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Showing 2 results for Parivar

Esmail Fattahy, Seyed Gholam Ali Jorsaraei, Kazem Parivar, Ali Akbar Moghaddamnia,
Volume 9, Issue 4 (12-2007)
Abstract

Background & Objective: Hinosan is an organophosphate that inhibit acetylcolinesterase activity, which could be resulted in damages of genital organs. This compound has been used extensively in the agriculture, for pest control. Therefore, in the present study we investigated the effect of Hinosan on spermatogenesis in mice.

Materials & Methods: For this experimental study, the male mice were divided into three groups. In the cases group, mice were injected with Hinosan consecutive doses (20mg/kg i.p, five consecutive days per week for one month), sham (normal saline) and control (no injection). Animals were scarified 7 days after the latest Hinosan injection. Therefore, the mice testis sections were prepared and morphologic aspects of testis and spermatogenesis processes were examined. Data were analyzed using of one-way ANOVA. Significance was set at P<0.05.

Results: The Hinosan showed a significant decrease in number of germ cells, spermatocyt, spermatids, Leydig cells, blood vessels and also diameter of seminiferous on testes of the mice decreased, compared with control groups (P<0.05).

Conclusion: This study demenstrated that Hinosan is effective on spermatogenesis and seminiferous tubule structure, also can decrease germinal cells.


Sadat Sm (msc), Zabihollahi R (md), Vahabpour R (msc), Siadat Sd (phd), Javadi F (msc), Rezaei A (md), Parivar K (phd), Aghasadeghi Mr (phd),
Volume 12, Issue 4 (12-2010)
Abstract

Background and Objective: Human immunodeficiency virus (HIV) belongs to the retroviridae family and is the agent of acquired immunodeficiency syndrome (AIDS). Treatment of HIV for the global health has made a special importance for the new antiviral drug discoveries in addition to HIV vaccine developments. Materials and Methods: In this experimental study single cycle replicable (SCR) HIV-1 virions with the capability of one cycle of replication were produced by the co-transfection of three plasmids of pmzNL4-3, psPAX2 and pMD2.G to the HEK cells and their replication capacity of the first generation SCR visions in HEK 293T, MT-2, and mouse spleen cells was examined by p24-capture ELISA, syncytium formation assay. The infectivity of the SCR-produced virions was also analysed on MT-2 cells. Results: Experiments showed the efficient production of SCR virions. Moreover, results indicated the replication potency of SCR virions on the investigated cells and the inactivity of the produced SCR HIV virions. Complete HIV antigens are expressed in their native forms by SCR virions, but this second viral particles lack the replication capacity. Conclusion: SCR HIV virions produced in this study are capable of one cycle of replication and will be inactivated thereafter.These features make SCR virions as a good candidate for HIV vaccine studies. Moreover, considering the one cycle replication, SCR virions do not need the severe biosafety concerns involved in retrovirus studies.

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مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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