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Background and Objective: Aloe vera (Aloe barbadensis M.) as a medicinal herb is practiced in wound healing. This study was carried out to assess the effect of Aloe vera gel (mucilage) on TGF-β gene expression in incisional skin wound in BALB/c mice. Method: In this experimental study, 36 BALB/c male mice with weight range 22±2 gr were allocated equally into negative control (no wound), sham-operated (wound treated with physiological serum) and teratment (wound treated with Aloe vera gel). Two equal full-thickness skin wounds of 10±2mm were made on either side of the vertebral column in the sacral region. The animals in the teratment group were received daily, 2 gram of Aloe vera gel (without any bandage) as a thin layer for a period of 16 days. On 8th and 16th post wounding day, TGF-β gene expression in incisional wounds and Malonyldialdehyde (as end-product of lipid peroxidation) in serum samples was measured using RT-PCR and spectrophotometry methods, respectively. Results: TGF-β gene expression in incisional skin wound increased in Aloe vera gel treated group in compared to negative control and sham-operated groups (P<0.05). Malonyldialdehyde concentration was significantly reduced in Aloe vera treated group in comparision with negative control and sham-operated groups. Conclusion: Aloe vera gel can induce growth factor TGF-β gene expression and reducing the lipid peroxidation content can play an important role in incisional skin wound healing process.