball training with and without feedback can optimize the activity time of the knee stabilizing muscles, during exercises such as jump-landing, increase the stability of the knee joint and possibly reduce ACL injury in athletes.

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Background and Objective: Differentiation of white adipose tissue into brown through hormonal and non-hormonal factors, causes weight loss and weakens in obese and overweight people. This study was performed to determine the effect of 12 weeks of interval exercise with different intensities on serum levels of fibroblast growth factor 21 and myostatin in obese and overweight males.
Methods: This clinical trial study was done on 47 obese and overweight males (20.5±0.73 years old). Subjects were randomly divided into four groups: control, interval exercise with low intensity, moderate intensity and high intensity. The exercise program consisted of 12weeks of interval exercise with light, medium and heavy intensity respectively with 58-63, 73-78 and 88-93 percent of Reserve heart rate for 25 to 63 minutes and three sessions per week. Serum indices of fibroblast growth factor 21 and myostatin were measured using fasting blood sample 48 hours before and after exercise program using ELISA method.
Results: Performing 12 weeks of interval training with different intensities was not contribute to significant changes in the serum levels of fibroblast growth factor 21 and myostatin. Implementation of interval exercise at moderate and high intensities was associated with reduction of body fat percentage and increasing in maximal oxygen consumption (VO₂max) in overweight and obese men (P<0.05).
Conclusion: Performing 12 weeks of low, medium and high intensity interval training without changing the serum level of fibroblast growth factor 21 and myostatin has a beneficial effect on improving body composition and increasing VO₂max in obese and overweight young males.